Targeting the ubiquitin-conjugating enzyme E2D4 for cancer drug discovery–a structure-based approach

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of chemical biology

• Publication date

  2017-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12154-016-0164-6PMID 28405240PMCID PMC5374094
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recent progress in ubiquitin and ubiquitin-like protein (Ubl) signaling

  2016cited by this paper
• Comparative Protein Structure Modeling Using MODELLER

  2016cited by this paper
• Structural insights on identification of potential lead compounds targeting WbpP in Vibrio vulnificus through structure-based approaches

  2016cited by this paper
• Suppressor of Cytokine Signalling‐3 as a Drug Target for Type 2 Diabetes Mellitus: A Structure‐Guided Approach

  2016cited by this paper
• The role of myeloid cells in cancer therapies

  2016cited by this paper
• Homology modeling and virtual screening studies of FGF-7 protein—a structure-based approach to design new molecules against tumor angiogenesis

  2016cited by this paper
• The unravelling of the ubiquitin system

  2015cited by this paper
• Identification of Small Molecular Inhibitors for Efflux Protein: DrrA of Mycobacterium tuberculosis

  2015cited by this paper
• Homology modeling and virtual screening of ubiquitin conjugation enzyme E2A for designing a novel selective antagonist against cancer

  2015cited by this paper
• Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box

  2015cited by this paper
• Analysis of the tryptic search space in UniProt databases

  2014cited by this paper
• New insights into ubiquitin E3 ligase mechanism

  2014cited by this paper
• Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances

  2014cited by this paper
• Identification of novel leads applying in silico studies for Mycobacterium multidrug resistant (MMR) protein

  2014cited by this paper
• Computational Methods in Drug Discovery

  2014cited by this paper
• Docking Challenge: Protein Sampling and Molecular Docking Performance

  2013cited by this paper
• Protein modeling: what happened to the "protein structure gap"?

  2013cited by this paper
• Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma

  2013cited by this paper
• Reciprocal crosstalk between dendritic cells and natural killer cells under the effects of PGE2 in immunity and immunopathology

  2013cited by this paper
• E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis

  2013cited by this paper
• Structure‐based identification of catalytic residues

  2011cited by this paper
• Computer-aided drug design platform using PyMOL

  2011cited by this paper
• AADS - An Automated Active Site Identification, Docking, and Scoring Protocol for Protein Targets Based on Physicochemical Descriptors

  2011cited by this paper
• Revisiting the Ramachandran plot from a new angle

  2011cited by this paper
• Selective inhibition of proteins regulating CDK/cyclin complexes: strategy against cancer—a review

  2010cited by this paper
• Influence of side chain conformations on local conformational features of amino acids and implication for force field development.

  2010cited by this paper
• Quality assessment of protein model-structures using evolutionary conservation

  2010influential reference
• Drug-like Bioactive Structures and Conformational Coverage with the LigPrep/ConfGen Suite: Comparison to Programs MOE and Catalyst

  2010cited by this paper
• Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

  2010cited by this paper
• Prediction of Absolute Solvation Free Energies using Molecular Dynamics Free Energy Perturbation and the OPLS Force Field.

  2010cited by this paper
• Solvent accessible surface area approximations for rapid and accurate protein structure prediction

  2009influential reference
• Identifying and Characterizing Binding Sites and Assessing Druggability

  2009influential reference
• Building ubiquitin chains: E2 enzymes at work

  2009cited by this paper
• Homology modeling in drug discovery: current trends and applications.

  2009cited by this paper
• Automated comparative protein structure modeling with SWISS‐MODEL and Swiss‐PdbViewer: A historical perspective

  2009cited by this paper
• The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways

  2009cited by this paper
• The Jpred 3 secondary structure prediction server

  2008cited by this paper
• Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes

  2008cited by this paper
• Diversity of degradation signals in the ubiquitin–proteasome system

  2008cited by this paper
• Benchmarking the reliability of QikProp. Correlation between experimental and predicted values

  2008influential reference
• Virtual screening in drug discovery -- a computational perspective.

  2007cited by this paper
• Comparative Protein Structure Modeling Using MODELLER

  2007cited by this paper
• Predicting protein function from sequence and structure

  2007cited by this paper
• New Method for Fast and Accurate Binding‐site Identification and Analysis

  2007cited by this paper
• BLAST: improvements for better sequence analysis

  2006cited by this paper
• Comparative Protein Structure Modeling Using Modeller

  2006cited by this paper
• Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes.

  2006cited by this paper
• Drug discovery in the ubiquitin–proteasome system

  2006cited by this paper
• CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues

  2006influential reference
• Integrated Modeling Program, Applied Chemical Theory (IMPACT)

  2005cited by this paper
• Predicting protein function from sequence and structural data.

  2005cited by this paper
• Proteolysis: from the lysosome to ubiquitin and the proteasome

  2005cited by this paper
• The ubiquitin-proteasome pathway and its role in cancer.

  2005cited by this paper
• PatchDock and SymmDock: servers for rigid and symmetric docking

  2005cited by this paper
• ChemMine. A Compound Mining Database for Chemical Genomics1

  2005cited by this paper
• Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sites

  2005cited by this paper
• Lead- and drug-like compounds: the rule-of-five revolution.

  2004cited by this paper
• BLAST: at the core of a powerful and diverse set of sequence analysis tools

  2004cited by this paper
• Docking and scoring in virtual screening for drug discovery: methods and applications

  2004cited by this paper
• Comparative Protein Structure Modeling and its Applications to Drug Discovery

  2004cited by this paper
• Utility of homology models in the drug discovery process

  2004cited by this paper
• A 'rule of three' for fragment-based lead discovery?

  2003cited by this paper
• Prediction of protein function from protein sequence and structure

  2003cited by this paper
• ExPASy: the proteomics server for in-depth protein knowledge and analysis

  2003cited by this paper
• How the ubiquitin–proteasome system controls transcription

  2003cited by this paper
• CASTp: Computed Atlas of Surface Topography of proteins

  2003cited by this paper
• Domain Fishing: a first step in protein comparative modelling

  2002cited by this paper
• Analysis of catalytic residues in enzyme active sites.

  2002cited by this paper
• Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.

  2001influential reference
• CHIP Is a U-box-dependent E3 Ubiquitin Ligase

  2001cited by this paper
• Anatomy of protein pockets and cavities: Measurement of binding site geometry and implications for ligand design

  1998cited by this paper
• Knowledge-based potentials for proteins.

  1995cited by this paper
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper
• Recognition of errors in three‐dimensional structures of proteins

  1993influential reference
• PROCHECK: a program to check the stereochemical quality of protein structures

  1993cited by this paper
• Comparative protein modelling by satisfaction of spatial restraints.

  1993cited by this paper
• Exhaustive matching of the entire protein sequence database.

  1992cited by this paper
• Stereochemical quality of protein structure coordinates

  1992cited by this paper
• Assessment of protein models with three-dimensional profiles

  1992influential reference
• A method to identify protein sequences that fold into a known three-dimensional structure.

  1991cited by this paper
• The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin.

  1988cited by this paper
• Bmc Structural Biology Distantly Related Lipocalins Share Two Conserved Clusters of Hydrophobic Residues: Use in Homology Modeling

  year unknowncited by this paper

• UBE2D4 transcriptionally activated by YY1 drives G2/M progression through enhancing MDM2-dependent p53 degradation in glioma.

  2026cites this paper
• IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer.

  2023cites this paper
• Novel Galactosyl Moiety-Conjugated Furylchalcones Synthesized Facilely Display Significant Regulatory Effect on Plant Growth.

  2022cites this paper
• In Silico Methods for Identification of Potential Active Sites of Therapeutic Targets

  2022cites this paper
• The importance of selecting crystal form for triazole fungicide tebuconazole to enhance its botryticidal activity.

  2022cites this paper
• The Molecular Basis of Ubiquitin-Conjugating Enzymes (E2s) as a Potential Target for Cancer Therapy

  2021cites this paper
• Computational Approaches in Preclinical Studies on Drug Discovery and Development

  2020cites this paper
• E2 ubiquitin-conjugating enzymes in cancer: Implications for immunotherapeutic interventions.

  2019cites this paper
• Functional Analysis of Circulating miRNAs in Pancreatic Cancer

  2018cites this paper
• New Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O

  2018influential citation
• Structural Evaluation and Binding Mode Analysis of CCL19 and CCR7 Proteins—Identification of Novel Leads for Rheumatic and Autoimmune Diseases: An Insilico study

  2017cites this paper
• Identification of New Lead Molecules Against UBE2NL Enzyme for Cancer Therapy

  2017cites this paper