New Approaches to Making the Microenvironment of the Female Reproductive Tract Hostile to HIV

No abstract is available for this paper.

• Publication year

  2011

• Venue

  American Journal of Reproductive Immunology

• Publication date

  2011-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1600-0897.2010.00949.xPMID 21223421PMCID PMC3837342
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation

  2010cited by this paper
• REVIEW ARTICLE: Sex Hormone Regulation of Innate Immunity in the Female Reproductive Tract: The Role of Epithelial Cells in Balancing Reproductive Potential with Protection against Sexually Transmitted Pathogens

  2010cited by this paper
• Keratinocyte Growth Factor Stimulates Macrophage Inflammatory Protein 3α and Keratinocyte‐derived Chemokine Secretion by Mouse Uterine Epithelial Cells

  2010cited by this paper
• Differential susceptibility of HIV strains to innate immune factors in human cervical-vaginal secretions

  2010cited by this paper
• Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

  2010cited by this paper
• Trappin‐2/Elafin: a novel innate anti‐human immunodeficiency virus‐1 molecule of the human female reproductive tract

  2010cited by this paper
• Erratum to: EVOTECH®

  2010cited by this paper
• Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli

  2010cited by this paper
• Anti-HIV Activity in Cervical-Vaginal Secretions from HIV-Positive and -Negative Women Correlate with Innate Antimicrobial Levels and IgG Antibodies

  2010cited by this paper
• Epithelial Cell Secretions from the Human Female Reproductive Tract Inhibit Sexually Transmitted Pathogens and Candida albicans but not Lactobacillus

  2010cited by this paper
• Prospective study of correlates of vaginal Lactobacillus colonisation among high-risk HIV-1 seronegative women

  2009cited by this paper
• Interstitial Cajal-like cells of human Fallopian tube express estrogen and progesterone receptors

  2009cited by this paper
• CCL20/MIP3alpha is a novel anti-HIV-1 molecule of the human female reproductive tract.

  2009cited by this paper
• The superior folding of a RANTES analogue expressed in lactobacilli as compared to mammalian cells reveals a promising system to screen new RANTES mutants.

  2009cited by this paper
• Estradiol Regulates Expression of Estrogen Receptor ERα46 in Human Macrophages

  2009cited by this paper
• Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract.

  2009cited by this paper
• Elevated elafin/trappin-2 in the female genital tract is associated with protection against HIV acquisition

  2009cited by this paper
• Regulation of human tissue kallikrein-related peptidase expression by steroid hormones in 32 cell lines

  2008cited by this paper
• Identification of differentially expressed proteins in the cervical mucosa of HIV-1-resistant sex workers.

  2008cited by this paper
• NK Cells Expressing a Progesterone Receptor Are Susceptible to Progesterone-Induced Apoptosis1

  2008cited by this paper
• A potential role for tissue kallikrein-related peptidases in human cervico-vaginal physiology

  2008cited by this paper
• A new strategy to understand how HIV infects women: identification of a window of vulnerability during the menstrual cycle.

  2008cited by this paper
• Novel innate immune functions of the whey acidic protein family.

  2008cited by this paper
• Preclinical evaluation of lime juice as a topical microbicide candidate

  2008cited by this paper
• Estradiol selectively regulates innate immune function by polarized human uterine epithelial cells in culture

  2008cited by this paper
• Biological activities of a novel selective oestrogen receptor modulator derived from raloxifene (Y134)

  2007cited by this paper
• Bacterial flora of the female genital tract: function and immune regulation.

  2007cited by this paper
• Proteomic analysis of human cervico-vaginal fluid.

  2007cited by this paper
• Phase I Trial of a Lactobacillus crispatus Vaginal Suppository for Prevention of Recurrent Urinary Tract Infection in Women

  2007cited by this paper
• Mucosal Innate Immune Factors in the Female Genital Tract Are Associated with Vaginal HIV-1 Shedding Independent of Plasma Viral Load

  2006cited by this paper
• An anti-HIV microbicide engineered in commensal bacteria: secretion of HIV-1 fusion inhibitors by lactobacilli

  2006cited by this paper
• Identification of estrogen receptor beta-positive intraepithelial lymphocytes and their possible roles in normal and tubal pregnancy oviducts.

  2006cited by this paper
• Sensitivity of non-clade B primary HIV-1 isolates to mildly acidic pH.

  2006cited by this paper
• Function of Liver Activation-Regulated Chemokine/CC Chemokine Ligand 20 Is Differently Affected by Cathepsin B and Cathepsin D Processing1

  2006cited by this paper
• N‐terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4‐68 variant

  2006cited by this paper
• Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides

  2005cited by this paper
• Estrogen and progesterone receptor expression in macrophages and regulation of hepatocyte growth factor by ovarian steroids in women with endometriosis.

  2005cited by this paper
• Differential estrogen receptor gene expression in human peripheral blood mononuclear cell populations.

  2005cited by this paper
• Immunohistochemical localization of oestrogen receptors and progesterone receptors in the human ovary throughout the menstrual cycle

  2005cited by this paper
• Bioengineering Lactic Acid Bacteria to Secrete the HIV-1 Virucide Cyanovirin

  2005cited by this paper
• Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin

  2005cited by this paper
• Innate and adaptive immunity in female genital tract: cellular responses and interactions

  2005cited by this paper
• Immunohistochemical analysis of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in normal human endometrium.

  2004cited by this paper
• Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity.

  2004cited by this paper
• The human corpus luteum: which cells have progesterone receptors?

  2004cited by this paper
• HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration

  2003cited by this paper
• High intraepithelial expression of estrogen and progesterone receptors in the transformation zone of the uterine cervix.

  2003cited by this paper
• Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta.

  2003cited by this paper
• Effects of dietary soy and estrous cycle on adrenal cytochrome p450 1B1 expression and DMBA metabolism in adrenal glands and livers in female Sprague-Dawley rats.

  2003cited by this paper
• Steroid receptor expression in uterine natural killer cells.

  2003cited by this paper
• Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins.

  2003cited by this paper
• Inactivation of Human β-Defensins 2 and 3 by Elastolytic Cathepsins1

  2003cited by this paper
• Inhibition of HIV infectivity by a natural human isolate of Lactobacillus jensenii engineered to express functional two-domain CD4

  2003cited by this paper
• Data mining of public SNP databases for the selection of intragenic SNPs

  2002cited by this paper
• Secretory leukocyte protease inhibitor: inhibition of human immunodeficiency virus-1 infection of monocytic THP-1 cells by a newly cloned protein.

  2002cited by this paper
• Expression of estrogen receptor subtypes and neuronal nitric oxide synthase in neutrophils from women and men: regulation by estrogen.

  2002cited by this paper
• The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling*

  2001cited by this paper
• Expression patterns of cathepsins B, H, K, L and S in the human endometrium.

  2001cited by this paper
• Differential SERM activation of the estrogen receptors (ERalpha and ERbeta) at AP-1 sites.

  2001cited by this paper
• Structure determination of human and murine β‐defensins reveals structural conservation in the absence of significant sequence similarity

  2001cited by this paper
• Differential SERM activation of the estrogen receptors (ERα and ERβ) at AP-1 sites

  2001cited by this paper
• Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs.

  2000cited by this paper
• Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells.

  2000cited by this paper
• Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.

  2000cited by this paper
• Immunolocalisation of oestrogen receptor beta in human tissues.

  2000cited by this paper
• Immunocytochemical Localization of Estrogen Receptors α and β in the Human Reproductive Organs

  2000cited by this paper
• A Human Milk Factor Susceptible to Cathepsin D Inhibitors Enhances Human Immunodeficiency Virus Type 1 Infectivity and Allows Virus Entry into a Mammary Epithelial Cell Line

  2000cited by this paper
• Synergistic and additive killing by antimicrobial factors found in human airway surface liquid.

  2000cited by this paper
• Molecular mechanisms of selective estrogen receptor modulator (SERM) action.

  2000cited by this paper
• Cathepsin G, a Neutrophil-Derived Serine Protease, Increases Susceptibility of Macrophages to Acute Human Immunodeficiency Virus Type 1 Infection

  2000cited by this paper
• Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs.

  2000cited by this paper
• Oestrogen receptor alpha and beta mRNA expression in human endometrium throughout the menstrual cycle.

  1999cited by this paper
• Secretory Leukocyte Protease Inhibitor (SLPI): Oxidation of SLPI Does Not Explain Its Variable Anti-HIV Activity

  1999cited by this paper
• Oestrogen receptor α and β mRNA expression in human endometrium throughout the menstrual cycle

  1999cited by this paper
• Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense.

  1999cited by this paper
• HIV-1 infectivity and host range modification by cathepsin D present in human vaginal secretions.

  1999cited by this paper
• Mechanism of estrogen action: lessons from the estrogen receptor-alpha knockout mouse.

  1998cited by this paper
• An immunohistochemical study of androgen, oestrogen and progesterone receptors in the vulva and vagina

  1998cited by this paper
• Mechanism of Estrogen Action: Lessons from the Estrogen Receptor-α Knockout Mouse

  1998cited by this paper
• Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium.

  1997cited by this paper
• Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern.

  1997cited by this paper
• Progesterone-induced immunosuppression is not mediated through the progesterone receptor.

  1996cited by this paper
• Human immunodeficiency virus type-1 (HIV-1) replication is unaffected by human secretory leukocyte protease inhibitor.

  1996cited by this paper
• Immunohistochemical characterization of proliferation, oestrogen receptor and progesterone receptor expression in endometriosis: comparison of eutopic and ectopic endometrium with normal cycling endometrium.

  1995cited by this paper
• Comparison between novel steroid‐like and conventional nonsteroidal antioestrogens in inhibiting oestradiol‐ and IGF‐I‐induced proliferation of human breast cancer‐derived cells

  1995cited by this paper
• A potent specific pure antiestrogen with clinical potential.

  1991cited by this paper
• Reactivity of lymphocytes to a progesterone receptor-specific monoclonal antibody.

  1990cited by this paper
• Non-steroidal antioestrogens--receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells.

  1984cited by this paper
• The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society Presence of Estrogen Receptor � in the Human Endometrium through the Cycle: Expression in

  year unknowncited by this paper
• Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Human Estrogen Receptor �-Gene Structure, Chromosomal Localization, and Expression Pattern*

  year unknowncited by this paper
• The FASEB Journal • Research Communication Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin

  year unknowncited by this paper
• Estrogen Receptor (cid:1) Is a Novel Marker Expressed by Follicular Dendritic Cells in Lymph Nodes and Tumor-Associated Lymphoid Infiltrates

  year unknowncited by this paper

• Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα.

  2023cites this paper
• Regulation of Mucosal Immunity in the Genital Tract: Balancing Reproduction and Protective Immunity

  2020cites this paper
• A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection

  2019cites this paper
• Antiviral Activity of Fecal Water Samples from HIV-1 Infected Subjects Treated with a Specific Probiotic Formulation

  2019cites this paper
• Antiviral Activity of Faecal Water Samples from HIV-1 Infected Subjects Treated With a Specific Probiotic Formulation.

  2019cites this paper
• Viral Infections During Pregnancy

  2015cites this paper
• Anatomic and Hormonal Changes in the Female Reproductive Tract Immune Environment during the Life Cycle: Implications for HIV/STI Prevention Research

  2014cites this paper
• A Comparative Proteomic Analysis of the Soluble Immune Factor Environment of Rectal and Oral Mucosa

  2014cites this paper
• The immune system in menopause: pros and cons of hormone therapy.

  2014cites this paper
• Interactions between HIV‐1 and Mucosal Cells in the Female Reproductive Tract

  2014cites this paper
• Secreted Mucosal Antimicrobials in the Female Reproductive Tract that are Important to Consider for HIV Prevention

  2014cites this paper
• Candidate microbicides and their mechanisms of action.

  2014influential citation
• Innate Immunity in the Vagina (Part I): Estradiol Inhibits HBD2 and Elafin Secretion by Human Vaginal Epithelial Cells

  2013cites this paper
• HIV gp120 induced gene expression signatures in vaginal epithelial cells.

  2013cites this paper
• Mucosal Immunity in the Human Reproductive Tract: Balancing Reproductive Potential with Protection against Sexually Transmitted Pathogens

  2013cites this paper
• Protective Biofilms in Obstetrics and Gynecology May Be Therapeutic Targets to Reduce Surgical and Delivery Complications

  2013cites this paper
• WAPing Out Pathogens and Disease in the Mucosa: Roles for SLPI and Trappin-2

  2013cites this paper
• Bioengineered probiotics, a strategic approach to control enteric infections

  2013cites this paper
• CHARACTERIZATION OF ANTIVIRAL PROPERTIES OF TRAPPIN-2 AND ELAFIN AGAINST HIV-1 AND HSV-2 IN THE FEMALE GENITAL MUCOSA

  2012cites this paper
• Endocrine control of mucosal immunity in the female reproductive tract: impact of environmental disruptors.

  2012cites this paper
• Anti-HIV-1 Activity of Elafin Is More Potent than Its Precursor's, Trappin-2, in Genital Epithelial Cells

  2012cites this paper
• Precursor's Trappin-2 in Genital Epithelial Cells 2

  2012cites this paper
• Engineering commensal bacteria for prophylaxis against infection.

  2012cites this paper
• Trappin-2/Elafin Modulate Innate Immune Responses of Human Endometrial Epithelial Cells to PolyI∶C

  2012influential citation
• Genital Tract Viral Load in HIV Type 1-Positive Women Correlates with Specific Cytokine Levels in Cervical-Vaginal Secretions But Is Not a Determinant of Infectious Virus or Anti-HIV Activity

  2012influential citation
• Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers.

  2011cites this paper
• Innate Immunity in the Human Female Reproductive Tract: Endocrine Regulation of Endogenous Antimicrobial Protection Against HIV and Other Sexually Transmitted Infections

  2011cites this paper