The P. aeruginosa heme binding protein PhuS is a heme oxygenase titratable regulator of heme uptake.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  ACS Chemical Biology

• Publication date

  2013-06-06

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/cb400165bPMID 23947366PMCID PMC3748626
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolic Flux of Extracellular Heme Uptake in Pseudomonas aeruginosa Is Driven by the Iron-regulated Heme Oxygenase (HemO)*

  2012cited by this paper
• Induced fit on heme binding to the Pseudomonas aeruginosa cytoplasmic protein (PhuS) drives interaction with heme oxygenase (HemO)

  2012cited by this paper
• Characterization of a Heme-Regulated Non-Coding RNA Encoded by the prrF Locus of Pseudomonas aeruginosa

  2010cited by this paper
• Heme uptake across the outer membrane as revealed by crystal structures of the receptor–hemophore complex

  2009cited by this paper
• The Influence of Iron on Pseudomonas aeruginosa Physiology

  2008cited by this paper
• Expression of the phytochrome operon in Pseudomonas aeruginosa is dependent on the alternative sigma factor RpoS.

  2008cited by this paper
• Identification of two heme-binding sites in the cytoplasmic heme-trafficking protein PhuS from Pseudomonas aeruginosa and their relevance to function.

  2007cited by this paper
• Heme acquisition by hemophores

  2007cited by this paper
• Heme and virulence: how bacterial pathogens regulate, transport and utilize heme.

  2007cited by this paper
• How we learnt about iron acquisition in Pseudomonas aeruginosa: a series of very fortunate events

  2007cited by this paper
• The Cytoplasmic Heme-binding Protein (PhuS) from the Heme Uptake System of Pseudomonas aeruginosa Is an Intracellular Heme-trafficking Protein to the δ-Regioselective Heme Oxygenase*

  2006cited by this paper
• The mechanism of heme transfer from the cytoplasmic heme binding protein PhuS to the delta-regioselective heme oxygenase of Pseudomonas aeruginosa.

  2006cited by this paper
• Shigella dysenteriae ShuS Promotes Utilization of Heme as an Iron Source and Protects against Heme Toxicity

  2005cited by this paper
• Structural basis for novel delta-regioselective heme oxygenation in the opportunistic pathogen Pseudomonas aeruginosa.

  2004cited by this paper
• The Heme Oxygenase(s)-Phytochrome System of Pseudomonas aeruginosa*

  2004cited by this paper
• Bacterial iron sources: from siderophores to hemophores.

  2004cited by this paper
• Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis.

  2004cited by this paper
• Haemophore‐mediated bacterial haem transport: evidence for a common or overlapping site for haem‐free and haem‐loaded haemophore on its specific outer membrane receptor

  2001cited by this paper
• Homologues of Neisserial Heme Oxygenase in Gram-Negative Bacteria: Degradation of Heme by the Product of thepigA Gene of Pseudomonas aeruginosa

  2001cited by this paper
• Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa.

  2000cited by this paper
• Biosynthetic preparation of isotopically labeled heme.

  1995cited by this paper
• Transport of haemin across the cytoplasmic membrane through a haemin‐specific periplasmic binding‐protein‐dependent transport system in Yersinia enterocolitica

  1994cited by this paper
• Aerosolized beclomethasone in chronic bronchitis. Improved pulmonary function and diminished airway inflammation.

  1992cited by this paper
• Porphyrins and metalloporphyrins.

  1975cited by this paper
• Cleavage of the haem-protein link by acid methylethylketone.

  1959cited by this paper

• PhuS conformational dynamics are essential for DNA binding and heme-responsive control of the prrF operon in Pseudomonas aeruginosa.

  2026cites this paper
• Heme Trafficking and the Importance of Handling Nature's Most Versatile Cofactor.

  2025cites this paper
• The Pseudomonas aeruginosa PhuS proximal ligand His-209 triggers a conformational switch in function from DNA binding to heme transfer

  2025influential citation
• Quantitative LC-MS/MS Analysis of Endogenous Pseudomonas aeruginosa Isomeric Metabolites Biliverdin IX Alpha, Beta, and Delta in Cell Culture Supernatant, Cell Pellet, and Lung Tissue.

  2025cites this paper
• Mechanisms of bacterial heme uptake and degradation: Diverse strategies for ring opening.

  2025cites this paper
• Heme in Bacterial Pathogenesis and as an Antimicrobial Target

  2025cites this paper
• Pseudomonas aeruginosa heme metabolites biliverdin IXβ and IXδ are integral to lifestyle adaptations associated with chronic infection

  2024cites this paper
• The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression

  2023cites this paper
• Cold atmospheric pressure plasma-antibiotic synergy in Pseudomonas aeruginosa biofilms is mediated via oxidative stress response

  2023cites this paper
• The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression

  2023cites this paper
• Computer-Aided Drug Design: An Update.

  2023cites this paper
• The role of host heme in bacterial infection

  2022cites this paper
• Iron Homeostasis in Pseudomonas aeruginosa: Targeting Iron Acquisition and Storage as an Antimicrobial Strategy.

  2022cites this paper
• Specific and Global RNA Regulators in Pseudomonas aeruginosa

  2021cites this paper
• Extracellular haem utilization by the opportunistic pathogen Pseudomonas aeruginosa and its role in virulence and pathogenesis.

  2021cites this paper
• The heme-binding protein PhuS transcriptionally regulates the Pseudomonas aeruginosa tandem sRNA prrF1,F2 locus

  2021cites this paper
• A High-Throughput Method for Identifying Novel Genes That Influence Metabolic Pathways Reveals New Iron and Heme Regulation in Pseudomonas aeruginosa

  2021cites this paper
• HutW from Vibrio cholerae Is an Anaerobic Heme-Degrading Enzyme with Unique Functional Properties.

  2021cites this paper
• Repurposing Acitretin as an Antipseudomonal Agent Targeting the Pseudomonas aeruginosa Iron-Regulated Heme Oxygenase.

  2021cites this paper
• Modeling the native ensemble of PhuS using enhanced-sampling MD and HDX-ensemble reweighting.

  2021cites this paper
• Contributions of the heme coordinating ligands of the Pseudomonas aeruginosa outer membrane receptor HasR to extracellular heme sensing and transport

  2020cites this paper
• Metallotherapeutics development in the age of iron-clad bacteria.

  2020cites this paper
• A Dynamic Substrate is Required for MhuD-Catalyzed Degradation of Heme to Mycobilin.

  2020cites this paper
• Immune Modulation by Inhibitors of the HO System

  2020cites this paper
• Heme dependent transcriptional regulation of the Pseudomonas aeruginosa tandem sRNA prrF1,F2 locus by the cytoplasmic heme binding protein PhuS

  2020cites this paper
• Coculturing of Mosquito‐Microbiome Bacteria Promotes Heme Degradation in Elizabethkingia anophelis

  2019cites this paper
• Heme uptake and utilization by hypervirulent Acinetobacter baumannii LAC-4 is dependent on a canonical heme oxygenase (abHemO).

  2019cites this paper
• Rôle des voies d'import du fer impliquant des sidérophores dans l'homéostasie de métaux biologiques autres que le fer chez Pseudomonas aeruginosa

  2018cites this paper
• The Asp99–Arg188 salt bridge of the Pseudomonas aeruginosa HemO is critical in allowing conformational flexibility during catalysis

  2018cites this paper
• From Host Heme To Iron: The Expanding Spectrum of Heme Degrading Enzymes Used by Pathogenic Bacteria

  2018cites this paper
• Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme oxygenase (pa-HemO).

  2018cites this paper
• Structural and Functional Characterization of Iron-Containing Oxygenases from Pseudomonas aeruginosa

  2017cites this paper
• Function Coupling Mechanism of PhuS and HemO in Heme Degradation

  2017cites this paper
• Computer-Aided Drug Design Methods.

  2017cites this paper
• Structural basis for binding and transfer of heme in bacterial heme‐acquisition systems

  2017cites this paper
• Extracellular Heme Uptake and the Challenge of Bacterial Cell Membranes.

  2017cites this paper
• HmuS from Yersinia pseudotuberculosis is a non-canonical heme-degrading enzyme to acquire iron from heme.

  2017cites this paper
• Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species

  2017cites this paper
• An alternative reaction for heme degradation catalyzed by the Escherichia coli O157:H7 ChuS protein: Release of hematinic acid, tripyrrole and Fe(III).

  2016cites this paper
• An overview of the biological metal uptake pathways in Pseudomonas aeruginosa.

  2016cites this paper
• Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa.

  2016cites this paper
• HmuS and HmuQ of Ensifer/Sinorhizobium meliloti degrade heme in vitro and participate in heme metabolism in vivo

  2016cites this paper
• Regulation of Pseudomonas aeruginosa Virulence by Distinct Iron Sources

  2016cites this paper
• Heme Synthesis and Acquisition in Bacterial Pathogens.

  2016cites this paper
• Dual-seq transcriptomics reveals the battle for iron during Pseudomonas aeruginosa acute murine pneumonia

  2016cites this paper
• Metabolite-driven Regulation of Heme Uptake by the Biliverdin IXβ/δ-Selective Heme Oxygenase (HemO) of Pseudomonas aeruginosa*

  2016cites this paper
• Spoils of war: iron at the crux of clinical and ecological fitness of Pseudomonas aeruginosa

  2015cites this paper
• Caractérisation des variants R100 et D191 de la protéine de dégradation de l'hème ChuS

  2015cites this paper
• Differential Contributions of the Outer Membrane Receptors PhuR and HasR to Heme Acquisition in Pseudomonas aeruginosa*

  2015cites this paper
• The prrF-Encoded Small Regulatory RNAs Are Required for Iron Homeostasis and Virulence of Pseudomonas aeruginosa

  2014influential citation
• Adaptation of Iron Homeostasis Pathways by a Pseudomonas aeruginosa Pyoverdine Mutant in the Cystic Fibrosis Lung

  2014influential citation
• Heme uptake in bacterial pathogens.

  2014cites this paper
• Mutant in the Cystic Fibrosis Lung by a Pseudomonas aeruginosa Pyoverdine Adaptation of Iron Homeostasis Pathways

  2014cites this paper
• Heme Utilization by Pathogenic Bacteria: Not All Pathways Lead to Biliverdin

  2014cites this paper
• Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans

  2013cites this paper