Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Virology

• Publication date

  2015-09-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.01887-15PMID 26339056PMCID PMC4645678
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• STATs get their move on.

  2013cited by this paper
• Sendai Virus C Proteins Regulate Viral Genome and Antigenome Synthesis To Dictate the Negative Genome Polarity

  2013cited by this paper
• Development of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein–protein interaction

  2013cited by this paper
• Clustered Basic Amino Acids of the Small Sendai Virus C Protein Y1 Are Critical to Its Ran GTPase-Mediated Nuclear Localization

  2013cited by this paper
• Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation.

  2011cited by this paper
• Conserved Charged Amino Acids within Sendai Virus C Protein Play Multiple Roles in the Evasion of Innate Immune Responses

  2010cited by this paper
• Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations

  2008cited by this paper
• Sendai Virus C Protein Plays a Role in Restricting PKR Activation by Limiting the Generation of Intracellular Double-Stranded RNA

  2008cited by this paper
• Paramyxovirus Sendai virus C proteins are essential for maintenance of negative-sense RNA genome in virus particles.

  2008cited by this paper
• Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain.

  2006influential reference
• Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle.

  2005influential reference
• Structural bases of unphosphorylated STAT1 association and receptor binding.

  2005influential reference
• C and V proteins of Sendai virus target signaling pathways leading to IRF-3 activation for the negative regulation of interferon-beta production.

  2004cited by this paper
• Inhibition of the gamma interferon response by a Sendai virus C protein mutant with no STAT1‐binding ability

  2004cited by this paper
• Paramyxovirus Sendai virus-like particle formation by expression of multiple viral proteins and acceleration of its release by C protein.

  2004cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• The STAT2 Activation Process Is a Crucial Target of Sendai Virus C Protein for the Blockade of Alpha Interferon Signaling

  2003cited by this paper
• The C-terminal half-fragment of the Sendai virus C protein prevents the gamma-activated factor from binding to a gamma-activated sequence site.

  2003cited by this paper
• Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase

  2002cited by this paper
• All four Sendai Virus C proteins bind Stat1, but only the larger forms also induce its mono-ubiquitination and degradation.

  2002cited by this paper
• The PyMOL Molecular Graphics System

  2002cited by this paper
• Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1

  2002cited by this paper
• The Amino-Terminal Half of Sendai Virus C Protein Is Not Responsible for either Counteracting the Antiviral Action of Interferons or Down-Regulating Viral RNA Synthesis

  2002cited by this paper
• STAT proteins: signal tranducers and activators of transcription.

  2001cited by this paper
• Y2, the Smallest of the Sendai Virus C Proteins, Is Fully Capable of both Counteracting the Antiviral Action of Interferons and Inhibiting Viral RNA Synthesis

  2001cited by this paper
• Sendai virus C protein physically associates with Stat1

  2001influential reference
• Paramyxoviridae use distinct virus-specific mechanisms to circumvent the interferon response.

  2000cited by this paper
• Versatility of the Accessory C Proteins of Sendai Virus: Contribution to Virus Assembly as an Additional Role

  2000cited by this paper
• Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon-alpha/beta-mediated responses.

  1999cited by this paper
• Sendai Virus C Proteins Counteract the Interferon-Mediated Induction of an Antiviral State

  1999cited by this paper
• Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon‐α/β‐mediated responses

  1999cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• Sendai virus C proteins are categorically nonessential gene products but silencing their expression severely impairs viral replication and pathogenesis

  1998cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Paramyxoviridae : The virus and their replication

  1996cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Free R value: a novel statistical quantity for assessing the accuracy of crystal structures.

  1992cited by this paper
• Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

  1992cited by this paper
• Efficient selection for high-expression transfectants with a novel eukaryotic vector

  1991cited by this paper
• Efficient selection for high-expression transfectants with a novel eukaryotic vector.

  1991cited by this paper

• Structural analysis reveals how tetrameric tyrosine-phosphorylated STAT1 is targeted by the rabies virus P-protein.

  2025cites this paper
• SARS‐CoV‐2 Genome and S2 Spike Protein: IRF‐Driven Interferon Regulation and Host Cell Responses

  2025cites this paper
• Regulation and reversal of paclitaxel resistance via the STAT1-mediated apoptotic pathway in ovarian cancer

  2025cites this paper
• Mammalian innate antiviral defenses: beyond interferon

  2025influential citation
• Molecular basis of IFN-γ–induced STAT3 phosphorylation stimulated by Sendai virus C protein

  2025cites this paper
• Insect dome receptor directly recognizes viral envelopes to activate JAK/STAT signaling and induce conserved antiviral viperin expression.

  2025cites this paper
• Structure of the measles virus ternary polymerase complex

  2025cites this paper
• A Semiquantitative Protein-Fragment Complementation Assay to Study Protein-Protein Interactions of the Polymerase Complex in Cellula.

  2024cites this paper
• African swine fever virus pA104R protein acts as a suppressor of type I interferon signaling

  2023cites this paper
• Discovery of plant-based phytochemical as effective antivirals that target the non-structural protein C of the Nipah virus through computational methods

  2023cites this paper
• Orthoparamyxovirinae C Proteins Have a Common Origin and a Common Structural Organization

  2023influential citation
• C Proteins: Controllers of Orderly Paramyxovirus Replication and of the Innate Immune Response

  2022influential citation
• MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway

  2022influential citation
• Evasion of Host Antiviral Innate Immunity by Paramyxovirus Accessory Proteins

  2022cites this paper
• Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling

  2022cites this paper
• Porcine Epidemic Diarrhea Virus nsp7 Inhibits Interferon-Induced JAK-STAT Signaling through Sequestering the Interaction between KPNA1 and STAT1

  2022cites this paper
• Type I and Type II Interferon Antagonism Strategies Used by Paramyxoviridae: Previous and New Discoveries, in Comparison

  2022cites this paper
• African Swine Fever Virus pI215L Inhibits Type I Interferon Signaling by Targeting Interferon Regulatory Factor 9 for Autophagic Degradation

  2022cites this paper
• A balance between vector survival and virus transmission is achieved through JAK/STAT signaling inhibition by a plant virus

  2022cites this paper
• The Dual Role of STAT1 in Ovarian Cancer: Insight Into Molecular Mechanisms and Application Potentials

  2021influential citation
• Structural Insight into the Interaction of Sendai Virus C Protein with Alix To Stimulate Viral Budding

  2021influential citation
• A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses

  2021cites this paper
• The Measles Virus V Protein Binding Site to STAT2 Overlaps That of IRF9

  2020cites this paper
• Structural comparison of the C-terminal domain of functionally divergent lyssavirus P proteins.

  2020cites this paper
• C Protein Is Essential for Canine Distemper Virus Virulence and Pathogenicity in Ferrets

  2020cites this paper
• Viperin protein inhibits the replication of caprine parainfluenza virus 3 (CPIV 3) by interaction with viral N protein.

  2020cites this paper
• Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface.

  2019cites this paper
• The Molecular Basis of Viral Inhibition of IRF- and STAT-Dependent Immune Responses

  2019cites this paper
• The C Protein Is Recruited to Measles Virus Ribonucleocapsids by the Phosphoprotein

  2019cites this paper
• Respirovirus C protein inhibits activation of type I interferon receptor‐associated kinases to block JAK‐STAT signaling

  2019cites this paper
• Porcine Reproductive and Respiratory Syndrome Virus nsp11 Antagonizes Type I Interferon Signaling by Targeting IRF9

  2019cites this paper
• A Single Amino Acid Substitution within the Paramyxovirus Sendai Virus Nucleoprotein Is a Critical Determinant for Production of Interferon-Beta-Inducing Copyback-Type Defective Interfering Genomes

  2017cites this paper
• Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein

  2017cites this paper
• Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism

  2017cites this paper
• Structural analysis of the STAT1:STAT2 heterodimer revealed the mechanism of Sendai virus C protein–mediated blockade of type 1 interferon signaling

  2017cites this paper
• Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses.

  2016cites this paper
• Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists

  2016cites this paper