Nematicidal activity of fervenulin isolated from a nematicidal actinomycete, Streptomyces sp. CMU-MH021, on Meloidogyne incognita

An isolate of the actinomycete, Streptomyces sp. CMU-MH021 produced secondary metabolites that inhibited egg hatch and increased juvenile mortality of the root-knot nematode Meloidogyne incognita in vitro. 16S rDNA gene sequencing showed that the isolate sequence was 99% identical to Streptomyces roseoverticillatus. The culture filtrates form different culture media were tested for nematocidal activity. The maximal activity against M. incognita was obtained by using modified basal (MB) medium. The nematicidal assay-directed fractionation of the culture broth delivered fervenulin (1) and isocoumarin (2). Fervenulin, a low molecular weight compound, shows a broad range of biological activities. However, nematicidal activity of fervenulin was not previously reported. The nematicidal activity of fervenulin (1) was assessed using the broth microdilution technique. The lowest minimum inhibitory concentrations (MICs) of the compound against egg hatch of M. incognita was 30 μg/ml and juvenile mortality of M. incognita increasing was observed at 120 μg/ml. Moreover, at the concentration of 250 μg/ml fervenulin (1) showed killing effect on second-stage nematode juveniles of M. incognita up to 100% after incubation for 96 h. Isocoumarin (2), another bioactive compound produced by Streptomyces sp. CMU-MH021, showed weak nematicidal activity with M. incognita.

• Publication year

  2010

• Venue

  World Journal of Microbiology & Biotechnology

• Publication date

  2010-10-22

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1007/s11274-010-0588-zPMID 21841897PMCID 3128717
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stemphol Galactoside, a New Stemphol Derivative Isolated from the Tropical Endophytic Fungus Gaeumannomyces amomi

  2010cited by this paper
• Actinomycetes and fungi isolated from plant-parasitic nematode infested soils: screening of the effective biocontrol potential, indole-3-acetic acid and siderophore production

  2010influential reference
• Endophytic actinomycetes isolated from Aquilaria crassna Pierre ex Lec and screening of plant growth promoters production

  2010cited by this paper
• Actinomycetes isolated from medicinal plant rhizosphere soils: diversity and screening of antifungal compounds, indole-3-acetic acid and siderophore production

  2009cited by this paper
• Effect of liquid culture requirements on antifungal antibiotic production by Streptomyces rimosus MY02.

  2008influential reference
• Root-knot nematodes manipulate plant cell functions during a compatible interaction.

  2008cited by this paper
• Control of blast and sheath blight diseases of rice using antifungal metabolites produced by Streptomyces sp. PM5

  2006cited by this paper
• Sensitivity of Meloidogyne incognita and Rotylenchulus reniformis to Abamectin.

  2006influential reference
• Fungi and actinomycetes associated with Meloidogyne spp. eggs and females in China and their biocontrol potential.

  2006influential reference
• Microbial control of plant-parasitic nematodes: a five-party interaction

  2006cited by this paper
• Purification and structure determination of four bioactive molecules from a newly isolated Streptomyces sp. TN97 strain

  2006cited by this paper
• Morphological and Molecular Characterization of a New Root-Knot Nematode, Meloidogyne thailandica n. sp. (Nematoda: Meloidogynidae), Parasitizing Ginger (Zingiber sp.).

  2005influential reference
• Formulation of a soil biofungicide for control of damping-off of Chinese cabbage (Brassica chinensis) caused by Rhizoctonia solani

  2005cited by this paper
• Purification of active components SN06 in fermentation of Streptomyces rimosus MY02

  2004cited by this paper
• Soaking faba bean seed in some bio-agents as prophylactic treatment for controlling Meloidogyne incognita root-knot nematode infection

  2004influential reference
• Biocontrol of Nematode-Borne Diseases in Vegetable Crops

  2004cited by this paper
• Reduction of Landscape Pathogens in Florida by Soil Solarization.

  2002cited by this paper
• Isolation of flavipin, a fungus compound antagonistic to plant-parasitic nematodes

  2002cited by this paper
• Suppression of the root-lesion nematode (Pratylenchus penetrans) in alfalfa (Medicago sativa) by Streptomyces spp.

  2001cited by this paper
• Apomictic, polyphagous root-knot nematodes: exceptionally successful and damaging biotrophic root pathogens.

  2001cited by this paper
• Integrated Pest and Disease Management in Greenhouse Crops

  2001cited by this paper
• Preliminary characterization of some Streptomyces species from four Tanzanian soils and their antimicrobial potential against selected plant and animal pathogenic bacteria

  2000cited by this paper
• Parallel Chromatography in Natural Products Chemistry: Isolation of New Secondary Metabolites from Streptomyces sp

  2000cited by this paper
• Integrated Pest and Disease Management in Greenhouse Crops

  1999cited by this paper
• Control of root-knot nematodes by streptomyces: Screening of root-knot nematode-controlling actinomycetes and evaluation of their usefulness in a pot test

  1999cited by this paper
• Studies on antifungal antibiotics from Ellisiodothis inquinans L1588-A8

  1999influential reference
• The Use of Biological Assays to Evaluate Botanicals

  1998cited by this paper
• Introduction and synopsis of advancements in nematology.

  1998cited by this paper
• Biological control of potato scab in the field with antagonistic Streptomyces scabies.

  1995cited by this paper
• Azotobacter chroococcum and Streptomyces atroolivaceus as biocontrol agents of Xanthomonas campestris pv. malvacearum

  1994cited by this paper
• A novelstreptomyces species for controlling plant-parasitic nematodes

  1993cited by this paper
• Cytogenin, a novel antitumor substance.

  1990cited by this paper
• Insecticidal and nematicidal properties of microbial metabolites

  1987cited by this paper
• The chemistry of the blue stain fungi. Part 3. Some metabolites of Ceratocystisminor (Hedgcock) Hunt

  1987cited by this paper
• The chemistry of the blue stain fungi. Part 1. Some metabolites of Ceratocystis species associated with mountain pine beetle infected lodgepole pine

  1986cited by this paper
• Meloidogyne microcephala n. sp. (Meloidogynidae), a Root-knot Nematode from Thailand.

  1984influential reference
• 6-8-dihydroxy-3-hydroxymethyl-isocoumarin, and other phenolic metabolites of Ceratocystis minor

  1977cited by this paper
• Minor prodiginine pigments from actinomadura madurae and actinomadura pelletieri

  1974influential reference
• THE STRUCTURE OF REUMYCIN

  1973cited by this paper
• Letter: The structure of reumycin.

  1973cited by this paper
• Minor prodiginine pigments fromactinomadura maduraeandactinomadura pelletieri

  1973influential reference
• Synthesis of 1-Demethyltoxoflavin (8-Demethylfervenulin)1

  1966cited by this paper
• Synthesis of 1-demethyltoxoflavin (8-demethylfervenulin).

  1966cited by this paper
• Fervenulin, a new crystalline antibiotic. I. Discovery and biological activities.

  1959cited by this paper

• Harnessing soil yeast for moisture stress mitigation and growth promotion during rice germination

  2026cites this paper
• A bibliometric review of triazine hybrids: synthesis, reactions, and applications spanning the last quarter-century (2000–2025)

  2025cites this paper
• A New Frontier in Plant Defense; the Plant Microbiome as a Shield against Plant Feeding Nematodes and Leverage of Plant Health

  2025cites this paper
• Unveiling the nematotoxic effect of Streptomyces spp. against the root-knot nematode, Meloidogyne enterolobii in guava

  2025influential citation
• Convenient Synthesis, Characterization, Evaluation and molecular docking of Some New Fused Pyrazolo[3,4-d]pyrimidine Derivatives and 3-Methyl-8 phenylpyrazolo[3',4':4,5]pyrimido[6,1-c][1,2,4]triazines Against Hela Cancer Cells

  2025cites this paper
• Review of Secondary metabolites from microbes in the management of plant-parasitic nematodes

  2025cites this paper
• Nematicidal activity of Streptomyces aquilusJXGZ01 against the root‐knot nematode Meloidogyne incognita

  2025cites this paper
• Isolation, screening and identification of actinomycetes from coffee rhizosphere as potential biocontrol against Meloidogyne incognita

  2025cites this paper
• Separation and identification of nematicidal active compounds in culture filtrate of Streptomyces aquilus JXGZ01 based on metabolomic analysis

  2025cites this paper
• Endophytic Bacillus spp. Mediated Plant Growth Promotion of Tomato Seedlings and Suppression of Meloidogyne incognita and Fusarium oxysporum Disease Complex

  2024cites this paper
• Rizobacterias para el control de Meloidogyne en Capsicum annum L. en invernadero

  2024cites this paper
• Antibacterial activity of Streptomyces spp. crude extract on multidrug resistant Psedomonas aeruginosa isolated from clinical samples

  2024cites this paper
• Potential Effects of Nematophagous Fungi Against Meloidogyne javanica Infection of Tomato Plants Under in vitro and in vivo Conditions

  2024cites this paper
• Unlocking the potential of Streptomyces species as promising biological control agents against phytonematodes

  2024cites this paper
• Assessment of Actinomyces and Pseudomonas species on Meloidogyne incognita population and growth of carrot plants in disparate soils

  2023cites this paper
• Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes.

  2023cites this paper
• Chemical properties of 3-tert-butyl-2-oxo1,2-dihydropyrrolo[1,2-b][1,2,4]triazin-6-carboxylates

  2023cites this paper
• Biological control of the root-knot nematode (Meloidogyne incognita) on eggplants with various chitinase-producing Streptomyces strains

  2023cites this paper
• Chemical Properties of 3-tert-Butyl-2-oxo-1,2-dihydro­pyrrolo[1,2-b][1,2,4]triazine-6-carboxylates

  2023cites this paper
• Emerging strategy for eco-friendly management of black pepper root-knot nematodes

  2023cites this paper
• Isolation, Identification and Molecular Mechanism Analysis of the Nematicidal Compound Spectinabilin from Newly Isolated Streptomyces sp. DT10

  2023cites this paper
• Suppression of Meloidogyne incognita by co-application of chitin and Streptomyces nigrescens (AMV1033)

  2023cites this paper
• Efficacy evaluation of Streptomyces nigrescens KA-1 against the root-knot nematode Meloidogyne incognita

  2023cites this paper
• The Potential Use of Actinomycetes as Microbial Inoculants and Biopesticides in Agriculture

  2022cites this paper
• Hydrogen cyanide production by soil bacteria: Biological control of pests and promotion of plant growth in sustainable agriculture

  2022cites this paper
• Soil–Plant–Microbe Interactions Determine Soil Biological Fertility by Altering Rhizospheric Nutrient Cycling and Biocrust Formation

  2022cites this paper
• Differential modulation of the bacterial endophytic microbiota of Festuca arundinaceae (tall fescue) cultivars by the plant-growth promoting strain Streptomyces albidoflavus UYFA156

  2022cites this paper
• Changes of rhizosphere microbiome and metabolites in Meloidogyne incognita infested soil

  2022cites this paper
• Synthesis and DFT analysis of non-covalent interactions in crystal structures of 6-R-2-alkoxy-, 2,3-di-, and 2,2,3-tri-tert-butylpyrrolo[1,2-b][1,2,4]triazines

  2022cites this paper
• Soluble macromolecules from two Streptomyces strains with potent nematicidal activity against Meloidogyne incognita

  2022cites this paper
• Antibacterial activity of Streptomyces sp. Y15 against pathogenic bacteria and evaluation of culture media for antibiotic production

  2022cites this paper
• An In Vitro Nematicidal Activity of Actinobacteria: Juvenile Mortality and Egg Hatching Inhibition

  2022cites this paper
• Nematicidal Streptomyces against Meloidogyne incognita by hydrosoluble macromolecules

  2021cites this paper
• Biological control of root knot nematode, Meloidogyne incognita, in vitro, greenhouse and field in cucumber

  2021cites this paper
• Bioactive antifungal metabolites produced by Streptomyces amritsarensis V31 help to control diverse phytopathogenic fungi

  2021cites this paper
• Natural nematicidal active compounds: Recent research progress and outlook

  2021cites this paper
• Plants Specifically Modulate the Microbiome of Root-Lesion Nematodes in the Rhizosphere, Affecting Their Fitness

  2021cites this paper
• Evaluation of Nematicidal Activity of Streptomyces yatensis KRA-28 against Meloidogyne incognita

  2020cites this paper
• Evaluation of nematicidal activity of Streptomyces yatensis KRA-28 against Meloidogyne incognita.

  2020cites this paper
• Evaluation on the efficiency and persistence of Streptomyces jietaisiensis strain A034 in controlling root knot disease and promoting plant growth in the plant-parasitic nematode infested soils

  2020cites this paper
• Suppression of root-knot nematode and plant growth promotion of chili (Capsicum flutescens L.) using co-inoculation of Streptomyces spp.

  2020cites this paper
• Actinomycete diversity associated with cherry tree rhizospheres and their potential as microbial inoculants

  2020cites this paper
• Τhe Nematicidal Potential of Bioactive Streptomyces Strains Isolated from Greek Rhizosphere Soils Tested on Arabidopsis Plants of Varying Susceptibility to Meloidogyne spp.

  2020cites this paper
• Nematicidal Activity of Teleocidin B4 Isolated from Streptomyces sp. against Pine Wood Nematode, Bursaphelenchus xylophilus.

  2020cites this paper
• Distribution and diversity of bacterial endophytes from four Pinus species and their efficacy as biocontrol agents for devastating pine wood nematodes

  2019cites this paper
• Occurrence of endophytic bacteria in Vietnamese Robusta coffee roots and their effects on plant parasitic nematodes

  2019cites this paper
• Plant Growth-Promoting Microbes for Sustainable Agriculture

  2019cites this paper
• Occurrence of endophytic bacteria in Vietnamese Robusta coffee roots and their effects on plant parasitic nematodes

  2019cites this paper
• αβ-Dehydrocurvularin isolated from the fungus Aspergillus welwitschiae effectively inhibited the behaviour and development of the root-knot nematode Meloidogyne graminicola in rice roots

  2019cites this paper
• Seleção de bactérias para controle biológico de Meloidogyne incognita em figueira

  2019cites this paper
• Nematicidal potential of Streptomyces antibioticus strain M7 against Meloidogyne incognita

  2019cites this paper
• Biocontrol Efficacy of Formulated Pseudomonas chlororaphis O6 against Plant Diseases and Root-Knot Nematodes

  2018cites this paper
• Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent

  2018cites this paper
• Potencial de rizobactérias no controle de Meloidogyne incognita em figueira

  2018cites this paper
• Isolation and identification of causative agent of potato common scab and characterization of effective antagonistic bacteria as biological control of disease.

  2018cites this paper
• Harnessing Useful Rhizosphere Microorganisms for Nematode Control

  2017cites this paper
• Field evaluation of Streptomyces rubrogriseus HDZ-9-47 for biocontrol of Meloidogyne incognita on tomato

  2017cites this paper
• A New Frontier for Biological Control against Plant Pathogenic Nematodes and Insect Pests I: By Microbes

  2017cites this paper
• Production of macrolide antibiotics from a cytotoxic soil Streptomyces sp. strain ZDB

  2017cites this paper
• Biocontrol and growth promotive potential of Streptomyces spp. in black pepper ( Piper nigrum L.)

  2017cites this paper
• Production of macrolide antibiotics from a cytotoxic soil Streptomyces sp. strain ZDB

  2017cites this paper
• Plant growth promotion by streptomycetes: ecophysiology, mechanisms and applications

  2016cites this paper
• Evaluation of in vitro and in vivo nematicidal potential of a multifunctional streptomycete, Streptomyces hydrogenans strain DH16 against Meloidogyne incognita.

  2016cites this paper
• Nematicidal Activity of Streptomyces flavogriseus KRA15-528 to Meloidogyne incognita

  2016cites this paper
• Identification of 2-methylbutyric Acid as a Nematicidal Metabolite, and Biocontrol and Biofertilization Potentials of Bacillus pumilus L1

  2016cites this paper
• [ANTINEMATICIDAL ACTIVITY OF METABOLITES PRODUCED BY SOIL STREPTOMYCETE].

  2016cites this paper
• Streptomyces for Sustainability

  2016cites this paper
• Microbial Models: From Environmental to Industrial Sustainability

  2016cites this paper
• Metabolomics-guided analysis of isocoumarin production by Streptomyces species MBT76 and biotransformation of flavonoids and phenylpropanoids

  2016cites this paper
• Biological Control of Meloidogyne incognita by Aspergillus niger F22 Producing Oxalic Acid

  2016cites this paper
• An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy

  2016cites this paper
• Synergists and antagonists in the rhizosphere modulate microbial communities and growth of Quercus robur L.

  2015cites this paper
• Isolation and identification of chemical constituents from the bacterium Bacillus sp. and their nematicidal activities

  2015cites this paper
• Potential of actinomycetes isolated from earthworm castings in controlling root-knot nematode Meloidogyne incognita

  2015influential citation
• Characterization of Streptomyces netropsis Showing a Nematicidal Activity against Meloidogyne incognita

  2015cites this paper
• Influence of Streptomyces fradiae against Root knot nematode Meloidogyne incognita in Tomato

  2015cites this paper
• ANTIOXIDANT, ANTHELMINTIC AND ENZYME INHIBITORY POTENTIAL OF STREPTOMYCES VARIABILIS STRAIN PO-178 ISOLATED FROM WESTERN GHAT SOIL OF AGUMBE, KARNATAKA, INDIA

  2014cites this paper
• Microbial agents against Helicoverpa armigera: Where are we and where do we need to go?

  2014cites this paper
• Ecological, Physiological and Biochemical Adaptation in Helminth: Trends in Evolution of Anthelminthic Chemical Agents

  2014cites this paper
• EVOLUTION IN CHEMOTHERAPY OF HUMAN AND ANIMAL

  2014cites this paper
• Nematicidal activity of chaetoglobosin A poduced by Chaetomium globosum NK102 against Meloidogyne incognita.

  2013cites this paper
• Responses of nematode-community structure in turfgrass soil to microbial filtrates from municipal–solid waste compost

  2013cites this paper
• Biological activities of Streptomyces species SRDP-07 isolated from soil of Thirthahalli, Karnataka, India

  2013cites this paper
• Antiparasitic Secondary Metabolites from Marine Actinobacteria

  2012cites this paper
• Characterization of Streptomyces strain CMU-MH021, a nematicidal actinomycete isolated from plant-parasitic nematode-infested soil in northern Thailand

  2011cites this paper
• Rhizobacteria for the control of Meloidogyne in Capsicum annum L. in the greenhouse

  year unknowncites this paper