Antimicrobial activity of a quinuclidine-based FtsZ inhibitor and its synergistic potential with β-lactam antibiotics

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of antibiotics (Tokyo. 1968)

• Publication date

  2014-10-08

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/ja.2014.140PMID 25293977
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rational Design of Berberine-Based FtsZ Inhibitors with Broad-Spectrum Antibacterial Activity

  2014cited by this paper
• A Trisubstituted Benzimidazole Cell Division Inhibitor with Efficacy against Mycobacterium tuberculosis

  2014cited by this paper
• Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.

  2013cited by this paper
• Identification of a New Class of FtsZ Inhibitors by Structure-Based Design and in Vitro Screening

  2013cited by this paper
• Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to β-Lactam Antibiotics

  2012cited by this paper
• Targeting the assembly of bacterial cell division protein FtsZ with small molecules.

  2012cited by this paper
• Therapeutic potential of FtsZ inhibition: a patent perspective

  2011cited by this paper
• Anti-virulence strategies to combat bacteria-mediated disease

  2010cited by this paper
• Three Decades of β-Lactamase Inhibitors

  2010cited by this paper
• Surface disinfection properties of the combination of an antimicrobial peptide, ranalexin, with an endopeptidase, lysostaphin, against methicillin‐resistant Staphylococcus aureus (MRSA)

  2010cited by this paper
• FtsZ inhibition: a promising approach for antistaphylococcal therapy.

  2010cited by this paper
• Targeting FtsZ for antibacterial therapy: a promising avenue

  2009cited by this paper
• Antibiotics for Emerging Pathogens

  2009cited by this paper
• Desperately Seeking New Antibiotics

  2008cited by this paper
• An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity

  2008cited by this paper
• Cell-division inhibitors: new insights for future antibiotics

  2008cited by this paper
• Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling.

  2005cited by this paper
• Novel Inhibitors of Bacterial Cytokinesis Identified by a Cell-based Antibiotic Screening Assay*

  2005cited by this paper
• Antibiotics in laboratory medicine

  2005cited by this paper
• Structural insights into FtsZ protofilament formation

  2004cited by this paper
• Dispersed mode of Staphylococcus aureus cell wall synthesis in the absence of the division machinery

  2003cited by this paper
• Glutamate-induced Assembly of Bacterial Cell Division Protein FtsZ*

  2003cited by this paper
• Synergy, antagonism, and what the chequerboard puts between them.

  2003cited by this paper
• Themes and variations in prokaryotic cell division.

  2000cited by this paper
• FtsZ, a prokaryotic homolog of tubulin?

  1995cited by this paper
• FtsZ ring structure associated with division in Escherichia coli

  1991cited by this paper

• An Overview of Drugging the Bacterial Cytoskeleton, Rod, and Divisome Systems.

  2025cites this paper
• Identification of a New FtsZ Inhibitor by Virtual Screening, Mechanistic Insights, and Structure–Activity Relationship Analyses

  2025cites this paper
• Multi‐targets of antimicrobial photodynamic therapy mediated by erythrosine against Staphylococcus aureus identified by proteomic approach

  2024cites this paper
• Computational docking of FtsZ: Survey of promising antibiotic compounds

  2024cites this paper
• Antibacterial sensitizers from natural plants: A powerful weapon against methicillin-resistant Staphylococcus aureus

  2023cites this paper
• Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria

  2022cites this paper
• Impact of FtsZ Inhibition on the Localization of the Penicillin Binding Proteins in Methicillin-Resistant Staphylococcus aureus

  2021cites this paper
• The study of 9,10-dihydroacridine derivatives as a new and effective molecular scaffold for antibacterial agent development.

  2021cites this paper
• Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ

  2020cites this paper
• Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review

  2020cites this paper
• The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens.

  2020cites this paper
• β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium.

  2020cites this paper
• Discovery of novel quaternary ammonium compounds based on quinuclidine-3-ol as new potential antimicrobial candidates.

  2019cites this paper
• Recent Progress in the Development of Small-Molecule FtsZ Inhibitors as Chemical Tools for the Development of Novel Antibiotics

  2019cites this paper
• FtsZ as an Antibacterial Target: Status and Guidelines for Progressing This Avenue.

  2019cites this paper
• Design, synthesis and antibacterial evaluation of 2,4-disubstituted-6-thiophenyl-pyrimidines.

  2019cites this paper
• Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.

  2019cites this paper
• Synthesis, biological evaluation and structure-activity relationships of self-assembled and solubilization properties of amphiphilic quaternary ammonium derivatives of quinuclidine

  2018cites this paper
• Covalent conjugation of cationic antimicrobial peptides with a β‐lactam antibiotic core

  2018cites this paper
• Antibacterial activity of 3-methylbenzo[d]thiazol-methylquinolinium derivatives and study of their action mechanism

  2018cites this paper
• A quinoline-based FtsZ inhibitor for the study of antimicrobial activity and synergistic effects with β-lactam antibiotics.

  2018cites this paper
• Antimicrobial Activity and GC-MS Analysis of Bioactive Constituents of Thermophilic Bacteria Isolated from Saudi Hot Springs

  2018cites this paper
• A Thiazole Orange Derivative Targeting the Bacterial Protein FtsZ Shows Potent Antibacterial Activity

  2017cites this paper
• Mutation at G103 of MtbFtsZ Altered their Sensitivity to Coumarins

  2017cites this paper
• Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action.

  2017cites this paper
• Synthesis, biological evaluation and molecular docking studies of novel quinuclidinone derivatives as potential antimicrobial and anticonvulsant agents

  2017cites this paper
• Stereoselective Synthesis of Piperidines by Iridium-Catalyzed Cyclocondensation.

  2017cites this paper
• Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors

  2017cites this paper
• New application of tiplaxtinin as an effective FtsZ-targeting chemotype for an antimicrobial study.

  2017cites this paper
• Quaternary salts derived from 3-substituted quinuclidine as potential antioxidative and antimicrobial agents

  2017cites this paper
• Chemistry of Antibiotics and Related Drugs

  2016cites this paper
• Identifying targets for potentiators in S. aureus using chemical genetic approaches

  2016cites this paper
• Antibiotics That Affect the Membrane and Other Structural Targets

  2016cites this paper
• Identification of agents targeting FtsZ assembly.

  2016cites this paper
• A Bacterial Cell Shape-Determining Inhibitor.

  2016cites this paper
• FtsZ inhibition and redox modulation with one chemical scaffold: Potential use of dihydroquinolines against mycobacteria.

  2016cites this paper
• Endless Resistance. Endless Antibiotics?

  2016cites this paper
• Targeting the Bacterial Division Protein FtsZ.

  2016cites this paper
• Screening for FtsZ Dimerization Inhibitors Using Fluorescence Cross-Correlation Spectroscopy and Surface Resonance Plasmon Analysis

  2015cites this paper