L-Serine Decreases Taurine Concentration in the Extracellular Fluid of Brain Slices

L-Serine is considered a functional amino acid in the central nervous system, and induces sedation and hypnotic effects in some animal models of acute and chronic stress. Accordingly, while L-serine is a candidate anti-stress factor, the central mechanism of L-serine is not clear. The present study clarifies the action of L-serine using acute chick brain slices. We investigated the changes in some extracellular fluid amino acid concentrations in response to L-serine perfusion. Taurine concentration decreased while L-alanine concentration increased following L-serine perfusion. To examine the involvement of the taurine transporter, the effect of L-serine on the taurine concentration in the presence and absence of Na+ was also investigated. Na+ had no effect on taurine concentration induced by L-serine perfusion. These results suggest that L-serine has an ability to promote L-alanine synthesis facilitating the catabolism of taurine. In conclusion, L-serine modifies the metabolism of taurine and L-alanine in the extracellular space in chick brain.

• Publication year

  2011

• Venue

  Neuroscience and Medicine

• Publication date

  2011-09-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4236/NM.2011.23034
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• X/Y

  2020cited by this paper
• The effects of a low protein diet on amino acids and enzymes in the serine synthesis pathway in mice

  2010cited by this paper
• Oral administration of L-serine reduces the locomotor activity of socially isolated rats.

  2010cited by this paper
• stablishing a physiological environment for visualized in vitro brain slice ecordings by increasing oxygen supply and modifying aCSF content

  2009cited by this paper
• L-Serine-O-phosphate in the central nervous system.

  2009cited by this paper
• Adaptational modification of serine and threonine metabolism in the liver to essential amino acid deficiency in rats

  2009cited by this paper
• Effects of taurine on anxiety-like and locomotor behavior of mice.

  2009cited by this paper
• Characterization of dietary protein-dependent amino acid metabolism by linking free amino acids with transcriptional profiles through analysis of correlation.

  2008cited by this paper
• Central l-alanine reduces energy expenditure with a hypnotic effect under an acute stressful condition in neonatal chicks

  2008cited by this paper
• l-Serine induces sedative and hypnotic effects acting at GABA(A) receptors in neonatal chicks.

  2008cited by this paper
• An essential role for de novo biosynthesis of L-serine in CNS development.

  2008cited by this paper
• Glia-derived D-serine controls NMDA receptor activity and synaptic memory.

  2006cited by this paper
• Intracerebroventricular injection of L-serine analogs and derivatives induces sedative and hypnotic effects under an acute stressful condition in neonatal chicks.

  2006cited by this paper
• Prenatal and early postnatal treatment in 3-phosphoglycerate-dehydrogenase deficiency.

  2004cited by this paper
• Sulfoacetate generated by Rhodopseudomonas palustris from taurine

  2004cited by this paper
• Regulation of the Cellular Content of the Organic Osmolyte Taurine in Mammalian Cells

  2004cited by this paper
• Targeted Disruption of the Mouse 3-Phosphoglycerate Dehydrogenase Gene Causes Severe Neurodevelopmental Defects and Results in Embryonic Lethality*

  2004cited by this paper
• Congenital microcephaly and seizures due to 3-phosphoglycerate dehydrogenase deficiency: Outcome of treatment with amino acids

  2002cited by this paper
• Flux of the l-Serine Metabolism in Rat Liver

  1999cited by this paper
• Role of cysteine in the dietary control of the expression of 3-phosphoglycerate dehydrogenase in rat liver.

  1999cited by this paper
• Mechanistic Studies of Phosphoserine Phosphatase, an Enzyme Related to P-type ATPases*

  1999cited by this paper
• A novel metabolic communication between neurons and astrocytes: non-essential amino acid L-serine released from astrocytes is essential for developing hippocampal neurons.

  1998influential reference
• Conversion of taurine into N-chlorotaurine (taurine chloramine) and sulphoacetaldehyde in response to oxidative stress.

  1998cited by this paper
• 3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis.

  1996cited by this paper
• Metabolic control analysis. The effects of high enzyme concentrations.

  1990cited by this paper
• Metabolic control analysis of mammalian serine metabolism.

  1990cited by this paper
• Control analysis of mammalian serine biosynthesis. Feedback inhibition on the final step.

  1988cited by this paper
• Renal metabolism of amino acids in vivo: studies on serine and glycine fluxes.

  1987cited by this paper
• The reactions of the phosphorylated pathway of L-serine biosynthesis: thermodynamic relationships in rat liver in vivo.

  1986cited by this paper
• [20] Taurine-glutamate transaminase

  1985cited by this paper
• The reactions of the phosphorylated pathway of L-serine biosynthesis: thermodynamic relationships in rabbit liver in vivo.

  1985cited by this paper
• Catabolism of taurine in Pseudomonas aeruginosa.

  1979cited by this paper
• Reciprocal induction and repression of serine dehydratase and phosphoglycerate dehydrogenase by proteins and dietary-essential amino acids in rat liver.

  1973cited by this paper
• Formation of taurine and isethionic acid in rat brain.

  1967cited by this paper
• Methods in Enzymology , Vol

  1966cited by this paper

• Effects of dietary serine addition to a high plant protein diet on growth performance, body composition, hepatosomatic histological structure and metabolism of taurine synthesis in juvenile turbot (Scophthalmus maximus L.).

  2025cites this paper
• Effects of dietary cysteamine addition to a plant-based diet on growth performance, body composition, hepatosomatic histological structure and metabolism of taurine synthesis in turbot (Scophthalmus maximus L.)

  2024cites this paper
• Effect of Low- and High-Sulfur-Containing Amino Acid Inclusion in Diets Fed to Primiparous Sows in Late Gestation on Pre-Partum Nitrogen Retention and Offspring Pre- and Post-Weaning Growth Performance

  2024cites this paper
• Application of a capillary electrophoresis–mass spectrometry metabolomics workflow in zebrafish larvae reveals new effects of cortisol

  2023cites this paper
• Dietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice

  2017cites this paper
• Influence of Low Temperature on the Evolution of Amino Acid Pools Adaptive Modifications inPoikilothermal Animals

  2013cites this paper
• Phosphoethanolamine in brain of the euritherm lake fish Perccottus glehni (Eleotridae, Perciformes, Dyb. 1877) as a phenomenon depending on temperature factor

  2013cites this paper