Membrane domain organization of myelinated axons requires βII spectrin

The spectrin-based cytoskeleton functions as a barrier to restrict axonal proteins, such as juxtaparanodal K+ channels, to specific membrane domains.

• Publication year

  2013

• Venue

  Journal of Cell Biology

• Publication date

  2013-11-11

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1083/jcb.201308116PMID 24217619PMCID 3824014
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Three mechanisms assemble central nervous system nodes of Ranvier.

  2013cited by this paper
• An AnkyrinG-Binding Motif Is Necessary and Sufficient for Targeting Nav1.6 Sodium Channels to Axon Initial Segments and Nodes of Ranvier

  2012cited by this paper
• A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.

  2012cited by this paper
• Early onset West syndrome with severe hypomyelination and coloboma‐like optic discs in a girl with SPTAN1 mutation

  2012cited by this paper
• Cell organization, growth, and neural and cardiac development require αII-spectrin

  2011cited by this paper
• Schwann cell spectrins modulate peripheral nerve myelination

  2011cited by this paper
• Nodes of Ranvier act as barriers to restrict invasion of flanking paranodal domains in myelinated axons.

  2011cited by this paper
• Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay.

  2010cited by this paper
• The axon initial segment and the maintenance of neuronal polarity

  2010cited by this paper
• A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier.

  2010cited by this paper
• Role of transverse bands in maintaining paranodal structure and axolemmal domain organization in myelinated nerve fibers: Effect on longevity in dysmyelinated mutant mice

  2010cited by this paper
• Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

  2010cited by this paper
• Oligodendrocyte Myelin Glycoprotein Does Not Influence Node of Ranvier Structure or Assembly

  2010cited by this paper
• Multiple functions of the paranodal junction of myelinated nerve fibers

  2009cited by this paper
• Spatiotemporal ablation of myelinating glia‐specific neurofascin (NfascNF155) in mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axonal domains

  2009cited by this paper
• Glial and neuronal isoforms of Neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system

  2008cited by this paper
• Postsynaptic Density-93 Clusters Kv1 Channels at Axon Initial Segments Independently of Caspr2

  2008cited by this paper
• Ion Channel Clustering at the Axon Initial Segment and Node of Ranvier Evolved Sequentially in Early Chordates

  2008cited by this paper
• Axons break in animals lacking β-spectrin

  2007cited by this paper
• Faculty Opinions recommendation of Axons break in animals lacking beta-spectrin.

  2007cited by this paper
• Spectrins and AnkyrinB Constitute a Specialized Paranodal Cytoskeleton

  2006cited by this paper
• Glial regulation of the axonal membrane at nodes of Ranvier.

  2006cited by this paper
• It's “juxta” potassium channel!

  2004cited by this paper
• Does Paranode Formation and Maintenance Require Partitioning of Neurofascin 155 into Lipid Rafts?

  2004cited by this paper
• Disruption of Transforming Growth Factor-β Signaling in ELF β-Spectrin-Deficient Mice

  2003cited by this paper
• Paranodal Interactions Regulate Expression of Sodium Channel Subtypes and Provide a Diffusion Barrier for the Node of Ranvier

  2003cited by this paper
• A Targeting Motif Involved in Sodium Channel Clustering at the Axonal Initial Segment

  2003cited by this paper
• Polarized domains of myelinated axons.

  2003cited by this paper
• Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1

  2003cited by this paper
• Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons

  2003cited by this paper
• Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice.

  2003cited by this paper
• Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers

  2003cited by this paper
• The local differentiation of myelinated axons at nodes of Ranvier

  2003cited by this paper
• Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues.

  2001cited by this paper
• Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve.

  2001cited by this paper
• Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin.

  2001cited by this paper
• Organizing principles of the axoglial apparatus.

  2001cited by this paper
• Localization of Caspr2 in Myelinated Nerves Depends on Axon–Glia Interactions and the Generation of Barriers along the Axon

  2001cited by this paper
• Axo-Glial Interactions Regulate the Localization of Axonal Paranodal Proteins

  1999cited by this paper
• Dependence of Nodal Sodium Channel Clustering on Paranodal Axoglial Contact in the Developing CNS

  1999cited by this paper
• Dynamic Potassium Channel Distributions during Axonal Development Prevent Aberrant Firing Patterns

  1999cited by this paper

• Human CNTNAP1 Variants Associated With Severe Neurological Deficits: Additional Cases and Literature Review

  2026cites this paper
• Potassium channel clustering: mechanisms shaping axonal excitability

  2025influential citation
• Identification of candidate genes involved in Zika virus-induced reversible paralysis of mice

  2025cites this paper
• Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain

  2025cites this paper
• The neuron-intrinsic membrane skeleton is required for motor neuron integrity throughout lifespan

  2025cites this paper
• The interplay between mitochondrial dysfunction and NLRP3 inflammasome in multiple sclerosis: Therapeutic implications and animal model studies.

  2024cites this paper
• Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG

  2024cites this paper
• Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG

  2024cites this paper
• The Nodes of Ranvier: Mechanisms of Assembly and Maintenance.

  2024cites this paper
• Adult‐onset depletion of sulfatide leads to axonal degeneration with relative myelin sparing

  2023cites this paper
• Super-resolution imaging pinpoints the periodic ultrastructure at the human node of Ranvier and its disruption in patients with polyneuropathy.

  2023cites this paper
• LGI3/2–ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period

  2023cites this paper
• Spectrins: molecular organizers and targets of neurological disorders

  2023cites this paper
• A class-specific effect of dysmyelination on the excitability of hippocampal interneurons

  2023influential citation
• The Node of Ranvier as an Interface for Axo-Glial Interactions: Perturbation of Axo-Glial Interactions in Various Neurological Disorders

  2023cites this paper
• Nodes of Ranvier in health and disease

  2023cites this paper
• Super-resolution imaging pinpoints ultrastructural changes at the node of Ranvier in patients with polyneuropathy

  2022cites this paper
• Ankyrin-dependent Na+ channel clustering prevents neuromuscular synapse fatigue.

  2021cites this paper
• Impact of Neurofascin on Chronic Inflammatory Demyelinating Polyneuropathy via Changing the Node of Ranvier Function: A Review

  2021cites this paper
• β spectrin-dependent and domain specific mechanisms for Na+ channel clustering

  2020cites this paper
• Molecular organization and function of vertebrate septate-like junctions.

  2020cites this paper
• Nodal β spectrins are required to maintain Na+ channel clustering and axon integrity

  2020cites this paper
• Neuroinflammation in the normal appearing white matter of multiple sclerosis brain causes abnormalities at the node of Ranvier

  2020influential citation
• Cargo hold and delivery: Ankyrins, spectrins, and their functional patterning of neurons

  2020cites this paper
• The clustering of voltage-gated sodium channels in various excitable membranes

  2020cites this paper
• Assembly and Function of the Juxtaparanodal Kv1 Complex in Health and Disease

  2020cites this paper
• Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier

  2020cites this paper
• Mechanisms of node of Ranvier assembly

  2020cites this paper
• Gene's co-expression network and experimental validation of molecular markers associated with the drug resistance of gastric cancer.

  2020cites this paper
• Nodes of Ranvier during development and repair in the CNS

  2020cites this paper
• Accumulation of Neurofascin at Nodes of Ranvier Is Regulated by a Paranodal Switch

  2020cites this paper
• Functional Domains in Myelinated Axons.

  2019cites this paper
• Selective Axonal Expression of the Kv1 Channel Complex in Pre-myelinated GABAergic Hippocampal Neurons

  2019cites this paper
• Axonal Spectrins: Nanoscale Organization, Functional Domains and Spectrinopathies

  2019cites this paper
• Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration

  2019cites this paper
• The clustering of voltage‐gated sodium channels in various excitable membranes

  2019cites this paper
• Duplication 2p16 is associated with perisylvian polymicrogyria

  2019cites this paper
• Myelin in the Central Nervous System: Structure, Function, and Pathology.

  2019cites this paper
• Glial βII Spectrin Contributes to Paranode Formation and Maintenance

  2018cites this paper
• Type 2 Diabetes Leads to Axon Initial Segment Shortening in db/db Mice

  2018cites this paper
• The Actin/Spectrin Membrane-Associated Periodic Skeleton in Neurons

  2018cites this paper
• Nf2 Mutation in Schwann Cells Delays Functional Neural Recovery Following Injury.

  2018cites this paper
• The role of βII spectrin in cardiac health and disease.

  2018cites this paper
• Formation and disruption of functional domains in myelinated CNS axons.

  2017cites this paper
• The Axonal Cytoskeleton and the Assembly of Nodes of Ranvier

  2017cites this paper
• Regulation and dysregulation of axon infrastructure by myelinating glia

  2017cites this paper
• Assembly of CNS Nodes of Ranvier in Myelinated Nerves Is Promoted by the Axon Cytoskeleton

  2017cites this paper
• An αII Spectrin-Based Cytoskeleton Protects Large-Diameter Myelinated Axons from Degeneration

  2017cites this paper
• Regulation and dysregulation of axon infrastructure by myelinating glia

  2017cites this paper
• Regulation and dysregulation of axon infrastructure by myelinating glia

  2017cites this paper
• Submembranous cytoskeletons stabilize nodes of Ranvier.

  2016cites this paper
• The axon as a physical structure in health and acute trauma.

  2016cites this paper
• Etude du rôle des oligodendrocytes dans les mécanismes de formation des noeuds de Ranvier

  2016cites this paper
• Assembly of juxtaparanodes in myelinating DRG culture: Differential clustering of the Kv1/Caspr2 complex and scaffolding protein 4.1B

  2016influential citation
• Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals

  2016cites this paper
• Ultrastructural anatomy of nodes of Ranvier in the peripheral nervous system as revealed by STED microscopy

  2016cites this paper
• The Nodes of Ranvier: Molecular Assembly and Maintenance.

  2016cites this paper
• Cytoskeletal control of axon domain assembly and function.

  2016cites this paper
• Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury

  2016influential citation
• The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier

  2016influential citation
• Glial Contributions to Neural Function and Disease*

  2015cites this paper
• Autoimmune antigenic targets at the node of Ranvier in demyelinating disorders

  2015cites this paper
• Mechanisms of sodium channel clustering and its influence on axonal impulse conduction

  2015influential citation
• The ins and outs of polarized axonal domains.

  2015cites this paper
• Dysfunction in the &bgr;II Spectrin–Dependent Cytoskeleton Underlies Human Arrhythmia

  2015cites this paper
• The Polarity Protein Pals1 Regulates Radial Sorting of Axons

  2015cites this paper
• Subcellular patterning: axonal domains with specialized structure and function.

  2015cites this paper
• Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions

  2015cites this paper
• A HIERARCHY OF ANKYRIN/SPECTRIN COMPLEXES CLUSTERS SODIUM CHANNELS AT NODES OF RANVIER

  2014cites this paper
• Axon initial segments: diverse and dynamic neuronal compartments.

  2014cites this paper
• A neuronal function of the tumor suppressor protein merlin

  2014cites this paper
• GLIAL ANKYRINS FACILITATE PARANODAL AXOGLIAL JUNCTION ASSEMBLY

  2014cites this paper
• [New insights on the organization of the nodes of Ranvier].

  2014cites this paper
• A unified cell biological perspective on axon–myelin injury

  2014cites this paper
• Long-Term Maintenance of Na+ Channels at Nodes of Ranvier Depends on Glial Contact Mediated by Gliomedin and NrCAM

  2014influential citation
• Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions

  2014cites this paper
• Caspr and Caspr2 Are Required for Both Radial and Longitudinal Organization of Myelinated Axons

  2014cites this paper
• A unified cell biological perspective on axon–myelin injury

  2014cites this paper
• Axonal spectrins: All-purpose fences

  2013cites this paper