Location of tumor affects local and distant immune cell type and number

J. Hensel,Vinayak Khattar,Reading Ashton,Carnellia M. Lee,G. Siegal,S. Ponnazhagan

Published 2017 in Immunity, Inflammation and Disease

ABSTRACT

Tumors comprise heterogeneous populations of cells, including immune infiltrates that polarize during growth and metastasis. Our preclinical studies on breast cancer (BCa) identified functional differences in myeloid‐derived suppressor cells based on tumor microenvironment (TME), prompting variations in host immune response to tumor growth, and dissemination based on tissue type.

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