Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Bone and Mineral Research

• Publication date

  2013-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jbmr.1846PMID 23239173PMCID PMC3617088
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001cited by this paper
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  2000influential reference
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  2000cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1991cited by this paper
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  1991cited by this paper
• Characterization and evaluation of asymptomatic primary hyperparathyroidism

  1991cited by this paper
• Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee.

  1987cited by this paper
• Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

  1987cited by this paper
• Age-related changes in parathyroid hormone and parathyroid hormone action in normal humans.

  1984cited by this paper
• Four-parameter model of the sigmoidal relationship between parathyroid hormone release and extracellular calcium concentration in normal and abnormal parathyroid tissue.

  1983cited by this paper
• Vitamin D-dependent calcium-binding protein synthesis by chick kidney and duodenal polysomes.

  1980cited by this paper
• Vitamin D

  1928cited by this paper
• Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Tumor-Specific Decreased Expression of Calcium Sensing Receptor Messenger Ribonucleic Acid in Sporadic Primary Hyperparathyroidism*

  year unknowninfluential reference

• The impact of hypophosphatemia on biochemical profile and renal outcomes in primary hyperparathyroidism: a nationwide retrospective study

  2025cites this paper
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  2024cites this paper
• Calcium/phosphate ratio: an additional tool for the clinical management of asymptomatic primary hyperparathyroidism?

  2023cites this paper
• Phosphate: An underrated component of primary hyperparathyroidism.

  2023cites this paper
• Functional calcium-responsive parathyroid glands generated using single-step blastocyst complementation

  2023cites this paper
• Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells

  2022cites this paper
• Serum Phosphate: A Neglected Test In The Clinical Management Of Primary Hyperparathyroidism.

  2021cites this paper
• Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density

  2021cites this paper
• Calcium‐Sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice

  2020cites this paper
• Biology of the extracellular calcium-sensing receptor

  2020cites this paper
• Control of PTH secretion by the TRPC1 ion channel

  2020cites this paper
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  2020cites this paper
• A critical assessment of the potential of pharmacological modulation of aldehyde dehydrogenases to treat the diseases of bone loss.

  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
• Regulation of skeletal mineralisation by PHOSPHO1.

  2017cites this paper
• Coupling between phosphate and calcium homeostasis: a mathematical model.

  2017cites this paper
• Intestinal absorption and renal reabsorption of calcium throughout postnatal development

  2017cites this paper
• Sex Difference in the Clinical Presentation of Primary Hyperparathyroidism: Influence of Menopausal Status

  2017cites this paper
• Gα11 mutation in mice causes hypocalcemia rectifiable by calcilytic therapy

  2017cites this paper
• A model of calcium homeostasis in the rat.

  2016influential citation
• A Review on the Potential Role of Vitamin D and Mineral Metabolism on Chronic Fatigue Illnesses

  2016cites this paper
• Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co‐Factor in PTH Anabolic Actions in Bone

  2016cites this paper
• Fibroblast Growth Factor 23 and Risk of CKD Progression in Children.

  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Role of IGF-I signaling in muscle bone interactions.

  2015cites this paper
• Determining the role of the calcium sensing receptor in vascular smooth muscle cells via targeted gene deletion

  2014cites this paper
• The extracellular calcium-sensing receptor, CaSR, in fetal development.

  2013cites this paper
• Quantitative trait loci for bone mineral density and femoral morphology in an advanced intercross population of mice.

  2013cites this paper