RAB and RHO GTPases regulate intestinal crypt cell homeostasis and enterocyte function

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Small GTPases

• Publication date

  2016-04-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/21541248.2016.1159274PMID 27142493PMCID PMC4905260
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The localisation of the apical Par/Cdc42 polarity module is specifically affected in microvillus inclusion disease

  2016cited by this paper
• Myo5b knockout mice as a model of microvillus inclusion disease

  2015cited by this paper
• An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking

  2015cited by this paper
• A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer

  2015cited by this paper
• Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK.

  2015cited by this paper
• Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3

  2015cited by this paper
• Transport, metabolism, and endosomal trafficking‐dependent regulation of intestinal fructose absorption

  2015cited by this paper
• Keeping Wnt Signalosome in Check by Vesicular Traffic

  2015cited by this paper
• Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche

  2015influential reference
• Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes

  2015cited by this paper
• Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

  2015cited by this paper
• Wnt Secretion from Epithelial Cells and Subepithelial Myofibroblasts Is Not Required in the Mouse Intestinal Stem Cell Niche In Vivo

  2014cited by this paper
• CDC42 inhibition suppresses progression of incipient intestinal tumors.

  2014cited by this paper
• Loss of syntaxin 3 causes variant microvillus inclusion disease.

  2014cited by this paper
• Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.

  2014cited by this paper
• Rab11a is required for apical protein localisation in the intestine

  2014cited by this paper
• Global Ablation of the Mouse Rab11a Gene Impairs Early Embryogenesis and Matrix Metalloproteinase Secretion*

  2014cited by this paper
• TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis

  2014cited by this paper
• Paneth cells: maestros of the small intestinal crypts.

  2013cited by this paper
• Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice.

  2013cited by this paper
• Cdc42 interacts with the exocyst complex to promote phagocytosis

  2013cited by this paper
• Bem3, a Cdc42 GTPase-activating protein, traffics to an intracellular compartment and recruits the secretory Rab GTPase Sec4 to endomembranes

  2013cited by this paper
• Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

  2013cited by this paper
• RAB8B is required for activity and caveolar endocytosis of LRP6.

  2013cited by this paper
• Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.

  2012cited by this paper
• Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)

  2012cited by this paper
• Wntless in Wnt secretion: molecular, cellular and genetic aspects

  2012cited by this paper
• Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

  2011cited by this paper
• Rab GTPase–Myo5B complexes control membrane recycling and epithelial polarization

  2011cited by this paper
• The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

  2011cited by this paper
• Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

  2011cited by this paper
• Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.

  2010cited by this paper
• Navajo microvillous inclusion disease is due to a mutation in MYO5B

  2008cited by this paper
• MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity

  2008cited by this paper
• The Rab8 GTPase regulates apical protein localization in intestinal cells

  2007cited by this paper
• The Yeast Actin Cytoskeleton: from Cellular Function to Biochemical Mechanism

  2006cited by this paper
• Self-Renewal and Cancer of the Gut: Two Sides of a Coin

  2005cited by this paper
• Wnt signalling induces maturation of Paneth cells in intestinal crypts

  2005cited by this paper
• Wnt control of stem cells and differentiation in the intestinal epithelium.

  2005cited by this paper
• Cdc42 Interacts with the Exocyst and Regulates Polarized Secretion*

  2001cited by this paper
• Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud

  2001cited by this paper
• The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis

  1999cited by this paper
• Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane

  1993cited by this paper
• Microvillus inclusion disease: an inherited defect of brush-border assembly and differentiation.

  1989cited by this paper
• Familial enteropathy: a syndrome of protracted diarrhea from birth, failure to thrive, and hypoplastic villus atrophy.

  1978cited by this paper

• Combining supervised machine learning with statistics reveals differential gene expression patterns related to energy metabolism in the jejuna of chickens divergently selected for antibody response to sheep red blood cells

  2023cites this paper
• Rab8 attenuates Wnt signaling and is required for mesenchymal differentiation into adipocytes

  2021cites this paper
• The GTPase Rab8 differentially controls the long- and short-range activity of the Hedgehog morphogen gradient by regulating Hedgehog apico-basal distribution

  2021cites this paper
• Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration

  2020cites this paper
• The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase/Rho Kinases

  2020cites this paper
• The crucial role of non-coding RNAs in the pathophysiology of inflammatory bowel disease.

  2020cites this paper
• Terminal web and vesicle trafficking proteins mediate nematode single-cell tubulogenesis

  2020cites this paper
• Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease

  2019cites this paper
• Recycling endosomes in mature epithelia restrain tumorigenic signaling.

  2019cites this paper
• Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila

  2019cites this paper
• Formation of Giant Lysosome in Neonatal Ileal Enterocytes Requires Endotubin

  2017cites this paper
• Intestinal GPCRs Control Paneth Cell Maturation and Susceptibility to Experimental Colitis

  2016cites this paper