Genetic screens in mammalian cells by enhanced retroviral mutagens

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Oncogene

• Publication date

  2000-12-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1203992PMID 11146547
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Provirus tagging as an instrument to identify oncogenes and to establish synergism between oncogenes

  2005cited by this paper
• Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells

  2000cited by this paper
• Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival.

  2000cited by this paper
• Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation

  1999cited by this paper
• The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival.

  1999cited by this paper
• A signal sequence trap based on a constitutively active cytokine receptor

  1999cited by this paper
• CD30 in normal and neoplastic cells.

  1999influential reference
• Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation.

  1999cited by this paper
• Leukaemia disease genes: large-scale cloning and pathway predictions

  1999cited by this paper
• Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains.

  1999influential reference
• Systematic gain-of-function genetics in Drosophila.

  1998cited by this paper
• ARF1 Mediates Paxillin Recruitment to Focal Adhesions and Potentiates Rho-stimulated Stress Fiber Formation in Intact and Permeabilized Swiss 3T3 Fibroblasts

  1998cited by this paper
• Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

  1998cited by this paper
• Capturing novel mouse genes encoding chromosomal and other nuclear proteins.

  1998cited by this paper
• Signaling through scaffold, anchoring, and adaptor proteins.

  1997cited by this paper
• Worming your way through the genome.

  1997cited by this paper
• Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress‐ and cytokine‐stimulated monocytes and epithelial cells.

  1996influential reference
• Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain.

  1996cited by this paper
• Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells

  1996cited by this paper
• Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade (*)

  1996cited by this paper
• Mitogen-activated protein kinase cascades and regulation of gene expression.

  1996cited by this paper
• Sequence tags of provirus integration sites in DNAs of tumors induced by the murine retrovirus SL3-3

  1996cited by this paper
• A modular misexpression screen in Drosophila detecting tissue-specific phenotypes.

  1996cited by this paper
• Expression cloning of oncogenes by retroviral transfer of cDNA libraries

  1995influential reference
• Capturing genes encoding membrane and secreted proteins important for mouse development.

  1995cited by this paper
• A new strategy of gene trapping in ES cells using 3'RACE

  1995cited by this paper
• Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor.

  1995cited by this paper
• The Ras signal transduction pathway

  1994cited by this paper
• Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements.

  1994cited by this paper
• High-efficiency identification of genes by functional analysis from a retroviral cDNA expression library

  1994cited by this paper
• Production of high-titer helper-free retroviruses by transient transfection.

  1993cited by this paper
• Transcription termination and polyadenylation in retroviruses

  1993cited by this paper
• Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements

  1993cited by this paper
• Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes.

  1993cited by this paper
• Signal transduction pathway initiated by activation of the sevenless tyrosine kinase receptor.

  1992cited by this paper
• Retroviral mutagenesis of cellular oncogenes: a review with insights into the mechanisms of insertional activation.

  1991cited by this paper
• Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

  1991cited by this paper
• raf oncogenes in carcinogenesis.

  1990cited by this paper
• Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line.

  1990cited by this paper
• Erythropoietin receptor: cloning strategy and structural features.

  1990cited by this paper
• Altering the genome by homologous recombination.

  1989cited by this paper
• Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes.

  1989cited by this paper
• Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal.

  1989cited by this paper
• Identification of cellular promoters by using a retrovirus promoter trap

  1989cited by this paper
• Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells.

  1989cited by this paper
• Selection for precise chromosomal targeting of a dominant marker by homologous recombination.

  1989cited by this paper
• Targeting of nonexpressed genes in embryonic stem cells via homologous recombination.

  1989cited by this paper
• Transgenic animals.

  1988cited by this paper
• Role of RAV-0 genes in the permissive replication of subgroup E avian leukosis viruses on line 15Bev1 CEF.

  1988cited by this paper
• Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

  1988cited by this paper
• Oncogenesis by Moloney murine leukemia virus.

  1987cited by this paper
• Retroviruses as tools for mammalian development.

  1986cited by this paper
• Characterization of murine A-raf, a new oncogene related to the v-raf oncogene

  1986influential reference
• Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase.

  1984cited by this paper
• Myristylation of gag-onc fusion proteins in mammalian transforming retroviruses.

  1984cited by this paper
• Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.

  1983cited by this paper
• DNA rearrangement and altered RNA expression of the c-myb oncogene in mouse plasmacytoid lymphosarcomas.

  1983cited by this paper
• Cancer induction by insertional mutagenesis: the role of viral genes in avian leukosis virus induced cancers.

  1983cited by this paper
• Molecular cloning, genomic analysis, and biological properties of rat leukemia virus and the onc sequences of Rasheed rat sarcoma virus

  1982cited by this paper
• Abelson murine leukemia virus: molecular cloning of infectious integrated proviral DNA.

  1981cited by this paper
• Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

  1981cited by this paper
• Cellular transformation by subgenomic feline sarcoma virus DNA

  1981cited by this paper

• CBFA2T2: a novel H3K27 reader regulating metabolism and tumor growth.

  2026cites this paper
• Epigenetically upregulated GEFT-derived invasion and metastasis of rhabdomyosarcoma via epithelial mesenchymal transition promoted by the Rac1/Cdc42-PAK signalling pathway

  2019cites this paper
• CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

  2017cites this paper
• Mechanistic aspects of mammalian cell size control

  2017cites this paper
• Genome-wide identification of histone H2A and histone variant H2A.Z-interacting proteins by bPPI-seq

  2017cites this paper
• Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq

  2016cites this paper
• Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization

  2015cites this paper
• Biological Networks Governing the Acquisition, Maintenance, and Dissolution of Pluripotency: Insights from Functional Genomics Approaches.

  2015cites this paper
• Regulation of Latent Membrane Protein 1 Signaling through Interaction with Cytoskeletal Proteins

  2015cites this paper
• Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location

  2013cites this paper
• Identification of Transmembrane Protein 134 as a Novel LMP1-Binding Protein by Using Bimolecular Fluorescence Complementation and an Enhanced Retroviral Mutagen

  2012cites this paper
• Nucleoside diphosphate kinase Nm23-M1 involves in oligodendroglial versus neuronal cell fate decision in vitro.

  2012cites this paper
• GEFT, A Rho family guanine nucleotide exchange factor, regulates lens differentiation through a Rac1-mediated mechanism.

  2011cites this paper
• Characterization of the latent membrane protein 1 signaling complex of Epstein-Barr virus in the membrane of mammalian cells with bimolecular fluorescence complementation

  2011cites this paper
• Use of Forward Genetics to Discover Novel Regulators of NF- k B of receptor

  2010cites this paper
• The Onconeural Antigen cdr2 Is a Novel APC/C Target that Acts in Mitosis to Regulate C-Myc Target Genes in Mammalian Tumor Cells

  2010cites this paper
• Gene trapping identifies chloride channel 4 as a novel inducer of colon cancer cell migration, invasion and metastases

  2010cites this paper
• Sleeping beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high-grade astrocytomas.

  2010cites this paper
• Mapkapk 3 is a suppressor of anchorage-independent growth

  2010influential citation
• Use of forward genetics to discover novel regulators of NF-kappaB.

  2010cites this paper
• Genetic mapping of anti-apoptosis pathways in myeloid progenitor cells.

  2009cites this paper
• CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex

  2009cites this paper
• Transposon-based mutagenesis identifies short RIP1 as an activator of NFκB

  2008cites this paper
• Transposon-based mutagenesis identifies short RIP1 as an activator of NFkappaB.

  2008cites this paper
• ERM-mediated genetic screens in mammalian cells.

  2008cites this paper
• Tumor Antigen LRRC15 Impedes Adenoviral Infection: Implications for Virus-Based Cancer Therapy

  2008cites this paper
• Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression.

  2007cites this paper
• Coordinating the activation of RhoA by diverse RhoGEFs: SmgGDS and G -alpha -q -responsive Dbl family guanine nucleotide exchange factors

  2007cites this paper
• Gαq Directly Activates p63RhoGEF and Trio via a Conserved Extension of the Dbl Homology-associated Pleckstrin Homology Domain*

  2007cites this paper
• RNA interference in cancer.

  2006cites this paper
• A Proteomic Approach to Identify Phosphorylation-Dependent Targets of BRCT Domains

  2006cites this paper
• The Rho‐family guanine nucleotide exchange factor GEFT enhances retinoic acid‐ and cAMP‐induced neurite outgrowth

  2006cites this paper
• A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners

  2006cites this paper
• Mutagenesis by reversible promoter insertion to study the activation of NF-κB

  2005cites this paper
• Mutagenesis by reversible promoter insertion to study the activation of NF-kappaB.

  2005cites this paper
• The art and design of genetic screens: mammalian culture cells

  2004cites this paper
• GEFT, A Rho Family Guanine Nucleotide Exchange Factor, Regulates Neurite Outgrowth and Dendritic Spine Formation*

  2004cites this paper
• A Rac/Cdc42-specific Exchange Factor, GEFT, Induces Cell Proliferation, Transformation, and Migration*

  2003cites this paper
• Multiple tumor suppressor pathways negatively regulate telomerase.

  2003cites this paper
• FORWARD GENETICS IN MAMMALIAN CELLS

  2003cites this paper
• Inverse Genomics as a powerful tool to identify novel targets for the treatment of neurodegenerative diseases.

  2003cites this paper
• High-Throughput Selection of Retrovirus Producer Cell Lines Leads to Markedly Improved Efficiency of Germ Line-Transmissible Insertions in Zebra Fish

  2002cites this paper
• High-Throughput Selection of Retrovirus Producer Cell Lines Leads to Markedly Improved Efficiency of Germ Line-Transmissible Insertions in Zebra Fish

  2002cites this paper
• FOUNTAIN: A JAVA open-source package to assist large sequencing projects

  2001cites this paper