Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2009-12-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbrc.2009.10.162PMID 19891958
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK‐Ay mice

  2009cited by this paper
• Dehydroabietic acid

  2009cited by this paper
• Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes.

  2008cited by this paper
• Auraptene, a citrus fruit compound, regulates gene expression as a PPARalpha agonist in HepG2 hepatocytes.

  2008cited by this paper
• Auraptene, a citrus fruit compound, regulates gene expression as a PPARα agonist in HepG2 hepatocytes

  2008cited by this paper
• Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation.

  2008cited by this paper
• Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages.

  2007cited by this paper
• PPARγ and human metabolic disease

  2006cited by this paper
• PPAR gamma and human metabolic disease.

  2006cited by this paper
• Reactive oxygen species have a causal role in multiple forms of insulin resistance

  2006cited by this paper
• Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors.

  2005cited by this paper
• Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes.

  2005cited by this paper
• Phytol directly activates peroxisome proliferator-activated receptor α (PPARα) and regulates gene expression involved in lipid metabolism in PPARα-expressing HepG2 hepatocytes

  2005cited by this paper
• DNA damage and aberrant crypt foci as putative biomarkers to evaluate the chemopreventive effect of annatto (Bixa orellana L.) in rat colon carcinogenesis.

  2005cited by this paper
• Antigenotoxic and antimutagenic potential of an annatto pigment (norbixin) against oxidative stress.

  2005cited by this paper
• PPARs and the complex journey to obesity

  2004cited by this paper
• Abietic acid activates peroxisome proliferator‐activated receptor‐γ (PPARγ) in RAW264.7 macrophages and 3T3‐L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism

  2003cited by this paper
• Dietary supplementation with a natural carotenoid mixture decreases oxidative stress

  2003cited by this paper
• The role of the novel adipocyte-derived hormone adiponectin in human disease.

  2003cited by this paper
• Norbixin ingestion did not induce any detectable DNA breakage in liver and kidney but caused a considerable impairment in plasma glucose levels of rats and mice.

  2002cited by this paper
• Overexpression and Ribozyme-mediated Targeting of Transcriptional Coactivators CREB-binding Protein and p300 Revealed Their Indispensable Roles in Adipocyte Differentiation through the Regulation of Peroxisome Proliferator-activated Receptor γ*

  2002cited by this paper
• Dual action of isoprenols from herbal medicines on both PPARγ and PPARα in 3T3‐L1 adipocytes and HepG2 hepatocytes

  2002cited by this paper
• Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes.

  2002influential reference
• A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity.

  2001cited by this paper
• Antioxidant action of bixin against cisplatin-induced chromosome aberrations and lipid peroxidation in rats.

  2001cited by this paper
• PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

  1999cited by this paper
• PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

  1999cited by this paper
• PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

  1999cited by this paper
• PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.

  1999cited by this paper
• PPAR gamma is required for placental, cardiac, and adipose tissue development.

  1999cited by this paper
• PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance.

  1999cited by this paper
• Bixin and norbixin in human plasma: determination and study of the absorption of a single dose of Annatto food color.

  1997cited by this paper

• Potential of siphonaxanthin, a green algal carotenoid, to prevent obesity and related diseases

  2025influential citation
• Anti-Adipogenic and Anti-Steatotic Potential of Edible Pigment Bixin and Annatto Seed Extracts: LC-MS based Bioactive Profiling and in vitro Biochemical Validation

  2025cites this paper
• Artemether Attenuates High Glucose-Induced Inflammation and Fibrogenesis in Renal Tubular Epithelial Cells by Modulating the TGF-β/Smad Pathway Via PPARγ Activation

  2025cites this paper
• Bixin, a New Atheroprotective Carotenoid Candidate, Prevents oxLDL-Induced Cytotoxicity and Mitochondrial Dysfunction in Macrophages: Involvement of the Nrf2 and NF-κB Pathways

  2024cites this paper
• Environmental Obesogens and Their Perturbations in Lipid Metabolism

  2024cites this paper
• Potential use of bixin beyond function as a natural colourant in food and cosmetics

  2024cites this paper
• Anti-Obesity and Anti-Steatotic Effects of Bixin (Apocarotenoid from Bixa orellana L. Seeds): Dose-Dependent Correlations with Bioactivity

  2024cites this paper
• Naturally Occurring Compounds Targeting Peroxisome Proliferator Receptors: Potential Molecular Mechanisms and Future Perspectives for Promoting Human Health

  2024cites this paper
• Therapeutic application of natural compounds for skeletal muscle-associated metabolic disorders: A review on diabetes perspective.

  2023cites this paper
• Curative role of natural PPARγ agonist in non-alcoholic fatty liver disease (NAFLD)

  2023cites this paper
• Natural Products in Non-alcoholic Fatty Liver Disease (NAFLD): Novel lead discovery for drug development.

  2023cites this paper
• The landscape of potential health benefits of carotenoids as natural supportive therapeutics in protecting against Coronavirus infection

  2022cites this paper
• Effects of feeding ractopamine hydrochloride with or without supplemental betaine on live performance, carcass and meat quality traits, and gene expression of finishing pigs.

  2022cites this paper
• Norbixin, a natural dye that improves serum lipid profile in rabbits and prevents LDL oxidation.

  2022cites this paper
• Bixin attenuates mechanical allodynia, anxious and depressive-like behaviors associated with experimental diabetes counteracting oxidative stress and glycated hemoglobin.

  2021cites this paper
• Erucic Acid-Rich Yellow Mustard Oil Improves Insulin Resistance in KK-Ay Mice

  2021cites this paper
• Bixin protects mice against bronchial asthma though modulating PI3K/Akt pathway.

  2021cites this paper
• A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin

  2021cites this paper
• Carotenoids as Antidiabetic Agents

  2021cites this paper
• Carotenoids and carotenoid conversion products in adipose tissue biology and obesity: Pre-clinical and human studies.

  2020cites this paper
• Targeting type II diabetes with plant terpenes: the new and promising antidiabetic therapeutics

  2020cites this paper
• Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-γ/TGF-β1/Smad3 pathway.

  2020cites this paper
• Medicinal plants utilized in Thai Traditional Medicine for diabetes treatment: Ethnobotanical surveys, scientific evidence and phytochemicals.

  2020cites this paper
• Targeting type II diabetes with plant terpenes: the new and promising antidiabetic therapeutics

  2020cites this paper
• Mechanisms of action, chemical characteristics, and model systems of obesogens

  2020cites this paper
• A Pilot Screening of Agro-Food Waste Products as Sources of Nutraceutical Formulations to Improve Simulated Postprandial Glycaemia and Insulinaemia in Healthy Subjects

  2020cites this paper
• Overview of carotenoids and beneficial effects on human health

  2020cites this paper
• A2E induces the transactivation of RARs, PPARs and RXRs and its effects are counteracted by norbixin in retinal pigment epithelium cells in vitro

  2020cites this paper
• Assessment of the hypoglycemic effect of Bixin in alloxan-induced diabetic rats: in vivo and in silico studies

  2020cites this paper
• Antinociceptive and Anti-Inflammatory Effects of Bixin, a Carotenoid Extracted from the Seeds of Bixa orellana

  2019cites this paper
• A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors

  2019cites this paper
• Dietary Carotenoids in Managing Metabolic Syndrome and Role of PPARs in the Process

  2019cites this paper
• Combining In Vitro Data and Physiologically Based Kinetic Modeling Facilitates Reverse Dosimetry to Define In Vivo Dose–Response Curves for Bixin‐ and Crocetin‐Induced Activation of PPARγ in Humans

  2019cites this paper
• Evidence of hypoglycemic, lipid-lowering and hepatoprotective effects of the Bixin and Bixin: β-CD inclusion compound in high-fat-fed obese mice.

  2018cites this paper
• (all‐E)‐ and (5Z)‐Lycopene Display Similar Biological Effects on Adipocytes

  2018cites this paper
• Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin

  2018cites this paper
• Betaine promotes lipid accumulation in adipogenic-differentiated skeletal muscle cells through ERK/PPARγ signalling pathway

  2018cites this paper
• Nutraceuticals and the Skin: Roles in Health and Disease

  2018cites this paper
• Selected Phyto and Marine Bioactive Compounds: Alternatives for the Treatment of Type 2 Diabetes

  2018cites this paper
• Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin

  2017cites this paper
• A New Agonist for Peroxisome Proliferation-activated Receptor γ (PPARγ), Fraglide-1 from Zhenjiang Fragrant Vinegar: Screening and Characterization Based on Cell Culture Experiments.

  2017cites this paper
• Suppressive Effects of Carotenoids on Proliferation and Differentiation of 3T3-L1 Preadipocytes

  2017cites this paper
• Annatto carotenoids attenuate oxidative stress and inflammatory response after high-calorie meal in healthy subjects.

  2017cites this paper
• Carotenoids in the treatment of diabetes mellitus and its complications: A mechanistic review.

  2017cites this paper
• Protective Effects of Carotenoids in Cardiovascular Disease and Diabetes

  2017cites this paper
• PPARα/γ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats

  2017cites this paper
• Inhibitory effect of apocarotenoids on the activity of tyrosinase: Multi-spectroscopic and docking studies.

  2016cites this paper
• Effect of bixin on DNA damage and cell death induced by doxorubicin in HL60 cell line

  2016cites this paper
• Role of PPARγ in the nutritional and pharmacological actions of carotenoids

  2016cites this paper
• Effects of bixin in high-fat diet-fed-induced fatty liver in C57BL/6J mice

  2016cites this paper
• Focus on Mechanisms Linking to Childhood Obesity

  2016cites this paper
• Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo

  2016cites this paper
• Renaissance in phytomedicines: promising implications of NGS technologies

  2016cites this paper
• Effects of Carotenoids on 3T3-L1 Preadipocyte Viability and Differentiation

  2015cites this paper
• Nymphaea nouchali Burm. f. hydroalcoholic seed extract increases glucose consumption in 3T3-L1 adipocytes through activation of peroxisome proliferator-activated receptor gamma and insulin sensitization

  2015cites this paper
• Food Components Modulate Obesity and Energy Metabolism via the Transcriptional Regulation of Lipid-Sensing Nuclear Receptors.

  2015cites this paper
• ZnO Nanoparticles Upregulates Adipocyte Differentiation in 3T3-L1 Cells

  2015cites this paper
• The antiatherogenic effect of bixin in hypercholesterolemic rabbits is associated to the improvement of lipid profile and to its antioxidant and anti-inflammatory effects

  2015cites this paper
• Effects of Carotenoids on 3T3-L1 Preadipocyte Viability and Differentiation

  2015cites this paper
• PPARα/γ agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats.

  2015cites this paper
• RNA-Seq analysis and annotation of a draft blueberry genome assembly identifies candidate genes involved in fruit ripening, biosynthesis of bioactive compounds, and stage-specific alternative splicing

  2015cites this paper
• Tectorigenin regulates adipogenic differentiation and adipocytokines secretion via PPARγ and IKK/NF-κB signaling

  2015cites this paper
• Aspartame downregulates 3T3-L1 differentiation

  2014cites this paper
• Part of the Special Issue: Metabolism 2014 - Alterations of metabolic pathways as therapeutic targets Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARg): a review

  2014cites this paper
• Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

  2014cites this paper
• Functions, therapeutic applications, and synthesis of retinoids and carotenoids.

  2014cites this paper
• PPARγ-dependent pathway in the growth-inhibitory effects of K562 cells by carotenoids in combination with rosiglitazone.

  2014cites this paper
• Involvement of hepatic peroxisome proliferator-activated receptor α/γ in the therapeutic effect of osthole on high-fat and high-sucrose-induced steatohepatitis in rats.

  2014cites this paper
• candidate genes involved in fruit ripening, biosynthesis of bioactive compounds, and stage- 2 specific alternative splicing 3

  2014cites this paper
• Adipocytes under assault: environmental disruption of adipose physiology.

  2014cites this paper
• Effect of natural compounds on insulin signaling.

  2014cites this paper
• Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats

  2014cites this paper
• Phytochemicals targeting genes relevant for type 2 diabetes.

  2013cites this paper
• Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors.

  2013cites this paper
• Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor γ in 3T3-L1 preadipocytes.

  2013cites this paper
• An Evidence-Based Systematic Review of Annatto (Bixa orellana L.) by the Natural Standard Research Collaboration

  2012cites this paper
• Role of insulin receptor substrate 1 in energy homeostasis in vivo

  2012cites this paper
• Radiation-Induced c-Jun Activation Depends on MEK1-ERK1/2 Signaling Pathway in Microglial Cells

  2012cites this paper
• Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo.

  2012cites this paper
• Natural ligands for nuclear receptors: biology and potential therapeutic applications.

  2012cites this paper
• Next generation sequencing and de novo transcriptome analysis of Costus pictus D. Don, a non-model plant with potent anti-diabetic properties

  2012cites this paper
• An in Vitro Analysis System Using a Fluorescence Protein Reporter for Evaluating Anti-Inflammatory Effects in Macrophages

  2011cites this paper
• Development of a Novel PPARγ Ligand Screening System Using Pinpoint Fluorescence-Probed Protein

  2011cites this paper
• [5-(3-Indol-1-ylpropoxy)-1H-indol-3-yl] Acetic Acid Enhances Adipocyte Differentiation and Glucose Uptake in 3T3-L1 Cells

  2011cites this paper
• Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity.

  2011cites this paper
• Dehydroabietic acid activates peroxisome proliferator-activated receptor-γ and stimulates insulin-dependent glucose uptake into 3T3-L1 adipocytes.

  2011cites this paper
• Phytochemicals as Modulators of PPARs and RXRs

  2011cites this paper
• Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes[S]

  2011cites this paper
• Phytochemicals as Modulators of PPARs and RXRs

  2011cites this paper
• Cornus kousa F.Buerger ex Miquel increases glucose uptake through activation of peroxisome proliferator-activated receptor γ and insulin sensitization.

  2011cites this paper
• Minireview: PPARγ as the target of obesogens

  2011cites this paper
• Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes.

  2011cites this paper
• Six weeks' sebacic acid supplementation improves fasting plasma glucose, HbA1c and glucose tolerance in db/db mice

  2010cites this paper
• New perspectives on innovative drug discovery: an overview.

  2010cites this paper
• Oleanolic acid reduces markers of differentiation in 3T3-L1 adipocytes.

  2010cites this paper
• Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism

  2010cites this paper
• Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues.

  2010cites this paper
• Novel Danshen methoxybenzo[b]furan derivative antagonizing adipogenic differentiation and production of inflammatory adipokines.

  2010cites this paper
• Two-Photon Microscopy for Non-Invasive, Quantitative Monitoring of Stem Cell Differentiation

  2010cites this paper