Structural imaging in the presymptomatic stage of genetically determined parkinsonism.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Neurobiology of Disease

• Publication date

  2010-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.nbd.2010.05.006PMID 20483373
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2006influential reference
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• Depression and neurological disorders

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• Lrrk2 and Lewy body disease

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• Biochemical and pathological characterization of Lrrk2

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• The genetics of Parkinson disease: implications for neurological care

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• LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance.

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• A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease.

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• Valid conjunction inference with the minimum statistic

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• Motor reorganization in asymptomatic carriers of a single mutant Parkin allele: a human model for presymptomatic parkinsonism.

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• PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.

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• Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data.

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• A common LRRK2 mutation in idiopathic Parkinson's disease.

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  2003cited by this paper
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• Progression of nigrostriatal dysfunction in a parkin kindred: an [18F]dopa PET and clinical study.

  2002cited by this paper
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• Clinical and subclinical dopaminergic dysfunction in PARK6‐linked parkinsonism: An 18F‐dopa PET study

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• Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

  2002cited by this paper
• Alterations in the thickness of motor cortical subregions after motor-skill learning and exercise.

  2002cited by this paper
• Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial Parkinsonism associated with mutations in the Parkin gene

  2001cited by this paper
• Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations

  2001cited by this paper
• Ethical principles for medical research involving human subjects.

  2001cited by this paper
• Neuroimaging studies of the hippocampus in schizophrenia

  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Association between early-onset Parkinson's disease and mutations in the parkin gene.

  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Reduced gray matter volume in schizophrenia.

  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• Pallido‐pyramidal degeneration, supranuclear upgaze paresis and dementia: Kufor‐Rakeb syndrome

  1994cited by this paper
• Decreased regional cortical gray matter volume in schizophrenia.

  1994cited by this paper
• Ageing and Parkinson's disease: substantia nigra regional selectivity.

  1991cited by this paper
• Hippocampal neuron number in schizophrenia. A stereological study.

  1991cited by this paper
• Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.

  1973cited by this paper

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  2020cites this paper
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  2015cites this paper
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