Corrigendum: Quantifying the Antiviral Effect of IFN on HIV-1 Replication in Cell Culture

Type-I interferons (IFNs) induce the expression of hundreds of cellular genes, some of which have direct antiviral activities. Although IFNs restrict different steps of HIV replication cycle, their dominant antiviral effect remains unclear. We first quantified the inhibition of HIV replication by IFN in tissue culture, using viruses with different tropism and growth kinetics. By combining experimental and mathematical analyses, we determined quantitative estimates for key parameters of HIV replication and inhibition, and demonstrate that IFN mainly inhibits de novo infection (33% and 47% for a X4- and a R5-strain, respectively), rather than virus production (15% and 6% for the X4 and R5 strains, respectively). This finding is in agreement with patient-derived data analyses.

• Publication year

  2015

• Venue

  Scientific Reports

• Publication date

  2015-10-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/srep15679PMID 26489841PMCID 4614951
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quantifying the Antiviral Effect of IFN on HIV-1 Replication in Cell Culture

  2015cited by this paper

• Computational Prediction and Validation of Tumor-Associated Neoantigens

  2020cites this paper
• Oxidative ionothermal synthesis for micro and macro Zn-based materials

  2020cites this paper
• Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13

  2020cites this paper
• Organoid-based modeling of intestinal development, regeneration, and repair

  2020cites this paper
• Expansion of the CRISPR/Cas Genome-Sculpting Toolbox: Innovations, Applications and Challenges

  2020cites this paper
• Genomics and metatranscriptomics of biogeochemical cycling and degradation of lignin-derived aromatic compounds in thermal swamp sediment

  2020cites this paper
• Transmission electron microscopy characterization of low temperature boron doped silicon epitaxial films

  2020cites this paper
• The relationship between borderline personality features and affective responses to altering emotional context

  2020cites this paper
• A multicenter study on radiomic features from T2‐weighted images of a customized MR pelvic phantom setting the basis for robust radiomic models in clinics

  2020cites this paper
• Is nanoparticle functionalization a versatile approach to meet the challenges of drug and gene delivery?

  2020cites this paper
• In-air EIS sensor for in situ and real-time monitoring of in vitro epithelial cells under air-exposure.

  2020cites this paper
• Effect of composted organic amendments and zinc oxide nanoparticles on growth and cadmium accumulation by wheat; a life cycle study

  2020cites this paper
• High spatially sensitive quantitative phase imaging assisted with deep neural network for classification of human spermatozoa under stressed condition

  2020cites this paper
• Isoforskolin and forskolin attenuate lipopolysaccharide‐induced inflammation through TLR4/MyD88/NF‐κB cascades in human mononuclear leukocytes

  2019cites this paper
• Peptide-Based Therapeutics for Oncology

  2019cites this paper
• Genetically Encoded Voltage Indicators Are Illuminating Subcellular Physiology of the Axon

  2019cites this paper
• Intrinsic default—executive coupling of the creative aging brain

  2019cites this paper
• Configuration Models of Random Hypergraphs and their Applications

  2019cites this paper
• Binning enables efficient host genome reconstruction in cnidarian holobionts

  2018cites this paper
• The therapeutic potential of the insect metalloproteinase inhibitor against infections caused by Pseudomonas aeruginosa

  2018cites this paper
• Challenges and approaches in the discovery of human immunodeficiency virus type‐1 non‐nucleoside reverse transcriptase inhibitors

  2018cites this paper
• On the Dependability and Feasibility of Layperson Ratings of Divergent Thinking

  2018cites this paper
• Molecular signatures of host specificity linked to habitat specialization in Exaiptasia sea anemones

  2018cites this paper
• Review on the current status of polymer degradation: a microbial approach

  2017cites this paper
• Biochar addition induced the same plant responses as elevated CO2 in mine spoil

  2017cites this paper
• A brief review of extrusion‐based tissue scaffold bio‐printing

  2017cites this paper
• Embodied information affects judgements about politicians: The impact of haptic weight sensations and hand cleansing

  2017cites this paper
• Nitrate capture and slow release in biochar amended compost and soil

  2017cites this paper
• Astrocyte Apoptosis and HIV Replication Are Modulated in Host Cells Coinfected with Trypanosoma cruzi

  2017cites this paper
• Frequent and parallel habitat transitions as driver of unbounded radiations in the Cape flora

  2017cites this paper
• The Self-Generative Mind in Education: Review and Future Directions.

  2017cites this paper
• Metabolism-related microRNAs in maternal breast milk are influenced by premature delivery

  2017cites this paper
• Engineering therapeutic antibodies targeting G-protein–coupled receptors

  2016cites this paper
• Timing of transients: quantifying reaching times and transient behavior in complex systems

  2016cites this paper
• A critical review of integration analysis of microbial electrosynthesis (MES) systems with waste biorefineries for the production of biofuel and chemical from reuse of CO2

  2016cites this paper
• Controlling bacterial infections by inhibiting proton-dependent processes.

  2016cites this paper
• Role of the anion on the Interfacial Structure of Ionic Liquids Binary Mixtures at Mercury Interfaces

  2016cites this paper
• RNA-Seq Reveals OTA-Related Gene Transcriptional Changes in Aspergillus carbonarius

  2016cites this paper