Effect of duck egg white peptide-ferrous chelate on iron bioavailability in vivo and structure characterization.

BACKGROUND In order to utilize the industrial by-product 'salted duck egg white' as novel iron additives, the effects of desalted duck egg white peptides-ferrous chelate (DPs-Fe) on the promotion of iron uptake and the structure were investigated. RESULTS Different doses of DPs-Fe were given and iron sulfate (FeSO4 ) was used as a positive control. After three weeks, hemoglobin (Hb), hematocrit (HCT), red blood cells (RBCs), mean corpuscular volume (MCV), serum iron (SI) and serum ferritin (SF) in iron-deficiency anemia (IDA) rats could be significantly (P < 0.05) increased to the normal levels by DPs-Fe. The gene expressions of divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1) and Hepcidin could be regulated by DPs-Fe. Additionally, DPs-Fe was formed during the chelation process and the structure was characterized. Eight crucial iron-chelating peptides of duck egg white peptides (DPs) were identified by HPLC-ESI-MS/MS, such as Pro-Val-Glu-Glu and Arg-Ser-Ser. It indicated that Glu, Asp, Lys, His, Ser, Cys residues might play crucial roles in the chelating of DPs with iron. CONCLUSION DPs-Fe could be a potential iron supplement, and the Glu, Asp, Lys, His played important roles in binding iron and promoting iron uptake. This research expands the understanding of iron uptake by DPs and provides an opportunity for recycling a discarded processing byproduct. © 2018 Society of Chemical Industry.

• Publication year

  2018

• Venue

  The Journal of the Science of Food and Agriculture

• Publication date

  2018-10-31

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/jsfa.9377PMID 30255570
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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