Comparison of risk factors and outcomes of daptomycin‐susceptible and ‐nonsusceptible vancomycin‐resistant enterococcus faecium infections in liver transplant recipients; A reply to Lewis et al

Daptomycin resistance is emerging and is associated with liver transplantation (LTX). The outcomes of patients infected with daptomycin-nonsusceptible-enterococci (DNSE) with minimum-inhibitory-concentrations (MIC)>4 mg/L are unfavorable. As a result, some have recommended reducing the breakpoint for DAP susceptibility in enterococci to ≤2 mg/L. Unfavorable outcomes associated with DNSE are due in part to decreased efficacy of DAP and alternative agents, along with increased toxicity of these regimens for the treatment of VRE. This article is protected by copyright. All rights reserved.

• Publication year

  2018

• Venue

  Transplant Infectious Disease

• Publication date

  2018-10-19

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/tid.13004PMID 30256505
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Comparison of risk factors and outcomes of daptomycin‐susceptible and ‐nonsusceptible vancomycin‐resistant Enterococcus faecium infections in liver transplant recipients

  2018cited by this paper
• Vancomycin-Resistant Enterococcus Colonization and Bacteremia and Hematopoietic Stem Cell Transplantation Outcomes.

  2017cited by this paper
• Temporal trends and risk factors for healthcare-associated vancomycin-resistant enterococci in adults.

  2016cited by this paper
• A single‐center experience with infections due to daptomycin‐nonsusceptible Enterococcus faecium in liver transplant recipients

  2016cited by this paper
• Influence of Minimum Inhibitory Concentration in Clinical Outcomes of Enterococcus faecium Bacteremia Treated With Daptomycin: Is it Time to Change the Breakpoint?

  2016cited by this paper
• Emergence of daptomycin non-susceptibility in colonizing vancomycin-resistant Enterococcus faecium isolates during daptomycin therapy.

  2015cited by this paper
• A Current Perspective on Daptomycin for the Clinical Microbiologist

  2013cited by this paper
• Effects of Antibiotics on Nosocomial Epidemiology of Vancomycin-Resistant Enterococci

  2002cited by this paper
• Performance standards for antimicrobial susceptibility testing

  2001cited by this paper

• Daptomycin perioperative prophylaxis for the prevention of vancomycin‐resistant Enterococcus infection in colonized liver transplant recipients

  2020cites this paper
• Clonal distribution of vancomycin‐resistant Enterococcus faecium in Turkey and the new singleton ST733

  2020cites this paper