ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds

Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein 3-kinase family that activates both c-Jun NH2-terminal kinase and p38 pathways in response to inflammatory cytokines and physicochemical stress. We report that ASK1 deficiency in mice results in dramatic retardation of wounding-induced hair regrowth in skin. Oligonucleotide microarray analysis revealed that expression of several chemotactic and activating factors for macrophages, as well as several macrophage-specific marker genes, was reduced in the skin wound area of ASK1-deficient mice. Intracutaneous transplantation of cytokine-activated bone marrow-derived macrophages strongly induced hair growth in both wild-type and ASK1-deficient mice. These findings indicate that ASK1 is required for wounding-induced infiltration and activation of macrophages, which play central roles in inflammation-dependent hair regrowth in skin.

• Publication year

  2007

• Venue

  Journal of Cell Biology

• Publication date

  2007-03-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.200611015PMID 17389227PMCID 2064076
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases.

  2006cited by this paper
• The ASK1-MAP kinase pathways in immune and stress responses.

  2006cited by this paper
• New mechanisms of skin innate immunity: ASK1‐mediated keratinocyte differentiation regulates the expression of β‐defensins, LL37, and TLR2

  2005cited by this paper
• Socializing with the neighbors: stem cells and their niche.

  2004cited by this paper
• Macrophage-stimulating protein promotes hair growth ex vivo and induces anagen from telogen stage hair follicles in vivo.

  2004cited by this paper
• Global gene expression analysis of gastric cancer by oligonucleotide microarrays.

  2002cited by this paper
• Controls of hair follicle cycling.

  2001cited by this paper
• ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

  2001cited by this paper
• Expression of calcium-binding S100 proteins A4 and A6 in regions of the epithelial sac associated with the onset of hair follicle regeneration.

  2001cited by this paper
• A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages.

  2001cited by this paper
• Apoptosis Signal-regulating Kinase 1 (ASK1) Is an Intracellular Inducer of Keratinocyte Differentiation*

  2001cited by this paper
• Involvement of follicular stem cells in forming not only the follicle but also the epidermis.

  2000cited by this paper
• Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

  1999cited by this paper
• What controls hair follicle cycling?

  1999influential reference
• Highly persistent label-retaining cells in the hair follicles of mice and their fate following induction of anagen.

  1999cited by this paper
• Evidence for apoptosis signal-regulating kinase 1 in the regenerating palatal epithelium upon acute injury.

  1998cited by this paper
• Generation and cyclic remodeling of the hair follicle immune system in mice.

  1998cited by this paper
• ASK1 is essential for JNK/SAPK activation by TRAF2.

  1998cited by this paper
• Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

  1997cited by this paper
• Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes.

  1996cited by this paper
• The effect of wounds on adjacent growing or resting hair follicles in mice.

  1956cited by this paper
• The effect of wounds on adjacent growing or resting hair follicles in mice.

  1956cited by this paper

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• Thioredoxin and Thioredoxin Target Proteins: From Molecular Mechanisms to Functional Significance

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  2012cites this paper
• Multi-layered environmental regulation on the homeostasis of stem cells: the saga of hair growth and alopecia.

  2012cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
• Cell death in the skin

  2009cites this paper
• Complex hair cycle domain patterns and regenerative hair waves in living rodents.

  2008cites this paper
• Scalp psoriasis: a paradigm of "switch-on" mechanism to anagen hair growth?

  2008cites this paper
• Apoptosis signal-regulating kinase 1 in stress and immune response.

  2008cites this paper
• Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling.

  2008cites this paper