Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice

Stimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. This increment was blocked by a specific H1 antagonist mepyramine and to the same extent by the phospholipase C inhibitor NCDC. By using a binding assay H1 histaminergic receptors were detected in autoimmune heart membrane preparations, but this was not observed in normal heart. These data suggest that autoimmune myocardium expressed a functional H1 receptor that could involve a distinctive mechanism operating in the disease.

• Publication year

  1993

• Venue

  Mediators of Inflammation

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/S0962935193000444PMID 18475540PMCID 2365419
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acute Cellular Rejection Following Liver Transplantation: Clinical Pathologic Features and Effect on Outcome

  1992cited by this paper
• Tumor necrosis factor and endotoxin in the pathogenesis of liver and pulmonary injuries after orthotopic liver transplantation in the rat

  1992cited by this paper
• Intraoperative kinetics and regional distribution of interleukin-6 during human liver transplantation.

  1992cited by this paper
• Chagasic IgG stimulates phosphoinositide hydrolysis via neurotransmitter receptor activation: role of calcium.

  1992cited by this paper
• Intraoperative course and prognostic significance of endotoxin, tumor necrosis factor-alpha and interleukin-6 in liver transplant recipients.

  1991cited by this paper
• Cause and timing of first allograft failure in orthotopic liver transplantation: A study of 177 consecutive patients

  1991cited by this paper
• Intraoperative estimation of endotoxin, TNF alpha, and IL-6 in orthotopic liver transplantation and their relation to rejection and postoperative infection.

  1991cited by this paper
• Clinical value of cytokine determination for screening, differentiation, and therapy monitoring of infectious and noninfectious complications after orthotopic liver transplantation.

  1991cited by this paper
• The influence of preservation injury on rejection in the hepatic transplant recipient.

  1990cited by this paper
• Distribution, properties, and functional characteristics of three classes of histamine receptor.

  1990cited by this paper
• The role of tumor necrosis factor in allograft rejection. I. Evidence that elevated levels of tumor necrosis factor-alpha predict rejection following orthotopic liver transplantation.

  1990cited by this paper
• Muscarinic Cholinergic Antibody in Experimental Autoimmune Myocarditis Regulates Cardiac Function

  1990cited by this paper
• Beta-adrenergic cardiac antibody in autoimmune myocarditis.

  1989cited by this paper
• Endotoxemia and human liver transplantation.

  1989cited by this paper
• Liver transplantation (2).

  1989cited by this paper
• Dissociation of phosphoinositide hydrolysis and positive inotropic effect of histamine mediated by H1-receptors in guinea-pig left atria

  1989cited by this paper
• Quantitative endotoxin determination in blood--chromogenic modification of the limulus amebocyte lysate test.

  1988cited by this paper
• Positive inotropic effect of histamine on guinea pig left atrium: H1-receptor-induced stimulation of phosphoinositide turnover.

  1988cited by this paper
• Lymphocytes infiltration induces dysfunction in autoimmune myocarditis: role of SRS-A.

  1988cited by this paper
• Histamine and its lymphocyte-selective derivatives as immune modulators

  1987cited by this paper
• The regulation of expression of major histocompatibility complex products.

  1986cited by this paper
• Potential role of mononuclear cells infiltration on the autoimmune myocardial dysfunction.

  1986cited by this paper
• Inositol trisphosphate, a novel second messenger in cellular signal transduction

  1984cited by this paper
• The role of protein kinase C in cell surface signal transduction and tumour promotion

  1984cited by this paper
• Experimental myocarditis induced in Swiss mice by homologous heart immunization resembles chronic experimental Chagas' heart disease.

  1984cited by this paper
• Membrane phospholipid metabolism and signal transduction for protein phosphorylation.

  1984cited by this paper
• Chapter Three – Factors Regulating Availability of Histamine at Tissue Receptors

  1982cited by this paper
• Chapter Ten – Histamine and Immune Responses

  1982cited by this paper
• Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands.

  1982cited by this paper
• Serine esterase inhibitors block stimulus-induced mobilization of arachidonic acid and phosphatidylinositide-specific phospholipase C activity in platelets.

  1980cited by this paper
• Characteristics of histamine H1-receptors in peripheral tissues labeled with [3H]mepyramine.

  1979cited by this paper
• Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine.

  1978cited by this paper
• Histamine H1-receptors in brain labeled with 3H-mepyramine.

  1978cited by this paper
• Separation of [3H] inositol monophosphates and [3H] inositol on silica gel glass-fiber sheets.

  1976cited by this paper
• The Occurrence of Histamine in Mast Cells

  1966cited by this paper

• Myocardial dysfunction in an experimental model of autoimmune myocarditis: role of IFN-gamma.

  1997cites this paper
• Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjögren's syndrome

  1996cites this paper
• Pharmacological evidence for the existence of different subtypes of muscarinic acetylcholine receptors for phosphoinositide hydrolysis in neonatal versus adult rat atria.

  1995cites this paper
• Increases in cyclic AMP levels couple to H1 receptors in atria from autoimmune myocarditis mice.

  1995cites this paper