Gut Microbiota in Patients with Different Metabolic Statuses: Moscow Study

The aim of this paper was to study gut microbiota composition in patients with different metabolic statuses. Methods: 92 participants aged 25–76 years (26 of whom were men), with confirmed absence of cardiovascular and other chronic diseases (but with the possible presence of cardiovascular risk factors) were included. Carotid ultrasound examinations, 16S rRNA sequencing of stool samples and diet assessments were performed. Statistical analysis was performed using R programming language, 3.1.0. Results: Enterotyping yielded two clusters differentiated by alpha-diversity. Intima-media thickness was higher in the cluster with lower diversity (adj. p < 0.001). Obesity was associated with higher Serratia (adj. p = 0.003) and Prevotella (adj. p < 0.0003) in relative abundance. Abdominal obesity was associated with higher abundance of Serratia (adj. p = 0.004) and Prevotella (adj. p = 0.0008) and lower levels of Oscillospira (adj. p = 0.0005). Glucose metabolism disturbances were associated with higher Blautia (adj. p = 0.0007) and Serratia (adj. p = 0.003) prevalence. Arterial hypertension was associated with high Blautia levels (adj. p = 0.002). The Blautia genus strongly correlated with low resistant starch consumption (adj. p = 0.007). A combination of high-fat diet and elevated Blautia levels was very common for diabetes mellitus type 2 patients (adj. p = 0.0001). Conclusion: The results show that there is a relationship between metabolic changes and higher representation of opportunistic pathogens and low diversity of gut microbiota even in apparently healthy participants.

• Publication year

  2018

• Venue

  Microorganisms

• Publication date

  2018-09-25

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3390/microorganisms6040098PMID 30257444PMCID 6313665
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• High Oleic Acid Peanut Oil and Extra Virgin Olive Oil Supplementation Attenuate Metabolic Syndrome in Rats by Modulating the Gut Microbiota

  2019cited by this paper
• Precision Nutrition and the Microbiome, Part I: Current State of the Science

  2019cited by this paper
• Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project

  2018cited by this paper
• Detection of Increased Plasma Interleukin-6 Levels and Prevalence of Prevotella copri and Bacteroides vulgatus in the Feces of Type 2 Diabetes Patients

  2017cited by this paper
• Gut microbiota and diet in patients with different glucose tolerance

  2015cited by this paper
• Obesity, inflammation, and the gut microbiota.

  2015cited by this paper
• Cytokine response of human mononuclear cells induced by intestinal Clostridium species.

  2013cited by this paper
• Principles of Statistical Genomics

  2012cited by this paper
• The keystone-pathogen hypothesis

  2012cited by this paper
• Microbiota conservation and BMI signatures in adult monozygotic twins

  2012cited by this paper
• On fitting generalized linear mixed‐effects models for binary responses using different statistical packages

  2011cited by this paper
• Enterotypes of the human gut microbiome

  2011cited by this paper
• QIIME allows analysis of high-throughput community sequencing data

  2010cited by this paper
• Gut microbiota in health and disease.

  2010cited by this paper
• Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine.

  2008cited by this paper
• Serratia marcescens Serralysin Induces Inflammatory Responses through Protease-Activated Receptor 2

  2006cited by this paper

• Role of duodenal mucosal resurfacing in controlling diabetes in rats

  2025cites this paper
• Blautia coccoides-derived metabolite trimethylamine-N-oxide exacerbates Alzheimer's disease progression via targeting HIF1α signaling

  2025cites this paper
• The Role of the Gut Microbiome in Type 2 Diabetes Mellitus

  2025cites this paper
• Therapeutic Potential Targeting Gut Microbiota Modulation With Emphasis on Lactobacillus spp. in Common Metabolic Disorders: A Systematic Review

  2025cites this paper
• Comprehensive microbial and clinical profiling of functional constipation: A stratified comparative study of age and constipation subtype

  2025cites this paper
• Gut microbiota and metabolite profiles in HBV cirrhosis with persistent liver enzyme abnormalities

  2025cites this paper
• An Altered Gut Microbiota–Brain Axis in Fragile X Syndrome May Explain Autistic Traits in Some Patients

  2025cites this paper
• Opuntia ficus‐indica fruit consumption improves insulin resistance in mice with diet‐induced obesity

  2025cites this paper
• Temporal and Spatial Dynamics of Tumor–Host Microbiota in Breast Cancer Progression

  2025cites this paper
• In Search of Healthy Ageing: A Microbiome-Based Precision Nutrition Approach for Type 2 Diabetes Prevention

  2025cites this paper
• Alteration of gut microbiota associated with hypertension in children

  2025cites this paper
• Is there a link between the abundance of nitrate-reducing bacteria and arterial hypertension? A systematic review.

  2025cites this paper
• Alterations in gut microbial community structure in obstructive sleep apnea /hypopnea syndrome (OSAHS): a systematic review and meta-analysis.

  2025cites this paper
• High-Coverage Metabolomics Reveals Gut Microbiota-Related Metabolic Traits of Type-2 Diabetes in Serum.

  2025cites this paper
• Mechanisms of formation and progression of cardiovascular pathology in obesity

  2025cites this paper
• Aloe polysaccharides ameliorate obesity-associated cognitive dysfunction in high-fat diet-fed mice by targeting the gut microbiota and intestinal barrier integrity.

  2024cites this paper
• Gut Microbiome and Carotid Artery Intima-Media Thickness: A Narrative Review of the Current Scenario

  2024cites this paper
• Positive impact of indicaxanthin from Opuntia ficus-indica fruit on high-fat diet–induced neuronal damage and gut microbiota dysbiosis

  2024cites this paper
• Effect of fruits granola (Frugra®) consumption on blood pressure reduction and intestinal microbiome in patients undergoing hemodialysis

  2024cites this paper
• Effect of dark sweet cherry (Prunus avium) supplementation on the fecal microbiota, metabolic endotoxemia, and intestinal permeability in obese subjects: a single-blind randomized trial.

  2024cites this paper
• Role of the gut microbiota in aging and maintenance of active longevity. Part 1

  2024cites this paper
• Key Stratification of Microbiota Taxa and Metabolites in the Host Metabolic Health–Disease Balance

  2023cites this paper
• Fecal microbiota transplantation revealed the function of folic acid on reducing abdominal fat deposition in broiler chickens mediated by gut microbiota

  2023cites this paper
• An Optimal Dietary Pattern for Healthy Longevity: Scoping Differencing Review between the Mediterranean and the Japanese Diet.

  2023cites this paper
• Causal relationship between gut microbiota and type 2 diabetes: a two-sample Mendelian randomization study

  2023cites this paper
• Effect of High Fat Diet on Intestinal Gene Expression in Hamster

  2023cites this paper
• The Emerging Role of the Microbiota in Breast Cancer Progression

  2023cites this paper
• The Impact of a Very-Low-Calorie Ketogenic Diet in the Gut Microbiota Composition in Obesity

  2023cites this paper
• Obstructive Sleep Apnea–Induced Hypertension Is Associated With Increased Gut and Neuroinflammation

  2023cites this paper
• Comparative Gut Microbiome Differences between High and Low Aortic Arch Calcification Score in Patients with Chronic Diseases

  2023cites this paper
• Proanthocyanidins: Impact on Gut Microbiota and Intestinal Action Mechanisms in the Prevention and Treatment of Metabolic Syndrome

  2023cites this paper
• Sex discrepancy in establishing mouse visceral obesity model induced by high-fat diet.

  2023cites this paper
• Gut Microbiota Markers and Dietary Habits Associated with Extreme Longevity in Healthy Sardinian Centenarians

  2022cites this paper
• Heat-treated adzuki bean protein hydrolysates reduce obesity in mice fed a high-fat diet via remodeling gut microbiota and improving metabolic function.

  2022cites this paper
• Whole Agrocybe cylindracea Prevented Obesity Linking with Modification of Gut Microbiota and Associated Fecal Metabolites in High-Fat Diet-Fed Mice.

  2022cites this paper
• Gut microbiota in patients with obesity and metabolic disorders — a systematic review

  2022cites this paper
• Unique metabolic pro les of Blautia wexlerae achieve bene cial effects for the control of obesity and type 2 diabetes

  2022cites this paper
• Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus

  2022cites this paper
• Ten-Week Sucralose Consumption Induces Gut Dysbiosis and Altered Glucose and Insulin Levels in Healthy Young Adults

  2022cites this paper
• Gut microbiota and metabonomics used to explore the mechanism of Qing’e Pills in alleviating osteoporosis

  2022cites this paper
• Regulatory effect of gut microbes on blood pressure

  2022cites this paper
• Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

  2022cites this paper
• Sodium humate alters the intestinal microbiome, short-chain fatty acids, eggshell ultrastructure, and egg performance of old laying hens

  2022cites this paper
• Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats

  2022cites this paper
• Roseburia intestinalis Modulates PYY Expression in a New a Multicellular Model including Enteroendocrine Cells

  2022cites this paper
• Current insights in molecular characterization of non-alcoholic fatty liver disease and treatment

  2022cites this paper
• Shades of grey: Coat-colour dependent effect of urbanization on the bacterial microbiome of a wild mammal

  2021cites this paper
• Gut microbiota composition and arterial stiffness measured by pulse wave velocity: case–control study protocol (MIVAS study)

  2021cites this paper
• Anemarrhena asphodeloides modulates gut microbiota and restores pancreatic function in diabetic rats.

  2021cites this paper
• Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

  2021cites this paper
• Assessment of the state of intestinal microbiocenosis based on bacterial endotoxin and plasmalogen in elderly persons with type 2 diabetes mellitus pathology.

  2021cites this paper
• Oral Limonite Supplement Ameliorates Glucose Intolerance in Diabetic and Obese Mice

  2021cites this paper
• Decrease in abundance of bacteria of the genus Bifidobacterium in gut microbiota may be related to pre-eclampsia progression in women from East China

  2021cites this paper
• Subfractional Spectrum of Serum Lipoproteins and Gut Microbiota Composition in Healthy Individuals

  2021cites this paper
• Markers of metabolic health and gut microbiome diversity: findings from two population-based cohort studies

  2021cites this paper
• Shades of grey: host phenotype dependent effect of urbanization on the bacterial microbiome of a wild mammal

  2021cites this paper
• Inulin and Lycium barbarum polysaccharides ameliorate diabetes by enhancing gut barrier via modulating gut microbiota and activating gut mucosal TLR2+ intraepithelial γδ T cells in rats

  2021cites this paper
• Obesity, metabolic health and omics: Current status and future directions

  2021cites this paper
• Preparation, structural characteristics and physiological property of resistant starch.

  2021cites this paper
• A Low to Medium-Shear Extruded Kibble with Greater Resistant Starch Increased Fecal Oligosaccharides, Butyric Acid, and Other Saccharolytic Fermentation By-Products in Dogs

  2021cites this paper
• Association between Gut Microbial Diversity and Carotid Intima-Media Thickness

  2021influential citation
• Gut Microbiome-Based Diagnostic Model to Predict Coronary Artery Disease.

  2020cites this paper
• The phenomenon of intestinal permeability and its association with cardiovascular disease. Current status

  2020cites this paper
• Sick Individuals and Sick (Microbial) Populations: Challenges in Epidemiology and the Microbiome.

  2020cites this paper
• The Gut Microbiome, Aging, and Longevity: A Systematic Review

  2020cites this paper
• Gut microbiota assessment in Moscow long-livers using next generation sequencing

  2020cites this paper
• Characterisation of gut microbiota of obesity and type 2 diabetes in a rodent model

  2020cites this paper
• Феномен проницаемости кишечной стенки и его взаимосвязь с сердечно-сосудистыми заболеваниями. Современные представления о проблеме

  2020cites this paper
• High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms.

  2020cites this paper
• A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Livers

  2020cites this paper
• "Us vs. Them" Pair Housing: Effects on Body Weight, Open Field Behavior, and Gut Microbiota in Rats Selectively Bred on a Taste Phenotype.

  2020cites this paper
• Phocea, Pseudoflavonifractor and Lactobacillus intestinalis: Three Potential Biomarkers of Gut Microbiota That Affect Progression and Complications of Obesity-Induced Type 2 Diabetes Mellitus

  2020cites this paper
• Dietary flaxseed oil rich in omega-3 suppresses severity of type 2 diabetes mellitus via anti-inflammation and modulating gut microbiota in rats

  2020cites this paper
• Precision Nutrition and the Microbiome, Part I: Current State of the Science

  2019cites this paper
• Characteristics of the intestinal flora of specific pathogen free chickens with age.

  2019cites this paper
• Gut Prevotella as a possible biomarker of diet and its eubiotic versus dysbiotic roles: a comprehensive literature review

  2019cites this paper
• High Oleic Acid Peanut Oil and Extra Virgin Olive Oil Supplementation Attenuate Metabolic Syndrome in Rats by Modulating the Gut Microbiota

  2019cites this paper
• A network Involving Gut Microbiota, Circulating Bile Acids and Hepatic Metabolism Genes that Protects Against non-alcoholic Fatty Liver Disease.

  2019cites this paper
• Perilla Oil Supplementation Improves Hypertriglyceridemia and Gut Dysbiosis in Diabetic KKAy Mice

  2018cites this paper
• World Journal of Diabetes

  year unknowncites this paper