Charting the Spread of Salmonella Infection

Liza Gross

Published 2006 in PLoS Biology

ABSTRACT

Every summer, local newspapers warn readers not to eat unchilled potato salad, seared hamburgers, and other picnic fare likely to precipitate an unpleasant encounter with Salmonella enterica bacteria. Yet in recent years, the number and severity of S. enterica cases has risen along with the number of factory farms (where infection can rapidly spread among tens and hundreds of thousands of animals) and the evolution of multi-drug–resistant Salmonella strains. Effective vaccine development and drug therapies depend on understanding how these pathogens behave inside the cell, but technical difficulties have limited scientists’ efforts to directly observe the dynamics of infection in living tissue.

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