An Immunohistochemical Approach to Monitor the Prolactin-induced Activation of the JAK2/STAT5 Pathway in Pancreatic Islets of Langerhans

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Histochemistry and Cytochemistry

• Publication date

  2002-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1177/002215540205000308PMID 11850439
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Multicolor laser scanning confocal immunofluorescence microscopy: practical application and limitations.

  2002cited by this paper
• Growth hormone- and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5).

  2001cited by this paper
• Regulation of Pancreatic Islets by Prolactin, Growth Hormone and Placental Lactogen

  2001cited by this paper
• Bradykinin activates the Janus-activated kinase/signal transducers and activators of transcription (JAK/STAT) pathway in vascular endothelial cells: localization of JAK/STAT signalling proteins in plasmalemmal caveolae.

  2000cited by this paper
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• Regulation of Prolactin Receptor (PRLR) Gene Expression in Insulin-producing Cells

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• Functional rescue of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b.

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• A Sequence of the CIS Gene Promoter Interacts Preferentially with Two Associated STAT5A Dimers: a Distinct Biochemical Difference between STAT5A and STAT5B

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• A Single Amino Acid in the DNA Binding Regions of STAT5A and STAT5B Confers Distinct DNA Binding Specificities*

  1998cited by this paper
• Prolactin regulation of islet-derived INS-1 cells: characteristics and immunocytochemical analysis of STAT5 translocation.

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• Adaptation of Islets of Langerhans to Pregnancy: β-Cell Growth, Enhanced Insulin Secretion and the Role of Lactogenic Hormones

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• Glucokinase, hexokinase, glucose transporter 2, and glucose metabolism in islets during pregnancy and prolactin-treated islets in vitro: mechanisms for long term up-regulation of islets.

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• Number and size of islets of Langerhans in pregnant, human growth hormone-expressing transgenic, and pituitary dwarf mice: effect of lactogenic hormones.

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• Transcription Factors Stat3 and Stat5b Are Present in Rat Liver Nuclei Late in an Acute Phase Response and Bind Interleukin-6 Response Elements (*)

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• c-Jun regulates postpartum β-cell apoptosis and survival downstream of prolactin signaling.

  2025cites this paper
• Prolactin receptor localization and dynamics: Insights from quantitative imaging and mathematical modeling

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• ACSS2 mediates an epigenetic pathway to regulate β-cell adaptation during gestation in mice

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• Kisspeptin upregulates β-cell serotonin production during pregnancy

  2023cites this paper
• PRL/PRLR Can Promote Insulin Resistance by Activating the JAK2/STAT5 Signaling Pathway

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• Systematic Bayesian Posterior Analysis Guided by Kullback-Leibler Divergence Facilitates Hypothesis Formation.

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• Systematic Bayesian Posterior Analysis Facilitates Hypothesis Formation and Guides Investigation of Pancreatic Beta Cell Signaling

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• Beta-Cell Adaptation to Pregnancy – Role of Calcium Dynamics

  2022cites this paper
• Phosphatases are predicted to govern prolactin-mediated JAK-STAT signaling in pancreatic beta cells

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• Pregnancy‐induced changes in β‐cell function: what are the key players?

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• Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling

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• Morphological and functional adaptations of pancreatic alpha-cells during late pregnancy in the mouse.

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• Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets.

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• Pancreatic prolactin receptor signaling regulates maternal glucose homeostasis.

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• Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus

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• Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets

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• Piecing together the puzzle of pancreatic islet adaptation in pregnancy

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• Short-term low-protein diet during pregnancy alters islet area and protein content of phosphatidylinositol 3-kinase pathway in rats.

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• EGFR Signaling Promotes β-Cell Proliferation and Survivin Expression during Pregnancy

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• MafA Is Required for Postnatal Proliferation of Pancreatic β-Cells

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• Estudo do papel da proteína HSP27/25 na ação da prolactina humana recombinante em células beta pancreáticas

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• Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy

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• Recombinant human prolactin promotes human beta cell survival via inhibition of extrinsic and intrinsic apoptosis pathways

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• Prolactin receptors are critical to the adaptation of islets to pregnancy.

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• Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy.

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• STAT5 activity in pancreatic β-cells

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• Rapamycin Impairs In Vivo Proliferation of Islet Beta-Cells

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• The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging.

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• Beneficial effects of prolactin and laminin on human pancreatic islet-cell cultures.

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