Walking the Walk from Genes through Telomere Maintenance to Cancer Risk

Recent studies have shown associations between human population single-nucleotide polymorphisms (SNP) and white blood cell telomere shortness; independently, telomere shortness has been associated with higher risks of various cancers. However, no single previous study simultaneously linked a given SNP both with telomere length and reduced risk of cancer. In this issue of the journal (beginning on page 514), Gu and colleagues report four new SNPs associated, in three cohorts, with telomere length. One of these SNPs predicted risk for bladder cancer, an effect partially mediated by telomere length. Interventions that could forestall telomere shortening should be explored for their potential to reduce cancer risks. Cancer Prev Res; 4(4); 473–5. ©2011 AACR.

• Publication year

  2011

• Venue

  Cancer Prevention Research

• Publication date

  2011-02-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1940-6207.CAPR-11-0066PMID 21460394
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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