Cognitive deficits in children of alcoholics: At risk before the first sip!

Background: High family loading for alcoholism, early onset of alcohol use and childhood disinhibitory behaviors, persisting into adulthood, increase the susceptibility to alcoholism. At the psychophysiology level, reduced amplitude of the P300 component of the Evoked Response Potential is associated with externalizing psychopathology in children. Children of alcoholics have reduced P300 amplitudes. Preliminary data suggests a developmental lag phenomenon in the maturation of the P300. Aims: The study compares the amplitude and topography of the P300 generated in response to a visual task, between subjects at high risk (HR) and those at low risk (LR) for alcoholism and its relation to externalizing behaviors. Results: HR subjects have lower P300 amplitudes over frontal brain areas. Differences are greater in young, tending to converge with increasing age. There is a strong association between this reduced brain activation and an excess of externalizing behaviors in HR individuals. Conclusion: A maturational lag in brain development causing central nervous system disinhibition and externalizing behaviors may underlie the susceptibility to alcoholism.

• Publication year

  2007

• Venue

  Indian Journal of Psychiatry

• Publication date

  2007-07-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.4103/0019-5545.37319PMID 20661384PMCID 2902091
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CLINICAL STUDY: Abnormalities in cortical and transcallosal inhibitory mechanisms in subjects at high risk for alcohol dependence: a TMS study

  2008cited by this paper
• IMAGING STUDY: Gray matter volume abnormalities and externalizing symptoms in subjects at high risk for alcohol dependence

  2007cited by this paper
• Reduced frontal lobe activity in subjects with high impulsivity and alcoholism.

  2007cited by this paper
• Differences in impulsivity and sensation seeking between early- and late-onset alcoholics.

  2006cited by this paper
• The utility of neurophysiological markers in the study of alcoholism.

  2005influential reference
• Age of onset of drinking and the use of alcohol in adulthood: a follow-up study from age 8-42 for females and males.

  2005cited by this paper
• Paternal Alcoholism and Offspring Conduct Disorder: Evidence for the ‘Common Genes’ Hypothesis

  2005cited by this paper
• Resting EEG in offspring of male alcoholics: beta frequencies.

  2004cited by this paper
• Trajectories of Alcohol Use and Electrophysiological and Morphological Indices of Brain Development: Distinguishing Causes from Consequences

  2004cited by this paper
• The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women.

  2003cited by this paper
• Brain maturation and subtypes of conduct disorder: interactive effects on p300 amplitude and topography in male adolescents.

  2003cited by this paper
• G x E: a NIAAA workshop on gene-environment interactions.

  2003cited by this paper
• P3 event-related potential amplitude and the risk for disinhibitory disorders in adolescent boys.

  2002cited by this paper
• Topographic distribution and developmental timecourse of auditory event-related potentials in two subtypes of attention-deficit hyperactivity disorder.

  2001cited by this paper
• Anatomical MRI of the developing human brain: what have we learned?

  2001cited by this paper
• P3 event-related potential, dopamine D2 receptor A1 allele, and sensation-seeking in adult children of alcoholics.

  2001cited by this paper
• Psychiatric aspects of impulsivity.

  2001cited by this paper
• Origins and consequences of age at first drink. II. Familial risk and heritability.

  2001cited by this paper
• Imaging Normal and Abnormal Brain Development: New Perspectives for Child Psychiatry

  2001cited by this paper
• Developmental sequence from disruptive behavior diagnosis to adolescent alcohol dependence.

  2001cited by this paper
• Substance dependence and externalizing psychopathology in adolescent boys with small, average, or large P300 event-related potential amplitude.

  1999cited by this paper
• Reduced P300 responses in criminal psychopaths during a visual oddball task.

  1999cited by this paper
• Developmental delay in P300 production in children at high risk for developing alcohol-related disorders.

  1999cited by this paper
• Genetics of alcoholism and substance abuse.

  1999cited by this paper
• Impulsivity: a discussion of clinical and experimental findings

  1999cited by this paper
• P300 decrements in teenagers with conduct problems: implications for substance abuse risk and brain development.

  1999cited by this paper
• What is inherited in the predisposition toward alcoholism? A proposed model.

  1999cited by this paper
• Heritability of event-related brain potentials in families with a history of alcoholism.

  1999cited by this paper
• Combined event‐related fMRI and EEG evidence for temporal—parietal cortex activation during target detection

  1997cited by this paper
• P300 amplitudes vary inversely with continuum of risk in first degree male relatives of alcoholics

  1995cited by this paper
• Frontal P300 decrements in antisocial personality disorder.

  1994cited by this paper
• Meta-analysis of P300 amplitude from males at risk for alcoholism.

  1994cited by this paper
• A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA.

  1994cited by this paper
• Reduced P3 amplitudes are associated with both a family history of alcoholism and antisocial personality disorder.

  1994cited by this paper
• Personality and disinhibitory psychopathology: alcoholism and antisocial personality disorder.

  1994cited by this paper
• Assessing the development of automatic processing: an application of dual-task and event-related brain potential methodologies.

  1988cited by this paper
• The endogenous components of the event-related potential--a diagnostic tool?

  1986cited by this paper
• Event-related brain potentials in boys at risk for alcoholism.

  1984cited by this paper
• Effects of preparatory set and task demands on auditory event-related potentials.

  1982cited by this paper
• Inheritance of alcohol abuse. Cross-fostering analysis of adopted men.

  1981cited by this paper
• Disinhibitory psychopathology: a new perspective and a model for research.

  1980cited by this paper
• The Binomial Distribution of Right, Mixed and Left Handedness

  1967cited by this paper
• The visually evoked potential in twins.

  1965cited by this paper

• Perspectives on addiction-related problems in India.

  2024cites this paper
• Psychosocial Impact on Primary Caregivers of Patients with Alcohol Related Disorders: A Review Based Indian Perspective

  2024cites this paper
• Association between Parent-Reported Executive Functions and Self-Reported Emotional Problems among Adolescent Offspring of Fathers with Alcohol-Dependence

  2022cites this paper
• Risk Factors and Lifestyle Habits Leading to Alcohol Consumption from Youth

  2022cites this paper
• Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol

  2020cites this paper
• Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science

  2018cites this paper
• Cognitive and behavioural dispositions in offspring at high risk for alcoholism.

  2018cites this paper
• Influence of socio-cultural factors on the emotional problems among college going young-adult children of parents with alcoholism: A study from South India.

  2018cites this paper
• Effect Of Gender On Anxiety And Self Esteem Of Children Of alcoholics

  2018cites this paper
• Brain Electrical Oscillation Signature Profiling BEOS

  2017cites this paper
• A Study on Insecurity Feelings Faced By the Children of Alcoholics Ms

  2017cites this paper
• Psychopathology and Neuropsychological Characteristics of Children of Men with Alcohol Dependence

  2017cites this paper
• Brain Electrical Oscillations Signature Profiling ( BEOS ) for Measuring the Process of Remembrance

  2017cites this paper
• Externalizing behavior and impulsivity in the children of alcoholics: A case-control study

  2016cites this paper
• Addictions in India

  2016cites this paper
• From Nihilism to Hope: Reframing the Concept of Addiction

  2016cites this paper
• THE IMPACT ON PSYCHOPATHOLOGY AND NEURODEVELOPMENT OF CHILDREN’S OF ALCOHOL DEPENDENT FATHER

  2015cites this paper
• Addiction Research in India

  2015cites this paper
• The Development of the Role Identification Scale for Adult Children of Alcoholic Fathers

  2014cites this paper
• The efficacy of atomoxetine as adjunctive treatment for co-morbid substance use disorders and externalizing symptoms.

  2013cites this paper
• Effects of parental alcohol misuse on children and adolescents: A literature review

  2013influential citation
• Blunted feedback processing during risky decision making in adolescents with a parental history of substance use disorders

  2013cites this paper
• The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation.

  2012cites this paper
• Exploring the Alcohol Deprivation Effect in Withdrawal-Seizure Prone and Withdrawal-Seizure Resistant Mice

  2012cites this paper
• Cognitive psychiatry in India

  2010influential citation
• Children of men with alcohol dependence: Psychopathology, neurodevelopment and family environment

  2010influential citation
• Substance use and addiction research in India

  2010cites this paper
• Biological investigations in Indian psychiatry

  2010cites this paper