Food-dependent, exercise-induced anaphylaxis in a patient allergic to peach

Determining the single factor that triggered anaphylactic shock can be challenging. We present an interesting case of a 25-year-old female patient with recurrent anaphylactic reactions developing after eating various foods, particularly in presence of co-factors of allergic reactions. Symptoms occurred after consumption of various kinds of foods – peach, pancakes with cottage cheese and fruit, a meal from a Chinese restaurant – all eaten on other occasions without symptoms. During diagnosis, skin prick tests were negative for all tested allergen extracts (both inhalatory and food) from Allergopharma. Prick by prick tests were positive for the peach – wheal diameter – 6 mm, nectarine – 4 mm (histamine 4 mm, negative control 0 mm). Increased levels of asIgE were found for allergens of peach (0.55 kU/L).Open challenge test with one mid-size peach combined with the physical exercise challenge test was positive. ImmunoCAP ISAC test indicated increased levels of IgE specific for the lipid transfer protein (LTP) for walnut (nJug r 3), peach (Pru p 3), wheat (rTri a 14) and plane tree (rPla a 3). The patient was diagnosed with food-dependent, exercise-induced anaphylaxis associated with an allergy to lipid transport proteins (LTPs).

• Publication year

  2018

• Venue

  International Journal of Immunopathology and Pharmacology

• Publication date

  2018-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1177/2058738418803154PMID 30270687PMCID 6168719
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immunotherapy with Native Molecule rather than Hypoallergenic Variant of Pru p 3, the Major Peach Allergen, Shows Beneficial Effects in Mice

  2018cited by this paper
• Immunological Changes Induced in Peach Allergy Patients with Systemic Reactions by Pru p 3 Sublingual Immunotherapy

  2018cited by this paper
• Recurrent anaphylaxis in patient allergic to eggplant - a Lipid transfer protein (LTP) syndrome.

  2018cited by this paper
• The Role of Food Challenges in Clinical Practice.

  2018cited by this paper
• Diagnostic Value of Tryptase in Food Allergic Reactions: A Prospective Study of 160 Adult Peanut Challenges.

  2018cited by this paper
• The clinical and immunological effects of Pru p 3 sublingual immunotherapy on peach and peanut allergy in patients with systemic reactions

  2017cited by this paper
• The diagnosis and management of food allergies. Position paper of the Food Allergy Section the Polish Society of Allergology

  2017cited by this paper
• [Food-dependent exercise-induced anaphylaxis : a stepwise diagnosis].

  2017cited by this paper
• The clinical spectrum of omega‐5‐gliadin allergy

  2016cited by this paper
• Disease spectrum in patients with elevated serum tryptase levels

  2015cited by this paper
• Using a gluten oral food challenge protocol to improve diagnosis of wheat-dependent exercise-induced anaphylaxis.

  2015cited by this paper
• Isoform identification, recombinant production and characterization of the allergen lipid transfer protein 1 from pear (Pyr c 3).

  2012cited by this paper
• Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant‐foods and pollens

  2012cited by this paper
• Are IgE Levels to Foods other than Rosaceae Predictive of Allergy in Lipid Transfer Protein-Hypersensitive Patients?

  2010cited by this paper
• Allergies to fruits and vegetables

  2008cited by this paper
• Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some cases

  2007cited by this paper
• Detection of Some Safe Plant-Derived Foods for LTP-Allergic Patients

  2007cited by this paper
• Maturity and storage influence on the apple (Malus domestica) allergen Mal d 3, a nonspecific lipid transfer protein.

  2006cited by this paper
• Wine Anaphylaxis in a German Patient: IgE-Mediated Allergy against a Lipid Transfer Protein of Grapes

  2005cited by this paper
• Clinical role of lipid transfer proteins in food allergy.

  2004cited by this paper
• Analysis of the heat stability of lipid transfer protein from apple.

  2003cited by this paper
• Patterns of Reactivity to Lipid Transfer Proteins of Plant Foods and Artemisia Pollen: An in vivo Study

  2002cited by this paper

• Current State of Celery Allergy: Is Discovering Api g 7 a Milestone in Diagnosing Celeriac-Allergic Patients?

  2025cites this paper
• Phenotypes and Endotypes of Peach Allergy: What Is New?

  2022cites this paper
• Food-dependent Exercise-induced Wheals, Angioedema, and Anaphylaxis: A Systematic Review.

  2022cites this paper
• The role of small intestinal bacterial overgrowth in food intolerances

  2021cites this paper
• The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area

  2021cites this paper
• Exercise induced anaphylaxis in kiwi allergic patient: case report

  2021cites this paper
• Design, Assessment, and Validation of a Questionnaire to Estimate Food-Dependent Exercise-Induced Anaphylaxis Prevalence in Latin American Population

  2020cites this paper
• The Use of Molecular Allergy Diagnosis in Anaphylaxis: a Literature Review

  2019cites this paper
• Diagnosis and prevention of food-dependent exercise-induced anaphylaxis

  2019cites this paper