Aerobic Catalytic Features in Photoredox- and Copper-Catalyzed Iodolactonization Reactions.

Mechanistic evaluations and comparison of two important aerobic catalytic oxidation processes, aerobic copper catalysis and photoredox catalysis, are performed. Interesting and distinct catalytic behaviors were observed for a common reaction of iodolactonization of alkenoic acids. Namely, the aerobic copper catalysis requires the formation of a copper carboxylate, whereas the aerobic photoredox catalysis requires the addition of proton sources to proceed to completion. Furthermore, the iodolactone products obtained from these catalytic processes are extensively derivatized to a number of functionalized lactones, including aryl lactones generated from the nickel-catalyzed reductive coupling with aryl halides.

• Publication year

  2018

• Venue

  Organic Letters

• Publication date

  2018-10-02

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.orglett.8b02771PMID 30277403
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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