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Novel core-shell dextran hybrid nanosystem for anti-viral drug delivery.

K. Joshy,A. George,S. Snigdha,B. Joseph,N. Kalarikkal,L. Pothen,Sabu Thomas

Published 2018 in Materials Science and Engineering C: Materials for Biological Applications

ABSTRACT

Zidovudine (AZT) is an antiviral drug extensively used for combating the global pandemic- HIV/AIDS. However, its uses are overshadowed by its short half -life, poor aqueous solubility and inability to cross physiological barriers. This study highlights a nanosystem consisting of dextran and stearic acid for AZT delivery. This hybrid nanoparticle was prepared by double emulsion solvent evaporation method. The morphological analysis of the prepared nanoparticles was carried out by transmission electron microscopy (TEM) and structural analysis through FTIR spectroscopy. Haemolysis, blood cell aggregation and cytotoxicity evaluations were also performed. These biological evaluations indicated that the nanoparticles were compatible and fluorescence microscopy studies demonstrated increased cellular internalization of drug loaded hybrid nanoparticles when compared with free drug molecules. The experimental outcomes indicate that the prepared nanoparticles are highly biocompatible haemocompatible and effective in getting internalized into cells of neural origin. These results highlight the feasibility and efficacy of the hybrid nanoparticles for effective delivery of zidovudine.

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