The avascular zone and neuronal remodeling of the fovea in Parkinson disease

Inner foveal thinning and intracellular alpha‐synuclein were demonstrated in the retina in Parkinson disease. While pathognomonic alpha‐synuclein is associated with embryonic dopaminergic (DA) neurons, postmortem studies in the nervous system and retina show prominent effect also in non‐DA neurons. We evaluated foveal capillaries and foveal thickness in 23 Parkinson disease subjects and 13 healthy controls using retinal fluorescein angiography and optical coherence tomography. The size of the foveal avascular zone inversely correlates with foveal thinning. Foveal thinning highly correlates with motor impairment and also disease duration. Quantifying capillary and neuronal remodeling could serve as biological markers.

• Publication year

  2015

• Venue

  Annals of Clinical and Translational Neurology

• Publication date

  2015-01-08

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/acn3.146PMID 25750923PMCID 4338959
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects.

  2014cited by this paper
• α‐synuclein in the inner retina in parkinson disease

  2014cited by this paper
• Venturing into the no‐man's land of the retina in Parkinson's disease

  2014cited by this paper
• Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases.

  2014cited by this paper
• Remodeling of the fovea in Parkinson disease

  2013cited by this paper
• Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease

  2013cited by this paper
• Relationship between the foveal avascular zone and foveal pit morphology.

  2012cited by this paper
• Foveal Avascular Zone and Its Relationship to Foveal Pit Shape

  2012cited by this paper
• Evidence for angiogenesis in Parkinson’s disease, incidental Lewy body disease, and progressive supranuclear palsy

  2011cited by this paper
• Retinal fractals and acute lacunar stroke

  2010cited by this paper
• Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology.

  2006cited by this paper
• Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease

  2006cited by this paper
• Foveal avascular zone in diabetic retinopathy: quantitative vs qualitative assessment

  2005cited by this paper
• Changes in vascularization in substantia nigra pars compacta of monkeys rendered parkinsonian

  2005influential reference
• Capillary density and retinal diameter measurements and their impact on altered retinal circulation in glaucoma: a digital fluorescein angiographic study

  2002cited by this paper
• Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease

  2002cited by this paper
• Pathological features of cerebral cortical capillaries are doubled in Alzheimer’s disease and Parkinson’s disease

  2000cited by this paper
• Blood vessels change in the mesencephalon of patients with Parkinson's disease.

  1999cited by this paper
• Blood vessels change in the mesencephalon of patients with Parkinson's disease.

  1999cited by this paper
• Neurobiology of retinal dopamine in relation to degenerative states of the tissue.

  1997cited by this paper
• About the authors

  1995cited by this paper
• The acute retinal histopathology of MPTP.

  1992cited by this paper
• Spatial geometry of the dopamine innervation in the avascular area of the human fovea

  1991cited by this paper
• Antibodies to human leucocyte antigens indicate subpopulations of microglia in human retina

  1991cited by this paper
• ANGIO-ARCHITECTURE OF THE SUBSTANTIA NIGRA AND ITS PATHOGENIC SIGNIFICANCE

  1936cited by this paper

• Exploration of the Value of Optical Coherence Tomography (OCT) and OCT Angiography in Differentiating Between Major Depressive Disorder and Borderline Personality Disorder

  2025cites this paper
• Retinal capillary plexus in Parkinson's disease using optical coherence tomography angiography.

  2024cites this paper
• Ultra-Widefield Imaging of the Retinal Macrovasculature in Parkinson Disease Versus Controls With Normal Cognition Using Alpha-Shapes Analysis

  2024cites this paper
• Reduced Thickness of the Retina in de novo Parkinson’s Disease Shows A Distinct Pattern, Different from Glaucoma

  2024cites this paper
• Inner retinal layers’ alterations of the microvasculature in early stages of Parkinson’s disease: a cross sectional study

  2023cites this paper
• Optical coherence tomography angiography in Parkinson’s disease: a systematic review and meta-analysis

  2023cites this paper
• Deep learning predicts prevalent and incident Parkinson’s disease from UK Biobank fundus imaging

  2023cites this paper
• Retinal Vessel Density and Retinal Nerve Fiber Layer Thickness: A Prospective Study of One-Year Follow-Up of Patients with Parkinson’s Disease

  2023cites this paper
• Visual Dysfunction in Parkinson’s Disease

  2023cites this paper
• Retinal Microvascular Density Was Associated With the Clinical Progression of Parkinson’s Disease

  2022cites this paper
• Quantitative analysis of related parameters of retinal nerve fiber layer and ganglion cell complex thickness in patients with different degrees of Parkinson's disease

  2022cites this paper
• Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease

  2022cites this paper
• Foveal Remodeling of Retinal Microvasculature in Parkinson’s Disease

  2021cites this paper
• Past, present and future role of retinal imaging in neurodegenerative disease.

  2021cites this paper
• Tears - more to them than meets the eye: why tears are a good source of biomarkers in Parkinson's disease.

  2020cites this paper
• Comparison of macular structural and vascular changes in neuromyelitis optica spectrum disorder and primary open angle glaucoma: a cross-sectional study

  2020cites this paper
• OCT in Parkinson’s Disease and Related Disorders

  2020cites this paper
• Optical Coherence Tomography Angiography in Neuroophthalmology Review

  2020cites this paper
• Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus

  2020cites this paper
• Optical coherence tomography angiography-derived flow density: a review of the influencing factors

  2019cites this paper
• Optical coherence tomography in the investigation of systemic neurologic disease

  2019cites this paper
• Retinal α-synuclein deposits in Parkinson’s disease patients and animal models

  2019cites this paper
• [Optical coherence tomography angiography in neuronal diseases : Preliminary findings].

  2019cites this paper
• Optische Kohärenztomographie-Angiographie bei neuronalen Erkrankungen

  2019cites this paper
• Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases

  2019cites this paper
• The role of Optical Coherence Tomography in Parkinsonism: A critical review.

  2019cites this paper
• CHARACTERIZATION BY FRACTAL DIMENSION ANALYSIS OF THE RETINAL CAPILLARY NETWORK IN PARKINSON DISEASE.

  2019cites this paper
• Evaluation of Visual Evoked Potential and Optical Coherence Tomography Results in Idiopathic Parkinson’s Disease Patients

  2018cites this paper
• Oculo‐visual abnormalities in Parkinson's disease: Possible value as biomarkers

  2018cites this paper
• The Retina in Multiple System Atrophy: Systematic Review and Meta-Analysis

  2017cites this paper
• DIFFERENTIAL MACULAR FEATURES ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN EYES WITH CHOROIDAL NEVUS AND MELANOMA

  2017cites this paper
• A combination of retinal morphology and visual electrophysiology testing increases diagnostic yield in Parkinson's disease.

  2016cites this paper
• In Vivo Morphology of the Optic Nerve and Retina in Patients With Parkinson's Disease.

  2016cites this paper
• Optical Coherence Tomography in Neurodegenerative Disorders

  2016cites this paper
• Subclinical primary retinal pathology in neuromyelitis optica spectrum disorder

  2016cites this paper
• Ratiometric analysis of in vivo retinal layer thicknesses in multiple sclerosis

  2016cites this paper
• Visual Acuity Is Correlated with the Area of the Foveal Avascular Zone in Diabetic Retinopathy and Retinal Vein Occlusion.

  2016cites this paper
• Visual dysfunction in Parkinson’s disease

  2016cites this paper
• The relevance of pre-motor symptoms in Parkinson’s disease

  2015cites this paper