In enterovirus 71 encephalitis with cardio-respiratory compromise, elevated interleukin 1β, interleukin 1 receptor antagonist, and granulocyte colony-stimulating factor levels are markers of poor prognosis.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Infectious Diseases

• Publication date

  2012-09-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/infdis/jis446PMID 22829643
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Granulocyte Colony-Stimulating Factor Enhances Arteriogenesis and Ameliorates Cerebral Damage in a Mouse Model of Ischemic Stroke

  2011cited by this paper
• Differences in Cerebral Extracellular Response of Interleukin-1β, Interleukin-6, and Interleukin-10 After Subarachnoid Hemorrhage or Severe Head Trauma in Humans

  2011cited by this paper
• Granulocyte-Colony Stimulating Factor (G-CSF) in Stroke Patients with Concomitant Vascular Disease—A Randomized Controlled Trial

  2011cited by this paper
• The Cytokine Response to Human Traumatic Brain Injury: Temporal Profiles and Evidence for Cerebral Parenchymal Production

  2011cited by this paper
• G-CSF for stem cell therapy in acute myocardial infarction: friend or foe?

  2011cited by this paper
• Clinical features, diagnosis, and management of enterovirus 71.

  2010cited by this paper
• Limiting adverse cardiac remodeling after acute myocardial infarction by blocking interleukin-1.

  2010cited by this paper
• Valsartan inefficacy or ill-effects of concomitant medications!

  2010cited by this paper
• Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study

  2010cited by this paper
• Virology, epidemiology, pathogenesis, and control of enterovirus 71.

  2010cited by this paper
• Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study).

  2010cited by this paper
• Enterovirus 71: epidemiology, pathogenesis and management

  2009cited by this paper
• Qiliqiangxin regulates the balance between tumor necrosis factor-alpha and interleukin-10 and improves cardiac function in rats with myocardial infarction.

  2009cited by this paper
• Identification and validation of clinical predictors for the risk of neurological involvement in children with hand, foot, and mouth disease in Sarawak

  2009cited by this paper
• Anakinra in Experimental Acute Myocardial Infarction—Does Dosage or Duration of Treatment Matter?

  2009cited by this paper
• Inflammatory Markers and Poor Outcome after Stroke: A Prospective Cohort Study and Systematic Review of Interleukin-6

  2009cited by this paper
• Lowering interleukin-1 activity with anakinra improves myocardial deformation in rheumatoid arthritis

  2009cited by this paper
• Apoptosis in cardiac myocytes during the early stage after severe burn.

  2008cited by this paper
• Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA-HEART Study)

  2008cited by this paper
• Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis.

  2008cited by this paper
• Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity.

  2007cited by this paper
• The proinflammatory cytokines TNF-alpha and IL-1 beta impair economy of contraction in human myocardium.

  2007cited by this paper
• The proinflammatory cytokines TNF-α and IL-1β impair economy of contraction in human myocardium

  2007cited by this paper
• Outbreak of neurologic enterovirus type 71 disease: a diagnostic challenge.

  2007cited by this paper
• Experimental Stroke Induces Massive, Rapid Activation of the Peripheral Immune System

  2006cited by this paper
• Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled trial

  2006cited by this paper
• Cardiac Molecular Signaling After Burn Trauma

  2006cited by this paper
• A Novel Neuroprotectant Granulocyte-Colony Stimulating Factor

  2006cited by this paper
• CNS immune privilege: hiding in plain sight

  2006cited by this paper
• Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis.

  2006cited by this paper
• Pretreatment Intracerebral and Peripheral Blood Immune Responses in Vietnamese Adults with Tuberculous Meningitis: Diagnostic Value and Relationship to Disease Severity and Outcome

  2006cited by this paper
• Interleukin‐1 receptor antagonist levels correlate with extent of myocardial loss in patients with acute myocardial infarction

  2005cited by this paper
• Genomewide analysis of the host response to malaria in Kenyan children.

  2005cited by this paper
• Prevention of Left Ventricular Remodeling With Granulocyte Colony-Stimulating Factor After Acute Myocardial Infarction: Final 1-year Results of the Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Granulocyte Colony-Stimulating Factor (FIRSTLINE-

  2005cited by this paper
• Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

  2004cited by this paper
• Cardiac complications of enterovirus rhombencephalitis

  2004cited by this paper
• Proinflammatory cytokines and chemokines in humans with Japanese encephalitis.

  2004cited by this paper
• Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system.

  2003influential reference
• Cardiac troponin I: a reliable marker and early myocardial involvement with meningoencephalitis after fatal enterovirus-71 infection.

  2003cited by this paper
• Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema.

  2003cited by this paper
• Different proinflammatory reactions in fatal and non‐fatal enterovirus 71 infections: implications for early recognition and therapy

  2002cited by this paper
• Neurologic complications in children with enterovirus 71 infection.

  1999cited by this paper
• Treatment of experimental viral myocarditis with interleukin-10.

  1999cited by this paper
• Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease.

  1999cited by this paper
• Treatment of psoriasis with interleukin-10.

  1998cited by this paper
• A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation.

  1998cited by this paper
• Two‐way communication pathways between the brain and the immune system

  1997cited by this paper
• Elevated Plasma Levels of Interleukin-1 Receptor Antagonist and Interleukin-10 in Patients with Acute Myocardial Infarction

  1997cited by this paper
• Cerebrospinal fluid interleukin-1 receptor antagonist and tumor necrosis factor-alpha following subarachnoid hemorrhage.

  1997cited by this paper
• Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1.

  1996cited by this paper
• Central endotoxin induces different patterns of interleukin (IL)-1 beta and IL-6 messenger ribonucleic acid expression and IL-6 secretion in the brain and periphery.

  1995cited by this paper
• Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes

  1991cited by this paper

• Neutral Sphingomyelinase 2 Knockdown Attenuates Disease Severity and Modulates Immune Responses in Enterovirus A71-Infected Mice.

  2026cites this paper
• Severe enterovirus A71 pathogenesis and immune responses in human nucleolin transgenic mice

  2025cites this paper
• A RNA-seq-based study on differentially expressed genes related to the Inner Mongolia EV71 C33λ strain that invades Vero cells

  2024cites this paper
• Modulation of plasmacytoid dendritic cell and CD4+ T cell differentiation accompanied by upregulation of the cholinergic anti-inflammatory pathway induced by enterovirus 71

  2024cites this paper
• Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

  2023cites this paper
• TBK1 and IRF3 are potential therapeutic targets in Enterovirus A71-associated diseases

  2023cites this paper
• The upregulation of peripheral blood polyamine metabolites spermidine and spermine in children with hand, foot, mouth disease is related to enterovirus 71 capsid protein VP1, but not VP4

  2023cites this paper
• Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

  2023cites this paper
• Cell membrane-bound toll-like receptor-1/2/4/6 monomers and -2 heterodimer inhibit enterovirus 71 replication by activating the antiviral innate response

  2023cites this paper
• Study some immunological parameters in pediatric meningitis

  2022cites this paper
• Role of Non-Coding RNA in Neurological Complications Associated With Enterovirus 71

  2022cites this paper
• Cytokines and chemokines profile in encephalitis patients: A meta-analysis

  2022cites this paper
• Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis

  2022cites this paper
• Does enterovirus 71 urge for effective vaccine control strategies? Challenges and current opinion

  2022cites this paper
• High Throughput Screening of Differentially Expressed Cytokines of Cerebrospinal Fluid to Predict the Progression of Hand, Foot and Mouth Disease

  2021cites this paper
• Longitudinal in vivo imaging of acute neuropathology in a monkey model of Ebola virus infection

  2021cites this paper
• Epidemiological characteristics and cerebrospinal fluid cytokine profiles of enterovirus encephalitis in children in Hangzhou, China

  2021cites this paper
• TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection

  2020cites this paper
• Global Spread of the B5 Subgenotype EV-A71 and the Phylogeographical Analysis of Chinese Migration Events

  2020cites this paper
• Predicting Severe Enterovirus 71-Infected Hand, Foot, and Mouth Disease: Cytokines and Chemokines

  2020cites this paper
• TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection

  2019cites this paper
• Immune responses against enterovirus A71 infection: Implications for vaccine success

  2019cites this paper
• 1 Enterovirus 71 Represses Interleukin Enhancer 2 Binding Factor 2 Production and Nucleus 3 Translocation to Antagonize ILF 2 Antiviral Effects 4

  2019cites this paper
• Acute encephalitis in immunocompetent adults.

  2019cites this paper
• Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis

  2019cites this paper
• Enterovirus 71 Represses Interleukin Enhancer-Binding Factor 2 Production and Nucleus Translocation to Antagonize ILF2 Antiviral Effects

  2019cites this paper
• Global cytokine/chemokine profile identifies potential progression prediction indicators in hand-foot-and-mouth disease patients with Enterovirus A71 infections.

  2019cites this paper
• Acute Cardiac Complications in Critical Brain Disease.

  2018cites this paper
• USP4 positively regulates RLR-induced NF-κB activation by targeting TRAF6 for K48-linked deubiquitination and inhibits enterovirus 71 replication

  2018cites this paper
• Comparison of Cerebrospinal Fluid Cytokine Levels in Children of Enteroviral Meningitis With Versus Without Pleocytosis

  2018cites this paper
• Pyroptosis induced by enterovirus A71 infection in cultured human neuroblastoma cells.

  2018cites this paper
• Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response

  2018cites this paper
• Differences in the Levels of Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1ra) in Children with Status Epilepticus and Febrile Seizure

  2017cites this paper
• Acute Cardiac Complications in Critical Brain Disease.

  2017cites this paper
• Immunopathogenesis and Virus–Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease

  2017cites this paper
• HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress

  2017cites this paper
• Dynamic Interaction of Enterovirus 71 and Dendritic Cells in Infected Neonatal Rhesus Macaques

  2017cites this paper
• EV71 3D Protein Binds with NLRP3 and Enhances the Assembly of Inflammasome Complex

  2017cites this paper
• Neurotropism In Vitro and Mouse Models of Severe and Mild Infection with Clinical Strains of Enterovirus 71

  2017cites this paper
• Comparative Analysis of Serum Proteins from Patients with Severe and Mild EV‐A71‐induced HFMD using iTRAQ‐Coupled LC‐MS/MS Screening

  2017cites this paper
• Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells

  2017cites this paper
• Children as Biomarker Orphans: Progress in the Field of Pediatric Biomarkers.

  2017cites this paper
• HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection

  2017cites this paper
• Cardiac Complications in Patients Admitted to the Neuro-Intensive Care Unit

  2017cites this paper
• Plasma Cytokines and Chemokines in Zambian Children With Measles: Innate Responses and Association With HIV-1 Coinfection and In-Hospital Mortality

  2017cites this paper
• Cardiac disease in brain-heart disorders

  2016cites this paper
• CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF☆

  2016cites this paper
• Cytokines in cerebrospinal fluid of neurosyphilis patients: Identification of Urokinase plasminogen activator using antibody microarrays.

  2016cites this paper
• Motor coordination and balance measurements reveal differential pathogenicity of currently spreading enterovirus 71 strains in human SCARB2 transgenic mice.

  2016cites this paper
• Cardiac disease in brain-heart disorders.

  2016cites this paper
• Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology

  2016influential citation
• The Interleukin-1 Balance During Encephalitis Is Associated With Clinical Severity, Blood-Brain Barrier Permeability, Neuroimaging Changes, and Disease Outcome.

  2016cites this paper
• Cardiac Dysfunction After Neurologic Injury: What Do We Know and Where Are We Going?

  2016cites this paper
• A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease

  2016cites this paper
• Seroepidemiology and characterisation of neutralisation escape mutants of enterovirus A71 / Nik Nadia Nik Mohd Nasir

  2016influential citation
• The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model

  2015cites this paper
• Enterovirus Encephalitis Increases the Risk of Attention Deficit Hyperactivity Disorder

  2015cites this paper
• Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome.

  2015cites this paper
• Association Between Angiopoietin-2 and Enterovirus 71 Induced Pulmonary Edema

  2015cites this paper
• Elevated cerebrospinal fluid endothelin 1 associated with neurogenic pulmonary edema in children with enterovirus 71 encephalitis.

  2015cites this paper
• Increased Levels of Cytokines in Cerebrospinal Fluid of Children with Aseptic Meningitis Caused by Mumps Virus and Echovirus 30

  2014cites this paper
• Association analysis of polymorphisms in OAS1 with susceptibility and severity of hand, foot and mouth disease

  2014cites this paper
• Enterovirus 71 Brainstem Encephalitis Presenting with Pulmonary Hemorrhage and Acute Heart Failure

  2014cites this paper
• CNS-disease affecting the heart: brain-heart disorders.

  2014influential citation
• Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus infected children.

  2014cites this paper
• Interleukin-8 is elevated in severe hand, foot, and mouth disease.

  2014cites this paper
• The absence of exanthema is related with death and illness severity in acute enterovirus infection.

  2014cites this paper
• Study on Risk Factors for Severe Hand, Foot and Mouth Disease in China

  2014cites this paper
• Mediators of neutrophil function in children with protracted bacterial bronchitis.

  2014cites this paper
• Update of enterovirus 71 infection: epidemiology, pathogenesis and vaccine

  2014cites this paper
• Enteroviruses: Enterovirus 71

  2014cites this paper
• Implications of Age-Dependent Immune Responses to Enterovirus 71 Infection for Disease Pathogenesis and Vaccine Design.

  2013influential citation
• The Cytokine and Chemokine Profiles in Patients with Hand, Foot and Mouth Disease of Different Severities in Shanghai, China, 2010

  2013cites this paper