Direct detection of endogenous hydroxyl radical production in cultured adult cardiomyocytes during anoxia and reoxygenation. Is the hydroxyl radical really the most damaging radical species?

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Circulation Research

• Publication date

  1993-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1161/01.RES.72.4.725PMID 8383013
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Errata and corrigenda

  2024cited by this paper
• Identification of free radicals in myocardial ischemia/reperfusion by spin trapping with nitrone DMPO

  1992cited by this paper
• Quantification of hydroxyl radical and its lack of relevance to myocardial injury during early reperfusion after graded ischemia in rat hearts.

  1992cited by this paper
• Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly(ADP-ribose)polymerase.

  1991cited by this paper
• Production of singlet oxygen-derived hydroxyl radical adducts during merocyanine-540-mediated photosensitization: analysis by ESR-spin trapping and HPLC with electrochemical detection.

  1991cited by this paper
• Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes.

  1991cited by this paper
• Detection of hydroxyl radicals in the post-ischemic reperfused heart using salicylate as a trapping agent.

  1991cited by this paper
• Treatment With Deferoxamine During Ischemia Improves Functional and Metabolic Recovery and Reduces Reperfusion‐Induced Oxygen Radical Generation in Rabbit Hearts

  1991cited by this paper
• Cellular glutathione and the response of adult rat heart myocytes to oxidant stress.

  1990cited by this paper
• Iron-mediated radical reactions upon reperfusion contribute to myocardial "stunning".

  1990cited by this paper
• Ultrastructural effects of lipid peroxidation on the cardiac sarcolemma of the isolated rat heart

  1990cited by this paper
• Inability of desferrioxamine to limit tissue injury in the ischaemic and reperfused rabbit heart.

  1989cited by this paper
• Flow cytometric analysis of oxidative product formation in phytohemagglutinin-stimulated ethanol-treated immune mononuclear cells.

  1989cited by this paper
• Evaluation of human monocyte oxidative metabolism utilizing a flow cytometric assay.

  1989cited by this paper
• Cytosolic ionized calcium and bleb formation after acute cell injury of cultured rabbit renal tubule cells.

  1989cited by this paper
• Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.

  1989cited by this paper
• Spin-trapping and human neutrophils. Limits of detection of hydroxyl radical.

  1989cited by this paper
• Measurement and characterization of postischemic free radical generation in the isolated perfused heart.

  1989cited by this paper
• Dimethylthiourea, but not dimethylsulfoxide, reduces canine myocardial infarct size.

  1989cited by this paper
• Early treatment with deferoxamine limits myocardial ischemic/reperfusion injury.

  1989cited by this paper
• Mechanisms of reoxygenation-induced calcium overload in cultured chick embryo heart cells.

  1988cited by this paper
• Evidence For a Role of Iron‐Catalyzed Oxidants in Functional and Metabolic Stunning in the Canine Heart

  1988cited by this paper
• Myocardial dysfunction and ultrastructural alterations mediated by oxygen metabolites.

  1988cited by this paper
• Toxic consequence of the abrupt depletion of glutathione in cultured rat hepatocytes.

  1988cited by this paper
• Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

  1988cited by this paper
• Is superoxide demonstration by electron-spin resonance spectroscopy really superoxide?

  1988cited by this paper
• Irreversible injury of isolated adult rat myocytes. Osmotic fragility during metabolic inhibition.

  1988cited by this paper
• Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

  1988cited by this paper
• Free radicals and myocardial ischemia and reperfusion injury.

  1987cited by this paper
• Direct measurement of free radical generation following reperfusion of ischemic myocardium.

  1987cited by this paper
• Superoxide dismutase protects cultured neurons against death by starvation.

  1987cited by this paper
• Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes

  1987cited by this paper
• The formation of plasma membrane blebs in hepatocytes exposed to agents that increase cytosolic Ca2+ is mediated by the activation of a non‐lysosomal proteolytic system

  1986cited by this paper
• O2 free radical-mediated myocardial and vascular dysfunction.

  1986cited by this paper
• Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts.

  1986cited by this paper
• The oxygen free radical system: a fundamental mechanism in the production of myocardial necrosis.

  1986cited by this paper
• Oxygen-derived free radicals in postischemic tissue injury.

  1985cited by this paper
• Myocardial alterations due to free-radical generation.

  1984cited by this paper
• Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products.

  1984cited by this paper
• The mechanism of mannitol in reducing ischemic injury: hyperosmolarity or hydroxyl scavenger?

  1984cited by this paper
• Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury.

  1984cited by this paper
• Mechanisms of the killing of cultured hepatocytes by hydrogen peroxide.

  1984cited by this paper
• Isolation of calcium tolerant myocytes from adult rat hearts: review of the literature and description of a method.

  1983cited by this paper
• Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

  1983cited by this paper
• Biology of disease: free radicals and tissue injury.

  1982cited by this paper
• An investigation into the role of hydroxyl radical in xanthine oxidase-dependent lipid peroxidation.

  1982cited by this paper
• Reactions of ferrioxamine and desferrioxamine with the hydroxyl radical.

  1982cited by this paper
• Culturing of calcium stable adult cardiac myocytes.

  1982cited by this paper
• Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates

  1978cited by this paper
• A rapid technique for the isolation and purification of adult cardiac muscle cells having respiratory control and a tolerance to calcium.

  1976cited by this paper

• Cardioprotective Activity of Cassia fistula L. Bark Extract in Isoproterenol-Induced Myocardial Infarction Rat Model

  2022cites this paper
• A Commentary on the Effect of Targeted Temperature Management in Patients Resuscitated from Cardiac Arrest

  2022cites this paper
• Upregulation of hemeoxygenase enzymes HO-1 and HO-2 following ischemia-reperfusion injury in connection with experimental cardiac arrest and cardiopulmonary resuscitation: Neuroprotective effects of methylene blue.

  2021cites this paper
• Progress in Pathophysiological Mechanism of Global Cerebral Ischemia-Reperfusion Injury

  2020cites this paper
• Research on the hepatotoxicity mechanism of citrate-modified silver nanoparticles based on metabolomics and proteomics

  2018cites this paper
• Subdural hematoma decompression model: A model of traumatic brain injury with ischemic‐reperfusional pathophysiology: A review of the literature

  2018cites this paper
• Plasma metabolic profiling analysis of Strychnos nux-vomica Linn. and Tripterygium wilfordii Hook F-induced renal toxicity using metabolomics coupled with UPLC/Q-TOF-MS.

  2018cites this paper
• A Novel Method for Evaluating the Cardiotoxicity of Traditional Chinese Medicine Compatibility by Using Support Vector Machine Model Combined with Metabonomics

  2016cites this paper
• Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus.

  2016cites this paper
• Targeted temperature management in traumatic brain injury

  2016cites this paper
• Research on the Relationships between Endogenous Biomarkers and Exogenous Toxic Substances of Acute Toxicity in Radix Aconiti

  2016cites this paper
• Plasma metabolic profiling analysis of cyclophosphamide-induced cardiotoxicity using metabolomics coupled with UPLC/Q-TOF-MS and ROC curve.

  2016cites this paper
• mRNA Variants of a Neuronal Sodium Channel in Rat Cardiac Myocytes

  2015cites this paper
• Screening, verification, and optimization of biomarkers for early prediction of cardiotoxicity based on metabolomics.

  2015cites this paper
• Selected oxidative stress markers in gynecological laparoscopy

  2014cites this paper
• Paradoxical action of reactive oxygen species in creation and therapy of cancer.

  2014cites this paper
• Oxidative stress and myocardial injury in the diabetic heart

  2013cites this paper
• Preconditioning for Traumatic Brain Injury

  2013cites this paper
• The metabolic disturbances of isoproterenol induced myocardial infarction in rats based on a tissue targeted metabonomics.

  2013cites this paper
• Preoperative-induced mild hypothermia attenuates neuronal damage in a rat subdural hematoma model.

  2013cites this paper
• Neuroprotective effect of preoperatively induced mild hypothermia as determined by biomarkers and histopathological estimation in a rat subdural hematoma decompression model.

  2013cites this paper
• Oxidation of Selected Lipids in Low Density Lipoprotein: Effects on Calcium Transients in Isolated Rabbit Cardiomyocytes

  2013cites this paper
• Cardioprotective and antilipidemic effect of gemmo therapeutically treated Glycyrrhiza glabra against isoproterenol induced myocardial injury.

  2013cites this paper
• Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats.

  2012cites this paper
• Oxidative stress and the diabetic heart 233 Oxidative stress and myocardial ischaemia – reperfusion injury

  2012cites this paper
• Obstructive Sleep Apnea Severity Correlates with Cellular and Plasma Oxidative Stress Parameters and Affective Symptoms

  2012cites this paper
• Efeito do extracto de folhas de Ginkgo biloba em células HepG2 tratadas com Paraquato

  2012cites this paper
• Molecular Mechanism of Reperfusion Injury

  2012cites this paper
• Cardioprotective effect of Sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats.

  2011cites this paper
• State of the art in therapeutic hypothermia.

  2011cites this paper
• The Use of Hypothermia Therapy in Traumatic Ischemic/Reperfusional Brain Injury: Review of the Literatures

  2011cites this paper
• Intermittent hypobaric hypoxia improves postischemic recovery of myocardial contractile function via redox signaling during early reperfusion.

  2011cites this paper
• CARDIOPROTECTIVE PROPERTIES OF PYRAZOLO"E DERIVATIVES AGAI"ST ISOPROTERE"OL I"DUCED MYOCARDIAL ISCHEMIC I"JURY

  2010cites this paper
• Unique mode of cell death in freshly isolated adult rat ventricular cardiomyocytes exposed to hydrogen peroxide

  2009cites this paper
• [Obstructive sleep apnea contribution to oxidative stress in obesity].

  2008cites this paper
• Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes.

  2008cites this paper
• Myocardial Protection from Ischemia and Reperfusion Injury

  2008cites this paper
• Contribuição da Apnéia Obstrutiva do Sono para o Estresse Oxidativo da Obesidade artigo original

  2008cites this paper
• A triterpene saponin from Tribulus terrestris attenuates apoptosis in cardiocyte via activating PKC signalling transduction pathway

  2008cites this paper
• Cardioprotective Effect of Bacopa monneira Against Isoproterenol-Induced Myocardial Necrosis in Rats

  2007cites this paper
• CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury.

  2007cites this paper
• Synchronous progression of calcium transient-dependent beating and sarcomere destruction in apoptotic adult cardiomyocytes.

  2006cites this paper
• Controversy of free radical hypothesis: reactive oxygen species--cause or consequence of tissue injury?

  2005cites this paper
• New concepts in reactive oxygen species and cardiovascular reperfusion physiology.

  2004cites this paper
• Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats.

  2004cites this paper
• 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.

  2003cites this paper
• Exercise and cardioprotection

  2002cites this paper
• Dynamic process of apoptosis in adult rat cardiomyocytes analyzed using 48-hour videomicroscopy and electron microscopy: beating and rate are associated with the apoptotic process.

  2001cites this paper
• A light stabilizer Tinuvin 770-induced toxic injury of adult rat cardiac myocytes.

  2001cites this paper
• Apoptosis, rather than oncosis, is the predominant mode of spontaneous death of isolated adult rat cardiac myocytes in culture.

  2001cites this paper
• Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins.

  2001cites this paper
• Simvastatin inhibits noradrenaline‐induced hypertrophy of cultured neonatal rat cardiomyocytes

  2001cites this paper
• Melatonin protects against ischaemic-reperfusion myocardial damage.

  2001cites this paper
• Increased endogenous ascorbyl free radical formation with singlet oxygen scavengers in reperfusion injury: an EPR and functional recovery study in rat hearts.

  2000cites this paper
• Localization of dichlorofluorescin in cardiac myocytes: implications for assessment of oxidative stress.

  2000cites this paper
• The antioxidant effects of a novel iron chelator salicylaldehyde isonicotinoyl hydrazone in the prevention of H(2)O(2) injury in adult cardiomyocytes.

  2000cites this paper
• Reactive oxygen species contribute to the induction of superoxide dismutase during heat shock in cultured rat neonatal cardiomyocytes.

  2000cites this paper
• Determination of hydroxyl free radical formation in human platelets using high-performance liquid chromatography with electrochemical detection.

  1999cites this paper
• Different role of antioxidants in endotoxin-induced late myocardial protection.

  1999cites this paper
• Antiarrhythmic fatty acids and antioxidants in animal and cell studies.

  1999cites this paper
• Antioxidant status following acute ischemic limb injury: a rabbit model.

  1999cites this paper
• Prevention of reoxygenation injury by sodium salicylate in isolated-perfused rat liver.

  1998cites this paper
• Bcl-2 overexpression in the HaCaT cell line is associated with a different membrane fatty acid composition and sensitivity to oxidative stress.

  1998cites this paper
• Nitric oxide protects cardiomyocytes against tert-butyl hydroperoxide-induced formation of alkoxyl and peroxyl radicals and peroxidation of phosphatidylserine.

  1998cites this paper
• Susceptibility of LDL to oxidative stress in obstructive sleep apnea.

  1998cites this paper
• Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and then reoxygenated.

  1997cites this paper
• DNA synthesis in adult feline ventricular myocytes. Comparison of hypoxic and normoxic states.

  1996cites this paper
• Selective effects of oxygen free radicals on excitation-contraction coupling in ventricular muscle. Implications for the mechanism of stunned myocardium.

  1996cites this paper
• Peroxynitrite-induced cardiac myocyte injury.

  1996cites this paper
• Menadione‐Induced Oxidative Stress in Bovine Heart Microvascular Endothelial Cells a

  1996cites this paper
• Creatine kinase is the main target of reactive oxygen species in cardiac myofibrils.

  1996cites this paper
• Reperfusion injury on cardiac myocytes after simulated ischemia.

  1996cites this paper
• Direct evidence that initial oxidative stress triggered by preconditioning contributes to second window of protection by endogenous antioxidant enzyme in myocytes.

  1996cites this paper
• Late Ischemic Preconditioning Is Mediated in Myocytes by Enhanced Endogenous Antioxidant Activity Stimulated by Oxygen‐Derived Free Radicals a

  1996cites this paper
• High D-Glucose–Induced Changes in Endothelial Ca2+/EDRF Signaling are Due to Generation of Superoxide Anions

  1996cites this paper
• K-7259, a novel dilazep derivative, and d-propranolol attenuate H2O2-induced cell damage.

  1996cites this paper
• Protection of reoxygenated cardiomyocytes against osmotic fragility by nitric oxide donors.

  1996cites this paper
• Phospholipid hydroperoxides are precursors of lipid alkoxyl radicals produced from anoxia/reoxygenated endothelial cells.

  1995cites this paper
• [Inactivation of the myocardial lipoamide dehydrogenase by catecholamines. Prevention by captopril and other thiol compounds].

  1995cites this paper
• Effects of N-acetylcysteine in the rat heart reperfused after low-flow ischemia: evidence for a direct scavenging of hydroxyl radicals and a nitric oxide-dependent increase in coronary flow.

  1995cites this paper
• Is free radical generation an important component of ischemia/reperfusion injury? Part 2.

  1995cites this paper
• Ischemia- and reperfusion-sensitive cardiac sympathetic afferents: influence of H2O2 and hydroxyl radicals.

  1995cites this paper
• Effects of doxorubicin on cardiomyocytes with reduced level of superoxide dismutase.

  1995cites this paper
• Hydroxylation of aromatic compounds as indices of hydroxyl radical production: a cautionary note revisited.

  1995cites this paper
• Gallium chloride effects on neonatal rat heart cells in culture, in standard and oxidative conditions

  1994cites this paper
• Cytoskeletal alterations in cultured cardiomyocytes following exposure to the lipid peroxidation product, 4-hydroxynonenal.

  1994cites this paper
• Cerebral vasospasm and free radicals.

  1994cites this paper
• Inhibition of vasoactive amine induced contractions of vascular smooth muscle by hydrogen peroxide in rabbit aorta.

  1994cites this paper
• Salicylate trapping of .OH as a tool for studying post-ischemic oxidative injury in the isolated rat heart.

  1994cites this paper
• Ionic basis of ischaemic cardiac injury: insights from cellular studies.

  1994cites this paper
• Hydrogen peroxide cytotoxicity in cultured cardiac myocytes is iron dependent.

  1994cites this paper
• Free radicals and the heart.

  1993cites this paper