Parallel signaling pathways regulate excitable dynamics differently to mediate pseudopod formation during eukaryotic chemotaxis

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Journal of Cell Science

• Publication date

  2018-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.214775PMID 30404836
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Excitable Signal Transduction Networks in Directed Cell Migration.

  2017influential reference
• University of Groningen Characterization of two unusual guanylyl cyclases from Dictyostelium

  2017cited by this paper
• Elements of biological oscillations in time and space

  2016cited by this paper
• Leading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration.

  2016cited by this paper
• The front and rear of collective cell migration

  2016cited by this paper
• Heterotrimeric G-protein shuttling via Gip1 extends the dynamic range of eukaryotic chemotaxis

  2016cited by this paper
• Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes

  2014cited by this paper
• Evolutionarily Conserved Coupling of Adaptive and Excitable Networks Mediates Eukaryotic Chemotaxis

  2014cited by this paper
• Excitable signal transduction induces both spontaneous and directional cell asymmetries in the phosphatidylinositol lipid signaling system for eukaryotic chemotaxis.

  2014cited by this paper
• Intracellular encoding of spatiotemporal guidance cues in a self-organizing signaling system for chemotaxis in Dictyostelium cells.

  2013cited by this paper
• An Excitable Signal Integrator Couples to an Idling Cytoskeletal Oscillator to Drive Cell Migration

  2013influential reference
• A Continuum Model of Actin Waves in Dictyostelium discoideum

  2013cited by this paper
• PIP3 waves and PTEN dynamics in the emergence of cell polarity.

  2012cited by this paper
• Different modes of state transitions determine pattern in the Phosphatidylinositide-Actin system

  2011cited by this paper
• Moving in the right direction: how eukaryotic cells migrate along chemical gradients.

  2011cited by this paper
• Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

  2011cited by this paper
• Self-organization of the phosphatidylinositol lipids signaling system for random cell migration

  2010cited by this paper
• Cells navigate with a local-excitation, global-inhibition-biased excitable network

  2010cited by this paper
• Navigation of Chemotactic Cells by Parallel Signaling to Pseudopod Persistence and Orientation

  2009cited by this paper
• Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling

  2009cited by this paper
• How a Cell Crawls and the Role of Cortical Myosin II

  2009cited by this paper
• Intramolecular Activation Mechanism of the Dictyostelium LRRK2 Homolog Roco Protein GbpC*

  2008cited by this paper
• PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis.

  2008cited by this paper
• The role of cGMP and the rear of the cell in Dictyostelium chemotaxis and cell streaming

  2008cited by this paper
• Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum

  2008cited by this paper
• Actin-based propulsive forces and myosin-II-based contractile forces in migrating Dictyostelium cells

  2008cited by this paper
• Correlated waves of actin filaments and PIP3 in Dictyostelium cells.

  2008influential reference
• Flow photolysis for spatiotemporal stimulation of single cells.

  2007cited by this paper
• Mutants in the Dictyostelium Arp2/3 complex and chemoattractant-induced actin polymerization.

  2007cited by this paper
• Guanylyl cyclase protein and cGMP product independently control front and back of chemotaxing Dictyostelium cells.

  2006cited by this paper
• University of Groningen Characterization of the GbpD-activated Rap1 Pathway Regulating Adhesion and Cell Polarity in Dictyostelium discoideum Kortholt,

  2006cited by this paper
• Touch and go: guidance cues signal to the growth cone cytoskeleton.

  2005cited by this paper
• Developmental control of cAMP-induced Ca2+-influx by cGMP: influx is delayed and reduced in a cGMP-phosphodiesterase D deficient mutant of Dictyostelium discoideum.

  2005influential reference
• RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium

  2005influential reference
• Chemotaxis: signalling the way forward

  2004cited by this paper
• A brilliant monomeric red fluorescent protein to visualize cytoskeleton dynamics in Dictyostelium

  2004cited by this paper
• Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement

  2004cited by this paper
• Activation of soluble guanylyl cyclase at the leading edge during Dictyostelium chemotaxis.

  2004influential reference
• Identification of a novel type of cGMP phosphodiesterase that is defective in the chemotactic stmF mutants.

  2002cited by this paper
• A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium

  2002influential reference
• Identification of four candidate cGMP targets in Dictyostelium

  2002cited by this paper
• The Dictyostelium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase

  2001influential reference
• Polarization of chemoattractant receptor signaling during neutrophil chemotaxis.

  2000cited by this paper
• Chemoattractant‐mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

  1999influential reference
• Propagation of traveling waves in excitable media.

  1996cited by this paper
• Aberrant cGMP-binding activity in non-chemotactic Dictyostelium discoideum mutants.

  1995cited by this paper
• Non-chemotactic Dictyostelium discoideum mutants with altered cGMP signal transduction

  1993cited by this paper
• Excitation, adaption, and deadaptation of the cAMP-mediated cGMP Response in dictyostelium discoideum

  1983cited by this paper
• Nonequilibrium kinetics of a cyclic GMP-binding protein in dictyostelium discoideum

  1982cited by this paper
• Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture.

  1970cited by this paper

• Spatial distribution of cytoskeleton-mediated feedback controls cell polarization: a computational study

  2025cites this paper
• Spatial distribution of cytoskeleton-mediated feedback controls cell polarization: A computational study

  2025cites this paper
• Excitable Ras dynamics-based screens reveal RasGEFX is required for macropinocytosis and random cell migration

  2025cites this paper
• Spontaneous signal generation by an excitable system for cell migration

  2024cites this paper
• Dynamics of intracellular cGMP during chemotaxis in Dictyostelium cells.

  2023cites this paper
• Sphingomyelin metabolism underlies Ras excitability for efficient cell migration and chemotaxis

  2023cites this paper
• RasGEFX triggers spontaneous Ras excitation with RasGEFB/M/U for random cell migration

  2023cites this paper
• Cleavage furrow positioning in dividing Dictyostelium cells

  2023cites this paper
• Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis

  2021cites this paper
• Different Heterotrimeric G Protein Dynamics for Wide-Range Chemotaxis in Eukaryotic Cells

  2021cites this paper
• Unified control of amoeboid pseudopod extension in multiple organisms by branched F-actin in the front and parallel F-actin/myosin in the cortex

  2020cites this paper
• Talin B regulates collective cell migration via PI3K signaling in Dictyostelium discoideum mounds.

  2020cites this paper
• Unified control of amoeboid pseudopod extension in multiple organisms by branched F-actin in the front and parallel F-actin/myosin in the cortex.

  2020cites this paper
• Plasticity of cell migration resulting from mechanochemical coupling

  2019cites this paper
• Wave patterns organize cellular protrusions and control cortical dynamics

  2019cites this paper
• Excitable dynamics of Ras triggers spontaneous symmetry breaking of PIP3 signaling in motile cells

  2019cites this paper