WWP2 Is One Promising Novel Oncogene

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Pathology and Oncology Research

• Publication date

  2018-11-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12253-018-0506-5PMID 30415470
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression of WW domain-containing protein 2 is correlated with pathological grade and recurrence of glioma.

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• Silencing of hypoxia-inducible factor-1α promotes thyroid cancer cell apoptosis and inhibits invasion by downregulating WWP2, WWP9, VEGF and VEGFR2.

  2016cited by this paper
• Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells

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• Silencing of WWP2 inhibits adhesion, invasion, and migration in liver cancer cells

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• WWP2 is required for normal cell cycle progression

  2015cited by this paper
• Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled

  2015cited by this paper
• WWP2 and its association with PTEN in endometrial cancer

  2015cited by this paper
• Paip1, an Effective Stimulator of Translation Initiation, Is Targeted by WWP2 for Ubiquitination and Degradation

  2014cited by this paper
• Wwp2 targets SRG3, a scaffold protein of the SWI/SNF-like BAF complex, for ubiquitination and degradation.

  2014cited by this paper
• WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice

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• WWP2: A Multifunctional Ubiquitin Ligase Gene

  2014cited by this paper
• Notch3 Interactome Analysis Identified WWP2 as a Negative Regulator of Notch3 Signaling in Ovarian Cancer

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• WWP2 ubiquitin ligase and its isoforms: New biological insight and promising disease targets

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• WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells

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• Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

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• The HECT family of E3 ubiquitin ligases: multiple players in cancer development.

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• Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.

  2007cited by this paper
• Wwp2-Mediated Ubiquitination of the RNA Polymerase II Large Subunit in Mouse Embryonic Pluripotent Stem Cells

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• Wwp2, an E3 Ubiquitin Ligase That Targets Transcription Factor Oct-4 for Ubiquitination*

  2004cited by this paper
• Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel.

  2002cited by this paper
• Function of WW domains as phosphoserine- or phosphothreonine-binding modules.

  1999cited by this paper
• Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.

  1998cited by this paper
• Identification of Novel Human WW Domain-containing Proteins by Cloning of Ligand Targets*

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• WWP2 promotes the proliferation and metastasis of NSCLC through Hippo pathway and Wnt pathway

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• E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases.

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• The role of WWP1 and WWP2 in bone/cartilage development and diseases

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• Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression

  2023cites this paper
• WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein

  2023cites this paper
• WWP1 E3 ligase at the crossroads of health and disease

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• WWP2 binds to NKRF, enhances the NF-κB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells.

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• Apigenin promotes cell death in NCI-H23 cells by upregulation of PTEN: potential involvement of the binding of apigenin with WWP2 protein

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• Orchestration of a blood-derived and ADARB1-centred network in Alzheimer's and Parkinson's disease.

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• The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia

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• Genes of the Ubiquitin Proteasome System Qualify as Differential Markers in Malignant Glioma of Astrocytic and Oligodendroglial Origin

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• WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway

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• The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response

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• Potential of E3 Ubiquitin Ligases in Cancer Immunity: Opportunities and Challenges

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• WW Domain-Containing E3 Ubiquitin Protein Ligase 1: A Self-Disciplined Oncoprotein

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• DKK1 Suppresses WWP2 to Enhance Bortezomib Resistance in Multiple Myeloma via Regulating GLI2 Ubiquitination.

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• The Role of HECT-Type E3 Ligase in the Development of Cardiac Disease

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• ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2

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• PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation

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• WWP2 regulates SIRT1‐STAT3 acetylation and phosphorylation involved in hypertensive angiopathy

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• The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

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• CPSF7 regulates liver cancer growth and metastasis by facilitating WWP2-FL and targeting the WWP2/PTEN/AKT signaling pathway.

  2019cites this paper
• Targeting E3 ubiquitin ligases to sensitize cancer radiation therapy

  2019cites this paper