Epidermal Darwinism and Competitive Equilibrium within the Epidermis.

In normal homeostasis, cancer defense, or stem cell therapy, epidermal progenitors undergo constant competition to reach an equilibrium state. In this issue of Cell Stem Cell, Mesa et al. (2018) and Murai et al. (2018) show that skin epidermal progenitors maintain tissue homeostasis through competitive equilibrium under physiological self-renewal or oncogenic conditions.

• Publication year

  2018

• Venue

  Cell Stem Cell

• Publication date

  2018-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.stem.2018.10.019PMID 30388416PMCID PMC7428142
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation.

  2018cited by this paper
• E-cadherin in Contact Inhibition and Cancer

  2018cited by this paper
• Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations

  2018cited by this paper
• Spatial constraints govern competition of mutant clones in human epidermis

  2017cited by this paper
• Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification

  2017cited by this paper
• Correction of aberrant growth preserves tissue homeostasis

  2017cited by this paper
• High burden and pervasive positive selection of somatic mutations in normal human skin

  2015cited by this paper
• β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche

  2014cited by this paper
• The river of stem cells.

  2009cited by this paper
• Neural Darwinism. The Theory of Neuronal Group Selection. Gerald M. Edelman. Basic Books, New York, 1987. xxii, 371 pp., illus. $29.95.

  1988cited by this paper
• Neural Darwinism: The Theory Of Neuronal Group Selection

  1987cited by this paper

• Energy competition remodels the metabolic glucose landscape of psoriatic epidermal cells

  2024cites this paper
• Theranostics

  2021cites this paper
• Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures

  2021cites this paper
• The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendages

  2021cites this paper
• A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Oesophagus

  2021cites this paper
• Its written all over your face: the molecular and physiological consequences of aging skin.

  2020cites this paper
• Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials

  2019cites this paper