Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly

Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued defective neuronal migration in Lis1+/− mice, impaired behavioral performance and improvement of 18F-FDG uptake. Furthermore, SNJ1945 improved the neural circuit formation and retrograde transport of NFG in Lis1+/− mice. Thus, SNJ1945 is a potential drug for the treatment of human lissencephaly patients.

• Publication year

  2013

• Venue

  Scientific Reports

• Publication date

  2013-02-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/srep01224PMID 23390575PMCID 3565454
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Elimination of inhibitory synapses is a major component of adult ocular dominance plasticity.

  2012cited by this paper
• Activation of Aurora-A Is Essential for Neuronal Migration via Modulation of Microtubule Organization

  2012cited by this paper
• Lis1 is an initiation factor for dynein-driven organelle transport

  2012cited by this paper
• Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction

  2012cited by this paper
• Establishment of In Vivo Brain Imaging Method in Conscious Mice

  2010cited by this paper
• A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice

  2010cited by this paper
• Inhibition of calpain increases LIS1(PAFAH1B1) and partially rescues in vivo phenotypes in a mouse model of lissencephaly

  2009cited by this paper
• Emotion circuits in the brain.

  2009cited by this paper
• LIS1 and NDEL1 coordinate the plus‐end‐directed transport of cytoplasmic dynein

  2008cited by this paper
• A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice.

  2008cited by this paper
• Dcx Re-expression Reduces Subcortical Band Heterotopia and Seizure Threshold in an Animal Model of Neuronal Migration Disorder

  2008cited by this paper
• Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division.

  2008cited by this paper
• Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders

  2008cited by this paper
• Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development

  2007cited by this paper
• In Vivo mouse imaging and spectroscopy in drug discovery

  2007cited by this paper
• One at a time, live tracking of NGF axonal transport using quantum dots

  2007cited by this paper
• Retinal Penetration of Calpain Inhibitors in Rats After Oral Administration

  2006cited by this paper
• Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester.

  2006cited by this paper
• Measuring calcium signaling using genetically targetable fluorescent indicators

  2006cited by this paper
• Complete Loss of Ndel1 Results in Neuronal Migration Defects and Early Embryonic Lethality

  2005cited by this paper
• Regulation of Gephyrin and GABAA Receptor Binding within the Amygdala after Fear Acquisition and Extinction

  2005cited by this paper
• New vistas on amygdala networks in conditioned fear.

  2004cited by this paper
• Role of the Amygdala in Fear Extinction Measured with Potentiated Startle

  2003cited by this paper
• Transcriptional Regulation of Cortical Neuron Migration by POU Domain Factors

  2002cited by this paper
• LIS1: cellular function of a disease-causing gene.

  2001cited by this paper
• Lissencephaly: Fetal pattern of glucose metabolism on positron emission tomography?

  2000cited by this paper
• Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice.

  1999cited by this paper
• Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality

  1998cited by this paper
• Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor

  1994cited by this paper
• Miller-Dicker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase

  1994cited by this paper
• Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats.

  1993cited by this paper

• Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders

  2024cites this paper
• Calpain-2 Inhibitors as Therapy for Traumatic Brain Injury

  2023cites this paper
• LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons

  2022cites this paper
• Novel Perspectives on the Development of the Amygdala in Rodents

  2021cites this paper
• Neuronal Cytoskeleton in Intellectual Disability: From Systems Biology and Modeling to Therapeutic Opportunities

  2021cites this paper
• Toward a Better Understanding of Neuronal Migration Deficits in Autism Spectrum Disorders

  2019cites this paper
• Delayed, oral pharmacological inhibition of calpains attenuates adverse post-infarction remodelling

  2017cites this paper
• Postnatal calpain inhibition elicits cerebellar cell death and motor dysfunction

  2017cites this paper
• Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning

  2017influential citation
• Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders

  2017cites this paper
• Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT.

  2017cites this paper
• Calpain research for drug discovery: challenges and potential

  2016cites this paper
• Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition*

  2016cites this paper
• Neuroprotection mediated by inhibition of calpain during acute viral encephalitis

  2016cites this paper
• Genetic Causes of Intellectual Disability: The Genes Controlling Cortical Development

  2016cites this paper
• Genes and brain malformations associated with abnormal neuron positioning

  2015cites this paper
• Erythropoietin Modulates Cerebral and Serum Degradation Products from Excess Calpain Activation following Prenatal Hypoxia-Ischemia

  2015cites this paper
• Effects of a novel orally administered calpain inhibitor SNJ‐1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis

  2014cites this paper
• Learning and memory: an emergent property of cell motility.

  2013cites this paper