[Alteration of left ventricular longitudinal systolic function in 2D-strain in primary aldosteronism: A new target organ damage marker].

OBJECTIVE Primary hyperaldosteronism is the leading cause of secondary hypertension, and leads to frequent cardiovascular complications. Many studies have studied left ventricular geometry and function in this population, but longitudinal systolic function is still poorly described. METHODS We studied 35 hypertensive patients with primary aldosteronism, and 35 with essential hypertension matched for age, sex, body mass index, and 24h blood pressure. Patients benefited from an echocardiography to measure the mass and the geometry of the left ventricle, left ventricle ejection fraction, systolic longitudinal, circumferential, and radial strain, and diastolic function. RESULTS Compared to essential hypertensive patients, patients with primary aldosteronism presented a significantly higher left ventricular mass index and relative wall thickness (60.3±16.1g/m2 vs 47.3±18.6, P=0.003, and 0.44±0.08 vs 0.36±0.06, P=0.00005, respectively), as well as a significantly reduced longitudinal systolic strain (-17.8±3,4 vs -20.3±3,6%, P=0.004). There were no significant differences in the other parameters. CONCLUSIONS Primary aldosteronism is associated with a deterioration of longitudinal systolic function of the left ventricle compared with essential hypertensive patients. This marker of cardiac damage, reproducible and easily available in routine could help for the screening of these patients.

• Publication year

  2018

• Venue

  Annales de cardiologie et d'angeiologie

• Publication date

  2018-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.ancard.2018.08.007PMID 30327134
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aldosterone induces left ventricular subclinical systolic dysfunction: a strain imaging study

  2018cited by this paper
• Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.

  2018cited by this paper
• Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice.

  2017cited by this paper
• Diagnostic rate of primary aldosteronism in Emilia-Romagna, Northern Italy, during 16 years (2000–2015)

  2017cited by this paper
• SFE/SFHTA/AFCE consensus on primary aldosteronism, part 1: Epidemiology of PA, who should be screened for sporadic PA?

  2016cited by this paper
• Progress in aldosteronism: a review of the prevalence of primary aldosteronism in pre-hypertension and hypertension.

  2015cited by this paper
• Prognostic value of left ventricular mass normalized to different body size indexes: findings from the PAMELA population

  2015cited by this paper
• Prognostic Importance of Impaired Systolic Function in Heart Failure With Preserved Ejection Fraction and the Impact of Spironolactone

  2015cited by this paper
• Cardiovascular Complications Associated With Primary Aldosteronism: A Controlled Cross-Sectional Study

  2013cited by this paper
• Left Heart Morphology and Function in Primary Aldosteronism

  2012cited by this paper
• Demonstration of Blood Pressure-Independent Noninfarct Myocardial Fibrosis in Primary Aldosteronism: A Cardiac Magnetic Resonance Imaging Study

  2012cited by this paper
• Prognostic value of the extent of left ventricular hypertrophy and its evolution in the hypertensive patient

  2012cited by this paper
• Cardiac dimensions are largely determined by dietary salt in patients with primary aldosteronism: results of a case-control study.

  2011cited by this paper
• Salt and aldosterone: a concert of bad effects.

  2010cited by this paper
• Longitudinal strain and torsion assessed by two-dimensional speckle tracking correlate with the serum level of tissue inhibitor of matrix metalloproteinase-1, a marker of myocardial fibrosis, in patients with hypertension.

  2008cited by this paper
• Inappropriate Left Ventricular Mass Changes During Treatment Adversely Affects Cardiovascular Prognosis in Hypertensive Patients

  2007cited by this paper
• Role of aldosterone in left ventricular hypertrophy in hypertension.

  2006cited by this paper
• Chronic hyperaldosteronism in a transgenic mouse model fails to induce cardiac remodeling and fibrosis under a normal-salt diet.

  2004cited by this paper
• Aldosterone-induced organ damage: plasma aldosterone level and inappropriate salt status.

  2004cited by this paper
• Echocardiographic comparison of left ventricular structure and function in hypertensive patients with primary aldosteronism and essential hypertension.

  2002cited by this paper
• Prognosis of Inappropriate Left Ventricular Mass in Hypertension: The MAVI Study

  2002cited by this paper
• Left ventricular hypertrophy precedes other target-organ damage in primary aldosteronism.

  1997cited by this paper
• Left ventricular hypertrophy is more prominent in patients with primary aldosteronism than in patients with other types of secondary hypertension.

  1997cited by this paper
• Changes in left ventricular anatomy and function in hypertension and primary aldosteronism.

  1996cited by this paper
• Adverse prognostic significance of concentric remodeling of the left ventricle in hypertensive patients with normal left ventricular mass.

  1995cited by this paper
• Echocardiographic Determination of Left Ventricular Mass in Man: Anatomic Validation of the Method

  1977cited by this paper

• Aldosterone Effect on Cardiac Structure and Function

  2024cites this paper
• CMR-Verified Myocardial Fibrosis Is Associated With Subclinical Diastolic Dysfunction in Primary Aldosteronism Patients

  2021cites this paper
• Left ventricular global longitudinal strain in secondary hypertension: A meta-analysis of echocardiographic studies.

  2021cites this paper
• Left ventricular remodeling and dysfunction in primary aldosteronism

  2020cites this paper