Antioxidant status in breast cancer patients of different ages after radiotherapy

In this study we investigated the effects of breast cancer radiotherapy on the antioxidant (AO) enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), as well as on the concentration of reduced glutathione (GSH) and lipid peroxides (LP) in blood of patients aged 45-58 years and older than 60 years. The results show that in blood of patients aged 45-58 years, radiotherapy increased the activities of CuZnSOD, CAT, and GR, as well as the concentration of GSH, without affecting the activity of GPx and concentration of LP. In patients older than 60 years, radiotherapy increased the activities of CuZnSOD and CAT, lowered the activity of GPx and concentration of GSH, and increased the concentration of LP. Our results indicate that the response to radiotherapy involves age-related impairment of AO capacity for elimination of H2O2, causing oxidative damage to blood cells. This suggests that cytotoxic effects of radiation on healthy tissues might be more pronounced during the aging of breast cancer patients, and should be considered in the further development of individualization protocols in cancer radiotherapy.

• Publication year

  2009

• Venue

  Archives of Biological Sciences

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.2298/ABS0901023K
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008cited by this paper
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  2006cited by this paper
• Increased expression of antioxidant enzymes in radioresistant variant from U251 human glioblastoma cell line.

  2004cited by this paper
• The role of glutathione in cancer

  2004cited by this paper
• Role of superoxide dismutase in individualization of breast cancer radiation therapy protocols

  2003cited by this paper
• Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research.

  2003influential reference
• Correlation between antioxidant status, tumorigenicity and radiosensitivity in sister rat cell lines.

  2002cited by this paper
• Oxidative stress, DNA damage, and breast cancer.

  2002cited by this paper
• Radioprotectors in radiotherapy.

  2001cited by this paper
• Glutathione and its metabolizing enzymes in patients with different benign and malignant diseases.

  2000cited by this paper
• Role of antioxidant enzymes in radiosensitivity of human blood cells.

  2000influential reference
• Oxidants and Antioxidants in Breast Cancer

  2000influential reference
• Chromosome aberrations, micronuclei, and activity of superoxide dismutases in human lymphocytes after irradiation in vitro

  2000cited by this paper
• [Oxidative stress and aging].

  1997cited by this paper
• Oxidative mechanisms in the toxicity of metal ions.

  1995cited by this paper
• Fatty acid-mediated effects on the glutathione redox cycle in cultured endothelial cells.

  1994cited by this paper
• Production of large amounts of hydrogen peroxide by human tumor cells.

  1991cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951influential reference

• The Biological Process of Aging and the Impact of Ionizing Radiation.

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  2014cites this paper
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  2010influential citation