Sepiapterin Ameliorates Chemically Induced Murine Colitis and Azoxymethane-Induced Colon Cancer

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2013-10-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1124/jpet.113.203828PMID 23912334PMCID PMC3781406
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interleukin-6 - A Key Regulator of Colorectal Cancer Development

  2012influential reference
• A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice

  2012cited by this paper
• Recommendations for the use of sapropterin in phenylketonuria.

  2012cited by this paper
• Tetrahydrobiopterin Protects Soluble Guanylate Cyclase against Oxidative Inactivation

  2012cited by this paper
• A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice.

  2012cited by this paper
• Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation

  2012cited by this paper
• Interleukin 37 expression protects mice from colitis

  2011cited by this paper
• Safety of extended treatment with sapropterin dihydrochloride in patients with phenylketonuria: results of a phase 3b study.

  2011cited by this paper
• Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction.

  2011cited by this paper
• Inhibition of Striatal Soluble Guanylyl Cyclase-cGMP Signaling Reverses Basal Ganglia Dysfunction and Akinesia in Experimental Parkinsonism

  2011cited by this paper
• Nitric oxide and oxidative stress in vascular disease

  2010cited by this paper
• Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.

  2010cited by this paper
• The effect of tyrosine nitration of L‐type Ca2+ channels on excitation–transcription coupling in colonic inflammation

  2010cited by this paper
• Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation.

  2010cited by this paper
• Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis

  2010influential reference
• Oral nitrite ameliorates dextran sulfate sodium-induced acute experimental colitis in mice.

  2010cited by this paper
• PKG inhibits TCF signaling in colon cancer cells by blocking β-catenin expression and activating FOXO4

  2010cited by this paper
• NO generation from inorganic nitrate and nitrite: Role in physiology, nutrition and therapeutics

  2009cited by this paper
• Macrophage-derived IL-1β stimulates Wnt signaling and growth of colon cancer cells; a crosstalk interrupted by vitamin D3

  2009influential reference
• Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis.

  2008cited by this paper
• NF‐κB in inflammatory bowel disease

  2008cited by this paper
• Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1.

  2008cited by this paper
• Tyrosine nitration of IkappaBalpha: a novel mechanism for NF-kappaB activation.

  2007cited by this paper
• Nitrotyrosylation of Ca2+ Channels Prevents c-Src Kinase Regulation of Colonic Smooth Muscle Contractility in Experimental Colitis

  2007cited by this paper
• A lipophilic statin, pitavastatin, suppresses inflammation‐associated mouse colon carcinogenesis

  2007cited by this paper
• Colorectal carcinoma development in inducible nitric oxide synthase‐deficient mice with dextran sulfate sodium‐induced ulcerative colitis

  2007cited by this paper
• An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression

  2007cited by this paper
• Tyrosine nitration of IκBα : A novel mechanism for NF-κB activation

  2007cited by this paper
• Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

  2005cited by this paper
• Reversal of experimental colitis disease activity in mice following administration of an adenoviral IL-10 vector

  2005cited by this paper
• Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells.

  2005cited by this paper
• S-nitrosylation: Physiological regulation of NF-κB

  2004cited by this paper
• Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation.

  2004cited by this paper
• S-nitrosylation: physiological regulation of NF-kappaB.

  2004cited by this paper
• Regulation of Endothelial Nitric Oxide Synthase by Tetrahydrobiopterin in Vascular Disease

  2004cited by this paper
• Tetrahydrobiopterin uptake in supplemental administration: elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive process.

  2004cited by this paper
• Dextran sodium sulfate-induced colitis reveals nicotinic modulation of ion transport via iNOS-derived NO.

  2004cited by this paper
• Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment.

  2003cited by this paper
• Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms

  2003cited by this paper
• Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db−/−) mice: role of decreased tetrahydrobiopterin bioavailability

  2002cited by this paper
• Inflammation and cancer: back to Virchow?

  2001cited by this paper
• Oxygen Reduction by Nitric-oxide Synthases*

  2001cited by this paper
• The role of nitric oxide chemistry in cancer treatment.

  1998cited by this paper
• Chromatographic analysis of pteridines.

  1980cited by this paper
• [55] Chromatographic analysis of pteridines

  1980cited by this paper

• Metabolomic Signatures Highlight Fiber-Degrading Bacteroides Species in Mediterranean Diet Response Among Ulcerative Colitis

  2024cites this paper
• Biopterin metabolism and nitric oxide recoupling in cancer

  2024cites this paper
• Uncoupled nitric oxide synthase activity promotes colorectal cancer progression

  2023cites this paper
• Molecular Imaging Investigations of Polymer-Coated Cerium Oxide Nanoparticles as a Radioprotective Therapeutic Candidate

  2023cites this paper
• Loss of Nitric Oxide Induces Fibrogenic Response in Organotypic 3D Co-Culture of Mammary Epithelia and Fibroblasts—An Indicator for Breast Carcinogenesis

  2021cites this paper
• The Role of the BH4 Cofactor in Nitric Oxide Synthase Activity and Cancer Progression: Two Sides of the Same Coin

  2021influential citation
• Metastatic Melanoma Progression Is Associated with Endothelial Nitric Oxide Synthase Uncoupling Induced by Loss of eNOS:BH4 Stoichiometry

  2021cites this paper
• Mitigation of Radiation-Induced Lung and Heart Injuries in Mice by Oral Sepiapterin after Irradiation

  2021cites this paper
• Sepiapterin reductase: Characteristics and role in diseases

  2020cites this paper
• Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ

  2019cites this paper
• Emerging therapies for small cell lung cancer

  2019cites this paper
• Imbalance between nitric oxide and superoxide anion induced by uncoupled nitric oxide synthase contributes to human melanoma development.

  2019cites this paper
• Sepiapterin Enhances Tumor Radio- and Chemosensitivities by Promoting Vascular Normalization

  2018cites this paper
• Randomized Phase II Trial of Cisplatin and Etoposide in Combination With Veliparib or Placebo for Extensive-Stage Small-Cell Lung Cancer: ECOG-ACRIN 2511 Study.

  2017cites this paper
• INTRODUCING NOVEL COMBINATORIAL TARGETED THERAPIES IN MULTIPLE TYPES OF CANCER

  2016influential citation
• Nitric Oxide Synthase Uncoupling in Tumor Progression and Cancer Therapy

  2016cites this paper
• Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex.

  2015cites this paper
• Nitric Oxide Synthase Activity and its Modulation in the Treatment of Colorectal Cancer

  2015cites this paper
• The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression

  2015influential citation
• Ionizing Radiation Induced Nitric Oxide Signaling

  2014cites this paper