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Molecular approaches to diagnosis of invasive aspergillosis; what we know and what we do not know

M. Moazeni,M. Nabili,S. Khodavaisy,H. Badali

Published 2013 in Research in Molecular Medicine

ABSTRACT

Invasive aspergillosis (IA) is a major complication in immunocompromized patients where can be serious and rapidly fatal. Ea rly diagnosis and appropriate antifungal treatment is important in reducing morta lity and morbidity. Despite many efforts to develop detection methods, the diag nosis of IA still remains challenging and current conventional methods are li mited for adequate diagnosis. New rapid methods which can detect IA early in the course of disease with high sensitivity and specificity are needed to treat the se infections at an early stage. Using molecular methods for the identification of Aspergillus species can be a cost-effective, rapid, discriminatory, and objectiv e approach for delineating Aspergillus species in a clinical microbiology laboratory. PCR techniques for the diagnosis of IA have been studied for more than a d ecade and are still considered investigational; however, until now PCR is not incl uded in current EORTC/MSG diagnostic criteria .

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