Noninterventional Treatment Options for Stroke.

Given the need for early restoration of blood flow and preservation of partially damaged brain cells after ischemic stroke, the noninterventional treatment of stroke relies heavily on the speedy recognition and classification of the clinical syndrome. Initiation of systemic thrombolysis with careful observation of contraindications within the 3.0 (4.5)-hour time window is the approved therapy of choice. Management of hemorrhagic complications and resumption of oral anticoagulation if indicated are also discussed in this article.

• Publication year

  2018

• Venue

  Neuroimaging clinics of North America

• Publication date

  2018-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.nic.2018.06.006PMID 30322599
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

  2018cited by this paper
• Current evidence of oral anticoagulant reversal: A systematic review.

  2018cited by this paper
• Outcome Measure Scores Predict Discharge Destination in Patients With Acute and Subacute Stroke: A Systematic Review and Series of Meta-analyses

  2018cited by this paper
• 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

  2018cited by this paper
• Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

  2018cited by this paper
• Therapies for Hemorrhagic Transformation in Acute Ischemic Stroke

  2017cited by this paper
• Controversies in Thrombolysis

  2017cited by this paper
• Pure motor monoparesis due to infarction of the "hand knob" area: radiological and morphological features

  2017cited by this paper
• Clinical Selection Strategies to Identify Ischemic Stroke Patients With Large Anterior Vessel Occlusion: Results From SITS-ISTR (Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Registry)

  2017cited by this paper
• Correction to: Clinical Selection Strategies to Identify Ischemic Stroke Patients With Large Anterior Vessel Occlusion: Results From SITS-ISTR (Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Registry).

  2017cited by this paper
• Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

  2017cited by this paper
• Stroke: Highlights of Selected Articles.

  2017cited by this paper
• The Association between Diffusion MRI‐Defined Infarct Volume and NIHSS Score in Patients with Minor Acute Stroke

  2017cited by this paper
• Neuroprotection in stroke: the importance of collaboration and reproducibility

  2017cited by this paper
• Rapid recovery from aphasia after infarction of Wernicke’s area

  2017cited by this paper
• Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial

  2017cited by this paper
• NubuckLight Sarto Smooth Smooth Richland Franco Bone Black Nubuck Satin Satin 3 xgZx7qY4 --wildwoodmotorsports.com

  2017cited by this paper
• Low-molecular-weight heparins or heparinoids versus standard unfractionated heparin for acute ischaemic stroke.

  2017cited by this paper
• Volume and functional outcome of intracerebral hemorrhage according to oral anticoagulant type

  2016cited by this paper
• Expanding the concept of neuroprotection for acute ischemic stroke: The pivotal roles of reperfusion and the collateral circulation.

  2016cited by this paper
• Why are acute ischemic stroke patients not receiving IV tPA?

  2016cited by this paper
• Prior Antithrombotic Use Is Associated With Favorable Mortality and Functional Outcomes in Acute Ischemic Stroke

  2016cited by this paper
• Degree and Timing of Intensive Blood Pressure Lowering on Hematoma Growth in Intracerebral Hemorrhage: Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial-2 Results

  2016cited by this paper
• Risks and Benefits Associated With Prestroke Antiplatelet Therapy Among Patients With Acute Ischemic Stroke Treated With Intravenous Tissue Plasminogen Activator.

  2016cited by this paper
• Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage.

  2016cited by this paper
• The critical care management of spontaneous intracranial hemorrhage: a contemporary review

  2016cited by this paper
• Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data

  2015cited by this paper
• Early Surgery versus Initial Conservative Treatment in Patients with Traumatic Intracerebral Hemorrhage (STITCH[Trauma]): The First Randomized Trial

  2015cited by this paper
• Threshold for NIH Stroke Scale in Predicting Vessel Occlusion and Functional Outcome after Stroke Thrombolysis

  2015cited by this paper
• Effect of Intravenous Recombinant Tissue-Type Plasminogen Activator in Patients With Mild Stroke in the Third International Stroke Trial-3: Post Hoc Analysis

  2015cited by this paper
• Impact of Collateral Status on Successful Revascularization in Endovascular Treatment: A Systematic Review and Meta-Analysis

  2015cited by this paper
• Race against the clock: overcoming challenges in the management of anticoagulant-associated intracerebral hemorrhage.

  2014cited by this paper
• Thrombolysis for acute ischaemic stroke.

  2014cited by this paper
• Rapid Warfarin reversal in the setting of intracranial hemorrhage: a comparison of plasma, recombinant activated factor VII, and prothrombin complex concentrate.

  2014cited by this paper
• Tranexamic acid for spontaneous intracerebral hemorrhage: a randomized controlled pilot trial (ISRCTN50867461).

  2014cited by this paper
• Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

  2013cited by this paper
• population based study of outcomes after evacuation of primary supratentorial ntracerebral hemorrhage

  2013cited by this paper
• Fresh frozen plasma: the most commonly prescribed hemostatic agent

  2013cited by this paper
• Fibrinogen concentrate and cryoprecipitate but not fresh frozen plasma correct low fibrinogen concentrations following in vitro haemodilution.

  2013cited by this paper
• Treatment of Intracerebral Hemorrhage with Tranexamic Acid After Thrombolysis with Tissue Plasminogen Activator

  2012cited by this paper
• Intra‐arterial vasodilator use during endovascular therapy for acute ischemic stroke might improve reperfusion rate

  2012cited by this paper
• Collateral Perfusion: Time for Novel Paradigms in Cerebral Ischemia

  2012cited by this paper
• Symptomatic Intracranial Hemorrhage following Intravenous Thrombolysis for Acute Ischemic Stroke: A Critical Review of Case Definitions

  2012cited by this paper
• Thrombolysis in acute ischaemic stroke.

  2012cited by this paper
• Clinical review: Prothrombin complex concentrates - evaluation of safety and thrombogenicity

  2011cited by this paper
• Predictors and Early Outcome of Hemorrhagic Transformation after Acute Ischemic Stroke

  2011cited by this paper
• Management of thrombolysis-associated symptomatic intracerebral hemorrhage.

  2010cited by this paper
• Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials.

  2010cited by this paper
• Factors Associated With Intracerebral Hemorrhage After Thrombolytic Therapy for Ischemic Stroke: Pooled Analysis of Placebo Data From the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II Trials

  2009cited by this paper
• Substantial Observer Variability in the Differentiation Between Primary Intracerebral Hemorrhage and Hemorrhagic Transformation of Infarction on CT Brain Imaging

  2009cited by this paper
• The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial.

  2009cited by this paper
• Ancrod in Acute Ischemic Stroke: Results of 500 Subjects Beginning Treatment Within 6 Hours of Stroke Onset in the Ancrod Stroke Program

  2009cited by this paper
• Baseline NIH Stroke Scale Responses Estimate the Probability of Each Particular Stroke Subtype

  2008cited by this paper
• Impact of Fever on Outcome in Patients With Stroke and Neurologic Injury: A Comprehensive Meta-Analysis

  2008cited by this paper
• Preventive Antibacterial Therapy in Acute Ischemic Stroke: A Randomized Controlled Trial

  2008cited by this paper
• Classification and pathogenesis of cerebral hemorrhages after thrombolysis in ischemic stroke.

  2006cited by this paper
• The Early Systemic Prophylaxis of Infection After Stroke Study: A Randomized Clinical Trial

  2005cited by this paper
• Low-Molecular-Weight Heparins or Heparinoids Versus Standard Unfractionated Heparin for Acute Ischemic Stroke

  2005cited by this paper
• Historical Observations on Functional Reorganization

  2004cited by this paper
• Midazolam Challenge Reinduces Neurological Deficits After Transient Ischemic Attack

  2003cited by this paper
• Neuroprotective agents in acute ischemic stroke.

  2002cited by this paper
• Anaphylactoid Reactions to Vitamin K

  2001cited by this paper
• Functional reorganization after lesions of the human brain: studies with transcranial magnetic stimulation.

  2001cited by this paper
• Effects of poststroke pyrexia on stroke outcome : a meta-analysis of studies in patients.

  2000cited by this paper
• Cerebral hemorrhage after systemic fibrinolysis in a patient with severe carotid artery stenosis.

  1999cited by this paper
• Case report Cerebral hemorrhage after systemic fibrinolysis in a patient with severe carotid artery stenosis

  1999cited by this paper
• Cost-effectiveness of tissue plasminogen activator for acute ischemic stroke

  1998cited by this paper
• Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke Prevention in Atrial Fibrillation III randomised clinical trial.

  1996cited by this paper
• A Randomized, Double‐blind, Placebo‐Controlled Trial of Nimodipine in Acute Ischemic Hemispheric Stroke

  1994cited by this paper
• Pilot randomized trial of tissue plasminogen activator in acute ischemic stroke. The TPA Bridging Study Group.

  1993cited by this paper
• Neuroradiologic evaluation of patients with acute stroke treated with recombinant tissue plasminogen activator. The rt-PA Acute Stroke Study Group.

  1993cited by this paper
• 'Spectacular shrinking deficit'

  1992cited by this paper
• Rapid reversible modulation of human motor outputs after transient deafferentation of the forearm

  1992cited by this paper
• Clinical trial of nimodipine in acute ischemic stroke. The American Nimodipine Study Group.

  1992cited by this paper
• Clinical Trial of Nimodipine in Acute Ischemic Stroke

  1992cited by this paper
• A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project 1981-86. 1. Methodology, demography and incident cases of first-ever stroke.

  1988cited by this paper
• The investigational use of tPA for stroke.

  1988cited by this paper
• The Pilot Stroke Data Bank: Definition, Design, and Data

  1984cited by this paper
• Broca aphasia

  1978cited by this paper
• The Harvard Cooperative Stroke Registry

  1978cited by this paper
• Superficial and deep anterosuperior Sylvian syndromes.

  1977cited by this paper
• Superficial and deep anterosuperior Sylvian syndromes.

  1977cited by this paper
• Rapid amelioration of motor aphasia.

  1973cited by this paper
• Vascular Health and Risk Management Dovepress Current Perspectives on the Use of Intravenous Recombinant Tissue Plasminogen Activator (tpa) for Treatment of Acute Ischemic Stroke

  year unknowncited by this paper

• Chiasmal and Retrochiasmal Disorders.

  2019cites this paper