Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: Colon cancer family registry

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Genes, Chromosomes and Cancer

• Publication date

  2014-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/gcc.22167PMID 24677636PMCID PMC4326223
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012influential reference
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  2012influential reference
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