Optogenetics to help exploring the cerebral blood flow regulation

Mammalian brain contains a rich vas-cular network. This network’s functionalactivity, i.e., blood flow, is tightly con-trolled by neural networks, although themechanisms of this control are not yetclear. Understanding the link betweenneuronal activity and cerebral blood flow(CBF) is essential for both theoretical andapplied aspects of brain vascular dysfunc-tions in neurodegenerative diseases (de laTorre, 2012). Optogenetic techniques pro-vide unique opportunities for monitoringand modulating functions of specific neu-rons and neuronal networks. An excellentexample is the recent study of Urban et al.(2012) on regulation of CBF in the mousebrain.Up till now, three main hypothe-sishavebeenputforwardtoexplainneuro-vascular coupling:

• Publication year

  2014

• Venue

  Frontiers in Pharmacology

• Publication date

  2014-05-13

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.3389/fphar.2014.00107PMID 24860507PMCID 4026704
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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