Andrographolide Prevents High-Fat Diet–Induced Obesity in C57BL/6 Mice by Suppressing the Sterol Regulatory Element-Binding Protein Pathway

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2014-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1124/jpet.114.217968PMID 25204338
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Faculty Opinions recommendation of Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha.

  2015cited by this paper
• Obesity pharmacotherapy: what is next?

  2013cited by this paper
• Molecular mechanisms underlying the anti-obesity potential of prunetin, an O-methylated isoflavone.

  2013cited by this paper
• SREBP: a novel therapeutic target.

  2013cited by this paper
• Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells.

  2013cited by this paper
• Statin use and risk of diabetes mellitus in postmenopausal women in the Women's Health Initiative.

  2012cited by this paper
• The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals.

  2012cited by this paper
• Clinical and laboratory phenotype of patients experiencing statin intolerance attributable to myalgia.

  2011cited by this paper
• Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques.

  2011influential reference
• Diagnosis, prevention, and management of statin adverse effects and intolerance: proceedings of a Canadian Working Group Consensus Conference.

  2011cited by this paper
• Management of the Patient with Statin Intolerance

  2010cited by this paper
• Evaluation of molecular pharmaceutical and in-vivo properties of spray-dried isolated andrographolide-PVP.

  2009cited by this paper
• The LDL receptor.

  2009cited by this paper
• Metabolic syndrome as a predictor of cardiovascular diseases and type 2 diabetes in Koreans.

  2009cited by this paper
• Physicochemical characteristics and oral bioavailability of andrographolide complexed with hydroxypropyl-beta-cyclodextrin.

  2009cited by this paper
• A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappaB pathway.

  2009cited by this paper
• Genetic predisposition to statin myopathy

  2008cited by this paper
• Hepatoprotective Effect of Andrographolide Against Hexachlorocyclohexane-Induced Oxidative Injury

  2007cited by this paper
• PPARα and dyslipidemia

  2007cited by this paper
• PPARalpha and dyslipidemia.

  2007cited by this paper
• Abdominal obesity and metabolic syndrome

  2006cited by this paper
• Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation.

  2006cited by this paper
• Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues Published, JLR Papers in Press, January 1, 2005. DOI 10.1194/jlr.M400261-JLR200

  2005cited by this paper
• Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of Peroxisome Proliferator-Activated Receptor γ Expression

  2004cited by this paper
• Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits.

  2004cited by this paper
• The obesity epidemic, metabolic syndrome and future prevention strategies

  2004cited by this paper
• Hepatic steatosis in obese patients: clinical aspects and prognostic significance

  2004cited by this paper
• Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

  2003influential reference
• T‐0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor‐deficient mice

  2003cited by this paper
• SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

  2002cited by this paper
• Synthetic LXR ligand inhibits the development of atherosclerosis in mice

  2002cited by this paper
• Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

  2002influential reference
• Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β*

  2002cited by this paper
• Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes.

  2001cited by this paper
• Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis.

  2001cited by this paper
• Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

  2001cited by this paper
• Gene expression of sterol regulatory element-binding proteins in hamster small intestine.

  2001influential reference
• Role of LXRs in control of lipogenesis.

  2000influential reference
• Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

  2000cited by this paper
• Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.

  2000influential reference
• Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

  2000cited by this paper
• Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha.

  1998cited by this paper
• Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

  1998cited by this paper
• The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.

  1997cited by this paper
• ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.

  1996cited by this paper
• Effect of lovastatin on cholesterol absorption in cholesterol-fed rabbits.

  1993cited by this paper
• New methods for calculating metabolic rate with special reference to protein metabolism

  1949influential reference
• A Novel Antiinflammatory Role for Andrographolide in Asthma via Inhibition of the Nuclear Factor-kb Pathway

  year unknowncited by this paper

• Botany, phytochemistry, and hepatoprotective properties of Kalmegh [Andrographis paniculata (Burm. f.) Wall. ex Nees]: A review

  2025cites this paper
• Andrographis paniculata in Fatty Liver Disease: Mechanisms, Nanocarrier Approaches, and Therapeutic Potential

  2025cites this paper
• The effect of andrographolides as the main bioactive compound of Andrographis paniculata on insulin resistance using in vivo approach: A systematic review

  2025cites this paper
• Therapeutic strategies targeting SREBP transcription factors: an update to 2024

  2025cites this paper
• Andrographolide Inhibits the NF-κB Signaling Pathway and Alleviates High-Fat Diet-Induced Hepatic Inflammation in a Mouse Model of Nonalcoholic Fatty Liver Disease

  2025cites this paper
• Hepato-specific activity of Andrographolide, a major constituent of Andrographis paniculata (Burm. f.) Wall. ex Nees for targeting liver diseases

  2025cites this paper
• The Role of Chinese Medicine as a Complementary Therapy in the Management of Obesity-Associated Colorectal Cancer.

  2025cites this paper
• Mitigating digestive disorders: Action mechanisms of Mediterranean herbal active compounds

  2024cites this paper
• Exploring the potential of andrographis paniculata and its bioactive compounds in the management of liver diseases: A comprehensive food chemistry perspective

  2024cites this paper
• Andrographolide Attenuates Myocardial Ischemia–Reperfusion Injury in Mice by Up-Regulating PPAR-α

  2024cites this paper
• Mathurameha ameliorates cardiovascular complications in high-fat diet/low-dose streptozotocin-induced type 2 diabetic rats: insights from histological and proteomic analysis

  2024cites this paper
• Activation of pregnane X receptor sensitizes alcoholic steatohepatitis by transactivating fatty acid binding protein 4

  2024cites this paper
• Emerging mechanisms of non-alcoholic steatohepatitis and novel drug therapies.

  2024cites this paper
• Utilizing Andrographis paniculata leaves and roots by effective usage of the bioactive andrographolide and its nanodelivery: investigation of antikindling and antioxidant activities through in silico and in vivo studies

  2023cites this paper
• Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases

  2023cites this paper
• Vitamin D3 alleviates nonalcoholic fatty liver disease in rats by inhibiting hepatic oxidative stress and inflammation via the SREBP-1-c/ PPARα-NF-κB/IR-S2 signaling pathway

  2023cites this paper
• Promising hepatoprotective agents from the natural sources: a study of scientific evidence

  2023cites this paper
• The role of Andrographolide in the prevention and treatment of liver diseases.

  2023cites this paper
• The Potential Chemopreventive Effect of Andrographis paniculata on 1,2-Dimethylhydrazine and High-Fat-Diet-Induced Colorectal Cancer in Sprague Dawley Rats

  2023cites this paper
• Quantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue

  2023cites this paper
• Optimizing Energy Efficiency in Multidevice Communication with Artificial Intelligence Assistance

  2023cites this paper
• Andrographolide attenuated MCT-induced HSOS via regulating NRF2-initiated mitochondrial biogenesis and antioxidant response

  2023cites this paper
• Identification of Andrographolide as an Agonist of Bile Acid TGR5 Receptor in a Cell Line to Demonstrate the Reduction in Hyperglycemia in Type-1 Diabetic Rats

  2023cites this paper
• Fenofibrate and Diosmetin in a rat model of testicular toxicity: New insight on their protective mechanism through PPAR-α/NRF-2/HO-1 signaling pathway.

  2023cites this paper
• Hypoglycemic and hypolipidemic effects of Epigynum auritum in high fat diet and streptozotocin-induced diabetic rats.

  2022cites this paper
• Andrographolide Promotes Uptake of Glucose and GLUT4 Transport through the PKC Pathway in L6 Cells

  2022cites this paper
• Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease

  2022influential citation
• Natural Compounds as Oriental Therapy for Liver Protection against Inflammatory and Carcinogenic Mechanisms: from Induction to Molecular Biology Advancement.

  2022cites this paper
• Study on the mechanism of andrographolide activation

  2022cites this paper
• Effects of Resveratrol Against Induced Metabolic Syndrome in Rats: Role of Oxidative Stress, Inflammation, and Insulin Resistance

  2022cites this paper
• Identification of potential andrographolide-based drug candidate against Keap1-Nrf2 pathway through rigorous cheminformatics screening

  2022cites this paper
• Andrographolide and its derivatives: Current achievements and future perspectives.

  2021cites this paper
• An in-silico approach to identify the potential hot spots in SARS-CoV-2 spike RBD to block the interaction with ACE2 receptor

  2021cites this paper
• Hepatoprotective effect of selected isoandrographolide derivatives on steatotic HepG2 cells and High Fat Diet fed rats.

  2021cites this paper
• Pharmacology and Mechanisms of Natural Medicine in Treatment of Type 2 Diabetes Mellitus

  2021cites this paper
• Andrographolide prevents bone loss via targeting estrogen‐related receptor‐α‐regulated metabolic adaption of osteoclastogenesis

  2021cites this paper
• Investigating pharmacological mechanisms of andrographolide on non-alcoholic steatohepatitis (NASH): A bioinformatics approach of network pharmacology

  2021cites this paper
• Preventive potential of Andrographis paniculata-derived compounds in metabolic syndrome-associated prostate cancer: A narrative review on the mechanism of action

  2021cites this paper
• Modeling Diet-Induced Metabolic Syndrome in Rodents.

  2020cites this paper
• Andrographis paniculata Improves Insulin Resistance in High-Fat Diet-Induced Obese Mice and TNFα-Treated 3T3-L1 Adipocytes.

  2020cites this paper
• Andrographolide modulates HNF4α activity imparting on hepatic metabolism.

  2020cites this paper
• Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism

  2020cites this paper
• Gut Microbiota Mediates the Protective Effects of Andrographolide Inhibits Inflammation and Nonalcoholic Fatty Liver Disease(NAFLD) in High-Fat Diet induced ApoE(-/-) Mice

  2020cites this paper
• Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway

  2020cites this paper
• Andrographolide attenuates imbalance of gastric vascular homeostasis induced by ethanol through glycolysis pathway

  2019cites this paper
• Andrographolide is an Alternative Treatment to Overcome Resistance in ER-Positive Breast Cancer via Cholesterol Biosynthesis Pathway

  2019cites this paper
• Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer

  2019cites this paper
• Antidiabetic herbal medicines rebranded as dietary supplements

  2019cites this paper
• Role of SREBPs in Liver Diseases: A Mini-review

  2018cites this paper
• Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms

  2018cites this paper
• Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer.

  2018cites this paper
• Resveratrol improves high-fat diet induced fatty liver and insulin resistance by concomitantly inhibiting proteolytic cleavage of sterol regulatory element-binding proteins, free fatty acid oxidation, and intestinal triglyceride absorption.

  2018cites this paper
• Effects of Sambiloto Ethanol Extract on Fatty Liver, SGOT/SGPT Levels and Lipid Profile of Wistar Strain White Rat (Rattus norvegicus) Exposed to High-Fat Diet

  2018cites this paper
• Andrographolide attenuates viral myocarditis through interactions with the IL-10/STAT3 and P13K/AKT/NF-κβ signaling pathways.

  2018cites this paper
• University of Groningen Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

  2017cites this paper
• Methanolic Extract of Clinacanthus nutans Leaves can Alter AdipocyteCellularity, Inflammation and Acetyl Cholinesterase Activity in Male ObeseMice

  2017cites this paper
• Andrographolide Benefits Rheumatoid Arthritis via Inhibiting MAPK Pathways

  2017cites this paper
• Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

  2017cites this paper
• Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome

  2017cites this paper
• Effect of two andrographolide derivatives on cellular and rodent models of non-alcoholic fatty liver disease.

  2017cites this paper
• Plantago asiatica L. Seed Extract Improves Lipid Accumulation and Hyperglycemia in High-Fat Diet-Induced Obese Mice

  2017cites this paper
• Andrographolide protects liver cells from H2O2 induced cell death by upregulation of Nrf-2/HO-1 mediated via adenosine A2a receptor signalling.

  2016cites this paper
• Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway.

  2016cites this paper
• Andrographolide inhibits adipogenesis of 3T3-L1 cells by suppressing C/EBPβ expression and activation.

  2016cites this paper
• A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives

  2015cites this paper
• Biological and Pharmacological Activities of Andrographis spp. (Acanthaceae) Distributed in Southern Eastern Ghats, India

  2015cites this paper
• MODULATION OF TOTAL CHOLESTEROL AND TRIGLYCERIDE IN PLASMODIUM BERGHEI INFECTED MICE BY AQUEOUS CRUDE EXTRACT OF ANDROGRAPHIS PANICULATA

  2015cites this paper
• International Journal of Current Research in

  2014cites this paper