Laser speckle contrast imaging of blood flow in the deep brain using microendoscopy.

Poor blood flow circulation can occur in the subcortical regions of the brain in many brain diseases. However, the limitations of light penetration imaging techniques hinder the detection of blood flow in deep brain tissues in vivo. Hence, in this Letter, we present a gradient index lens-based laser speckle contrast imaging system for time-lapse blood flow detection in subcortical regions of the brain. We monitored the hemodynamic changes in the thalamus of mouse models of acute hypoxia and transient middle cerebral artery occlusion as a proof of concept for practical applications.

• Publication year

  2018

• Venue

  Optics Letters

• Publication date

  2018-11-14

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1364/OL.43.005627PMID 30439911
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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