A Concerted Synchronous [2 + 2] Cycloreversion Repair Catalyzed by Two Electrons.

The current understanding of photoenzyme-catalyzed [2 + 2] cycloreversion repair of cyclobutane pyrimidine dimer (CPD) is that a photogenerated electron from the photolyase enzyme catalyzes the repair. This one-electron catalyzed repair is a sequential two-bond breaking cycloreversion of the cyclobutane center and involves a negative ion radical as an intermediate. Here, by resonantly capturing two exogenous low-energy electrons into the molecular field of a CPD, we show that the concerted synchronous two-bond breaking reaction, which is intermediate-free, and hence a safe repair, is feasible through two-electron catalysis.

• Publication year

  2018

• Venue

  Journal of Physical Chemistry Letters

• Publication date

  2018-11-27

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.jpclett.8b03256PMID 30481035
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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