Endoplasmic reticulum calcium dictates the distribution of intracellular unesterified cholesterol.

Endoplasmic reticulum (ER) luminal Ca2+ influences many functions of this organelle, notably the synthesis and quality control of proteins and lipids. Cholesterol is an essential component of biological membranes and a precursor for many biologically important signaling molecules. The sterol regulatory element-binding proteins (SREBPs) are key regulators of lipid metabolism. These transcription factors are synthesized as ER membrane-bound precursor proteins that are proteolytically processed in response to cellular cholesterol status. Recently, ER Ca2+ status was shown to be an important determinant of the basal sensitivity of the sterol sensing mechanism inherent to the SREBP processing pathway. This article discusses the emerging relationship between cellular Ca2+ and cholesterol metabolism.

• Publication year

  2018

• Venue

  Cell Calcium

• Publication date

  2018-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ceca.2018.11.002PMID 30463032
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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