Temporality in chronic diseases and adherence to long-term therapies: From philosophy to science and back.

This narrative review exhibits the construction and validation of a hypothesis to explain how treatment non-adherence in people with chronic disease, a major issue in contemporary medicine, occurs. I propose that non-adherence to long-term therapies is at least in part due to failure to prioritize the future, which is caused by a condition I dub disruption in time projection. This article gives the rationale for this hypothesis, which is largely grounded on philosophical arguments. Then, it demonstrates the plausibility of the hypothesis: on the one hand, it is consistent with certain epidemiological data found in the literature. On the other, it is possible to predict the underlying mechanisms of this lack of prioritization from recent achievements of neuro-economics and neuroscience. Next, it reviews empirical data that provide an experimental verification for this explanatory hypothesis. Finally, a general evolutionary and philosophical meaning for adherence is proposed, considering the advantages of its preconditions, namely, patience and foresight.

• Publication year

  2019

• Venue

  Diabetes & Metabolism

• Publication date

  2019-10-01

• Fields of study

  Medicine, Philosophy, Psychology

• Identifiers
  DOI 10.1016/j.diabet.2018.11.002PMID 30472197
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Holistic psychosocial determinants of adherence to medication in people with type 2 diabetes.

  2018cited by this paper
• Disruption in time projection and non-adherence to long-term therapies

  2018cited by this paper
• Introduction [Chapter 1]

  2018cited by this paper
• The Strength Model of Self-Regulation: Conclusions From the Second Decade of Willpower Research

  2018cited by this paper
• Socioeconomic inequality in medication persistence in primary and secondary prevention of coronary heart disease – A population-wide electronic cohort study

  2018cited by this paper
• The neural basis of delay discounting: A review and preliminary model

  2017cited by this paper
• Medication adherence and improved outcomes among patients with type 2 diabetes.

  2017cited by this paper
• Association Between Adherence to Pharmacotherapy and Outcomes in Type 2 Diabetes: A Meta-analysis

  2017cited by this paper
• Is patient empowerment the key to promote adherence? A systematic review of the relationship between self-efficacy, health locus of control and medication adherence

  2017cited by this paper
• Patient education, nudge, and manipulation: defining the ethical conditions of the person-centered model of care

  2016cited by this paper
• Association between Impulsivity and Weight Status in a General Population

  2016cited by this paper
• Delay discounting of gains and losses, glycemic control and therapeutic adherence in type 2 diabetes.

  2016cited by this paper
• The dual systems model: Review, reappraisal, and reaffirmation

  2015cited by this paper
• A Systematic Review of Interventions Addressing Adherence to Anti-Diabetic Medications in Patients with Type 2 Diabetes—Impact on Adherence

  2015cited by this paper
• Adherence to Oral Glucose-Lowering Therapies and Associations With 1-Year HbA1c: A Retrospective Cohort Analysis in a Large Primary Care Database

  2015cited by this paper
• The relationship of psychological reactance, health locus of control and sense of self-efficacy with adherence to treatment in psychiatric outpatients with depression

  2014cited by this paper
• Time and Risk Preferences and the Use of Asthma Controller Medication

  2013cited by this paper
• Sensing sound: molecules that orchestrate mechanotransduction by hair cells.

  2012cited by this paper
• Patients' impatience is an independent determinant of poor diabetes control.

  2011cited by this paper
• Obedience and motivation as mechanisms for adherence to medication: a study in obese type 2 diabetic patients

  2011cited by this paper
• Getting hooked

  2011cited by this paper
• Maturation of limbic corticostriatal activation and connectivity associated with developmental changes in temporal discounting

  2011cited by this paper
• Une théorie du soin. Souci et amour face à la maladie

  2010cited by this paper
• Hyperbolic discounting, the sign effect, and the body mass index.

  2010cited by this paper
• Construal-level theory of psychological distance.

  2010cited by this paper
• Is there an impatience genotype leading to non-adherence to long-term therapies?

  2010cited by this paper
• Effects of the Val158Met catechol-O-methyltransferase polymorphism on cortical structure in children and adolescents

  2009cited by this paper
• Temporal horizon: modulation by smoking status and gender.

  2009cited by this paper
• Patient trust‐in‐physician and race are predictors of adherence to medical management in inflammatory bowel disease

  2009cited by this paper
• Improving the Prediction of Medication Compliance: The Example of Bisphosphonates for Osteoporosis

  2009cited by this paper
• Reasoning: Breakdown of Will

  2008cited by this paper
• Obese women show greater delay discounting than healthy-weight women.

  2008cited by this paper
• Comparison of Drug Adherence Rates Among Patients with Seven Different Medical Conditions

  2008cited by this paper
• Is a bird in the hand worth two in the future? The neuroeconomics of intertemporal decision-making.

  2008cited by this paper
• A novel conceptual framework for understanding the mechanism of adherence to long term therapies

  2008cited by this paper
• The role of impulsive behavior in drug abuse

  2008cited by this paper
• Continuous glucose monitoring and intensive treatment of type 1 diabetes.

  2008cited by this paper
• Cigarette smokers discount past and future rewards symmetrically and more than controls: is discounting a measure of impulsivity?

  2008cited by this paper
• Immediate Reward Bias in Humans: Fronto-Parietal Networks and a Role for the Catechol-O-Methyltransferase 158Val/Val Genotype

  2007cited by this paper
• Regulation of firing of dopaminergic neurons and control of goal-directed behaviors.

  2007cited by this paper
• Socioeconomic disadvantage and primary non-adherence with medication in Sweden.

  2007cited by this paper
• Construal levels and self-control.

  2006cited by this paper
• A meta-analysis of the association between adherence to drug therapy and mortality

  2006cited by this paper
• Maturity and adherence in adolescent and young adult heart recipients

  2006cited by this paper
• Adherence to Oral Hypoglycemic Agents in Hawaii

  2005cited by this paper
• Abduction and the Semiotics of Perception

  2005cited by this paper
• Role of habit in adherence to medical treatment

  2005cited by this paper
• OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR SUBJECTIVE PROBABILITY AND DELAY

  2005cited by this paper
• The Reasons of Love

  2004cited by this paper
• CHAPTER TWENTY-SIX. Out of Control: Visceral Influences on Behavior

  2004cited by this paper
• Abduction as a Logic and Methodology of Discovery: the Importance of Strategies

  2004cited by this paper
• How is Strength of Will Possible

  2003cited by this paper
• Delay discounting: A fundamental behavioral process of drug dependence

  2003cited by this paper
• Interventions for helping patients to follow prescriptions for medications.

  2002cited by this paper
• How Is Weakness of the Will Possible

  2001cited by this paper
• [Application of the causal theory of action through analysis of therapeutic non-observance].

  2000cited by this paper
• Psychological Reactance as a Factor in Patient Noncompliance With Medication Taking: A Field Experiment1

  2000cited by this paper
• Introduction (Chapter 1)

  2000cited by this paper
• Getting Hooked: Addiction, Weakness of the Will, and Relapse

  1999cited by this paper
• Linking primary care performance to outcomes of care.

  1998cited by this paper
• Adherence to insulin treatment, glycaemic control, and ketoacidosis in insulin-dependent diabetes mellitus. The DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside Scotland. Medicines Monitoring Unit.

  1997cited by this paper
• THE NATURE OF RATIONALITY

  1995cited by this paper
• Descartes' error: emotion, reason, and the human brain. avon books

  1994cited by this paper
• The consideration of future consequences: Weighing immediate and distant outcomes of behavior.

  1994cited by this paper
• Delay of gratification in children.

  1989cited by this paper
• The importance of what we care about: The importance of what we care about

  1988cited by this paper
• “Civilization” and its discontents

  1987cited by this paper
• Reasons and Persons

  1986cited by this paper
• Actions, Reasons, And Causes

  1980cited by this paper
• Advice To A Young Scientist

  1979cited by this paper
• HOME MONITORING OF BLOOD-GLUCOSE: Method for Improving Diabetic Control

  1978cited by this paper
• Continuous subcutaneous insulin infusion: an approach to achieving normoglycaemia.

  1978cited by this paper
• Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus.

  1976cited by this paper
• Heuristics and Biases

  1974cited by this paper
• Impulse control in pigeons.

  1974cited by this paper
• [Evolution of hormonal parameters (glucagon, cortisol, growth hormone) and energetic parameters (glucose, fatty acids, free glycerol) in 10 severe cases of diabetic acido-ketosis under treatment].

  1969cited by this paper

• A Machine Learning Model to Predict Patients’ Adherence Behavior and a Decision Support System for Patients With Metastatic Breast Cancer: Protocol for a Randomized Controlled Trial

  2023cites this paper
• Psychological care of patients during the pancreas transplantation process: issues and prospects

  2023cites this paper
• Puerperium experience and lifestyle in women with gestational diabetes mellitus and overweight/obesity in China: A qualitative study

  2023cites this paper
• Observance en médecine

  2022cites this paper
• 2022 Prevention of chronic non-communicable diseases in Of the Russian Federation. National guidelines

  2022cites this paper
• Rapport 21-09. La relation médecin-malade

  2021cites this paper
• Staying connected: the importance of timely communication for young people living with a long-term condition and their clinical teams

  2021influential citation
• Intentionality in adherence to long-term therapies. Results from an online survey of 3,001 patients with cardio-metabolic pathologies in France

  2021cites this paper
• Postpartum lifestyle modifications for women with gestational diabetes: A qualitative study.

  2020cites this paper
• Illness and two meanings of phenomenology.

  2020cites this paper
• Translation and solidarity in the century with no future: prefiguration vs. aspirational translation

  2020cites this paper
• Decisions in the Psychology of Glucose Monitoring

  2019cites this paper
• Implication Of Character Traits In Adherence To Treatment In People With Gout: A Reason For Considering Nonadherence As A Syndrome

  2019cites this paper
• Implication Of Character Traits In Adherence To Treatment In People With Gout: A Reason For Considering Nonadherence As A Syndrome

  2019cites this paper