The biosafety of molecular farming in plants

Molecular farming in plants provides an inexpensive and convenient way to produce biopharmaceutical molecules and other valuable proteins on a large scale. Proof of principle has been demonstrated for a large number of recombinant human proteins, subunit vaccines and antibodies, and detailed cost evaluations have been described for the production of technical proteins in maize. In terms of biosafety, plants have several advantages over traditional production systems, such as the absence of endotoxins, human pathogens and oncogenic DNA sequences. However, other biosafety concerns remain to be addressed. These not only reflect the quality and safety of the final product, but also the wider effects of molecular farming on health and the environment. In this review we discuss the technological basis of molecular farming in plants and identify potential biosafety risks: transgene spread in the environment, recombinant protein accumulation in the ecosystem, contamination of food and feed chains with transgenes and their products, and product quality and safety.

• Publication year

  2003

• Venue

  CABI Reviews

• Publication date

  2003-01-01

• Fields of study

  Biology, Agricultural and Food Sciences, Environmental Science

• Identifiers
  DOI 10.1079/cabireviews20033177371
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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