Midkine promotes tetraspanin-integrin interaction and induces FAK-Stat1alpha pathway contributing to migration/invasiveness of human head and neck squamous cell carcinoma cells.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2008-12-12

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bbrc.2008.09.138PMID 18851943
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes

  2008cited by this paper
• Midkine is a NF-κB-inducible gene that supports prostate cancer cell survival

  2008cited by this paper
• Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression

  2008cited by this paper
• Truncated midkine correlates with sensitivity to anticancer drugs and malignancy in human tumor cell line

  2007cited by this paper
• Functional atlas of the integrin adhesome

  2007cited by this paper
• Guidelines for the selection of effective short-interfering RNA sequences for functional genomics.

  2007cited by this paper
• Pleiotrophin, A Multifunctional Tumor Promoter Through Induction of Tumor Angiogenesis, Remodeling of the Tumor Microenvironment, and Activation of Stromal Fibroblasts

  2007cited by this paper
• Overexpression of glycosylphosphatidylinositol (GPI) transamidase subunits phosphatidylinositol glycan class T and/or GPI anchor attachment 1 induces tumorigenesis and contributes to invasion in human breast cancer.

  2006cited by this paper
• Involvement of Ets-1 transcription factor in inducing matrix metalloproteinase-2 expression by epithelial-mesenchymal transition in human squamous carcinoma cells.

  2006cited by this paper
• Matrix Metalloproteinases 21 and 26 Are Differentially Expressed in Esophageal Squamous Cell Cancer

  2006cited by this paper
• A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions

  2006cited by this paper
• Midkine, a heparin-binding growth factor, produced by the host enhances metastasis of Lewis lung carcinoma cells.

  2006cited by this paper
• Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells

  2005cited by this paper
• α4β1- and α6β1-integrins are functional receptors for midkine, a heparin-binding growth factor

  2004cited by this paper
• Expressions of Matrix Metalloproteinases in Early-Stage Oral Squamous Cell Carcinoma as Predictive Indicators for Tumor Metastases and Prognosis

  2004cited by this paper
• FAK and paxillin

  2004cited by this paper
• Recruitment of focal adhesion kinase and paxillin to β1 integrin promotes cancer cell migration via mitogen activated protein kinase activation

  2004cited by this paper
• alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.

  2004cited by this paper
• Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma.

  2004cited by this paper
• Increased serum midkine concentration as a possible tumor marker in patients with superficial esophageal cancer.

  2003cited by this paper
• Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain.

  2003cited by this paper
• PKCε is a permissive link in integrin-dependent IFN-γ signalling that facilitates JAK phosphorylation of STAT1

  2003cited by this paper
• PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1.

  2003cited by this paper
• Growth factor-enhanced expression and activity of matrix metalloproteases in human non-small cell lung cancer cell lines.

  2003cited by this paper
• A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397.

  2003cited by this paper
• Introduction of midkine gene into human bladder cancer cells enhances their malignant phenotype but increases their sensitivity to antiangiogenic therapy.

  2003cited by this paper
• A transcriptional progression model for head and neck cancer.

  2003cited by this paper
• Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas.

  2003cited by this paper
• An extracellular site on tetraspanin CD151 determines α3 and α6 integrin–dependent cellular morphology

  2002cited by this paper
• AlphaVbeta6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9.

  2001cited by this paper
• αvβ6integrin promotes invasion of squamous carcinoma cells through up‐regulation of matrix metalloproteinase‐9

  2001cited by this paper
• Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck.

  2001cited by this paper
• Focal Adhesion Kinase Activates Stat1 in Integrin-mediated Cell Migration and Adhesion*

  2001cited by this paper
• Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells.

  2001cited by this paper
• Expression of the αvβ6 Integrin Promotes Migration and Invasion in Squamous Carcinoma Cells

  2001cited by this paper
• The tetraspanin CD9 associates with the integrin alpha6beta4 in cultured human epidermal keratinocytes and is involved in cell motility.

  2000cited by this paper
• Integrin Modulation by Lateral Association*

  2000cited by this paper
• The Tetraspan Molecule Cd151, a Novel Constituent of Hemidesmosomes, Associates with the Integrin α6β4 and May Regulate the Spatial Organization of Hemidesmosomes

  2000cited by this paper
• Characterization of Integrin–Tetraspanin Adhesion Complexes

  1999cited by this paper
• Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin-binding growth and differentiation factors.

  1999cited by this paper
• Binding of paxillin to α4 integrins modifies integrin-dependent biological responses

  1999cited by this paper

• Pharmacological Targeting of Midkine (MDK) Reveals Stiffness-Dependent Control of Hepatocellular Carcinoma Invasiveness.

  2026cites this paper
• Laryngeal sarcomatoid carcinoma: a case report and literature review on potential molecular targets for therapeutic opportunities

  2025cites this paper
• Spatial analysis of HPV‐associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cancer progression

  2024cites this paper
• The role of midkine in health and disease

  2023cites this paper
• Insight into the mechanism of CD34+ cell mobilisation impairment in multiple myeloma patients treated with anti‐CD38 therapy

  2023cites this paper
• Nasopharynx Battlefield: Cellular Immune Responses Mediated by Midkine in Nasopharyngeal Carcinoma and COVID-19

  2023cites this paper
• Midkine—A novel player in cardiovascular diseases

  2022cites this paper
• IGF1R and Src inhibition induce synergistic cytotoxicity in HNSCC through inhibition of FAK

  2021cites this paper
• TSPAN1, a novel tetraspanin member highly involved in carcinogenesis and chemoresistance.

  2021cites this paper
• TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance

  2020cites this paper
• Role of Focal Adhesion Kinase in Head and Neck Squamous Cell Carcinoma and Its Therapeutic Prospect

  2020cites this paper
• OTT_A_270342 10207..10220

  2020cites this paper
• Inhibition of midkine by metformin can contribute to its anticancer effects in malignancies: A proposal mechanism of action of metformin in context of endometrial cancer prevention and therapy.

  2019cites this paper
• Effect of magnesium ions/Type I collagen promote the biological behavior of osteoblasts and its mechanism

  2019cites this paper
• Characterization of Midkine in tongue sole (Cynoglossus semilaevis)and its role on the germ layer genesis in zebrafish (Danio rerio).

  2018cites this paper
• https://researchopenworld.com/the-impact-of-p-glycoprotein-and-midkine-on-paclitaxel-cisplatin-chemoresistance-in-ovarian-cancer/#

  2018cites this paper
• 3,3'-Diindolylmethane (DIM) decrease adhesion, migration and invasion in human prostate cancer cells

  2015cites this paper
• Improvement of Radiotherapy-Induced Lacrimal Gland Injury by Induced Pluripotent Stem Cell-Derived Conditioned Medium via MDK and Inhibition of the p38/JNK Pathway

  2014cites this paper
• Midkine expression in high grade gliomas: Correlation of this novel marker with proliferation and survival in human gliomas

  2014cites this paper
• Estrogen-responsive genes for environmental studies

  2014cites this paper
• Pancreatic cancer

  2014influential citation
• Structure and function of midkine as the basis of its pharmacological effects

  2014influential citation
• Chapter 12 Aquaporin , Midkine and Glioblastoma

  2013cites this paper
• The Role of Tetraspanins in Cell Migration and Intercellular Adhesion

  2013cites this paper
• Tetraspanins

  2013cites this paper
• Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

  2013cites this paper
• Aquaporin, Midkine and Glioblastoma

  2013cites this paper
• In-depth Characterization of the Secretome of Colorectal Cancer Metastatic Cells Identifies Key Proteins in Cell Adhesion, Migration, and Invasion*

  2013cites this paper
• Study of RNA Interference Targeting NET-1 Combination with Sorafenib for Hepatocellular Carcinoma Therapy In Vitro and In Vivo

  2013cites this paper
• Midkine/P63 Axis in Regulation of Epithelial-Mesenchymal Transition

  2012cites this paper
• Midkine in Glioblastoma with the Modulator Role Switching Autophagy to Cell Death or Cell Survival

  2012cites this paper
• Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer.

  2011cites this paper
• Midkine: A Promising Molecule for Drug Development to Treat Diseases of the Central Nervous System

  2011cites this paper
• Midkine Signaling in Glioblastoma: A Novel Developmental Drug Target?

  2011cites this paper
• Midkine in Inflammation

  2011cites this paper
• Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases

  2010cites this paper
• Midkine: A Novel Prognostic Biomarker for Cancer

  2010cites this paper
• Loquat (Eriobotrya japonica) extracts suppress the adhesion, migration and invasion of human breast cancer cell line

  2009cites this paper
• Vascular smooth muscle cells promote endothelial cell adhesion via microtubule dynamics and activation of paxillin and the extracellular signal-regulated kinase (ERK) pathway in a co-culture system.

  2009cites this paper
• Midkine translocated to nucleoli and involved in carcinogenesis.

  2009cites this paper