Quantitative genetic variation of resistance against Piscirickettsia salmonis in Atlantic salmon (Salmo salar)

Abstract Piscirickettsiosis ( Piscirickettsia salmonis ) is one of the diseases that cause large economic losses in Chilean salmon industry. Genetic improvement of disease resistance represents one strategy for controlling infectious diseases in farmed fish. However, knowledge of whether genetic variation exists for piscirickettsiosis resistance is needed in order to determine the feasibility of including this trait into the breeding goal. Using data from a challenge test performed on 2601 Atlantic salmon ( Salmo salar ) from 118 full-sib groups (40 half-sib groups) we found significant genetic variation for resistance to piscirickettsiosis. We used a cross-sectional linear model (CSL) and a binary threshold (probit) model (THR) to analyze the test-period survival, a linear model (LIN), Cox (COX) and Weibull (WB) frailty proportional hazard models to analyse the day at death, and a survival score (SS) model with a logit link to analyze the test-day survival. The estimated heritabilities for the different models ranged from 0.11 (SS) to 0.41 (COX). The Pearson and Spearman correlation coefficients between full-sib families estimated breeding values (EBVs) from the six statistical models were above 0.96 and 0.97, respectively. We used different data subsets, splitting the entire dataset both at random and by tank, in order to predict the accuracy of selection for each model. In both cases COX (0.8 and 0.79) and CSL (0.76 and 0.71) models showed the highest and the lowest accuracy of selection, respectively. These results indicate that resistance against P. salmonis in Atlantic salmon might be genetically improved more efficiently by means of using models which take both time to death and data censoring into account in the genetic evaluations.

• Publication year

  2013

• Venue

  Aquaculture

• Publication date

  2013-11-15

• Fields of study

  Biology, Environmental Science

• Identifiers
  DOI 10.1016/J.AQUACULTURE.2013.08.009
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The importance of selective breeding in aquaculture to meet future demands for animal protein: A review

  2012cited by this paper
• Methodology for genetic evaluation of disease resistance in aquaculture species: challenges and future prospects

  2011cited by this paper
• Survival Kit v6-a Software Package for Survival Analysis

  2010influential reference
• Factores genéticos que inciden en la resistencia a enfermedades infecciosas en salmónidos y su aplicación en programas de mejoramiento

  2010cited by this paper
• Evaluation of statistical models for genetic analysis of challenge-test data on ISA resistance in Atlantic salmon (Salmo salar): Prediction of progeny survival

  2007cited by this paper
• Genetic parameters and accuracy of selection for resistance to white Spot Syndrome Virus (WSSV) in Penaeus (Litopenaeus) vannamei using different statistical models

  2006influential reference
• Evaluation of statistical models for genetic analysis of challenge test data on furunculosis resistance in Atlantic salmon (Salmo salar): Prediction of field survival

  2006influential reference
• Design of Breeding Programs

  2005cited by this paper
• Genetic variance and covariance for 0+ brook charr (Salvelinus fontinalis) weight and survival time of furunculosis (Aeromonas salmonicida) exposure

  2004cited by this paper
• Piscirickettsia salmonis: a Gram-negative intracellular bacterial pathogen of fish.

  2003influential reference
• ASREML user guide release 1.0

  2002influential reference
• Genetics and Analysis of Quantitative Traits

  2001influential reference
• The sustainability, feasibility and desirability of breeding livestock for disease resistance.

  2001cited by this paper
• Genetic improvement of cold‐water fish species

  2000cited by this paper
• Routes of entry of Piscirickettsia salmonis in rainbow trout Oncorhynchus mykiss.

  1999influential reference
• Genetic correlations between survival of Atlantic salmon in challenge and field tests

  1997cited by this paper
• A Bayesian analysis of mixed survival models

  1996cited by this paper
• The isolation of a rickettsia‐like organism causing disease and mortality in Chilean salmonids and its confirmation by Koch's postulate

  1991cited by this paper
• Genetic origin of Norwegian farmed Atlantic salmon

  1991cited by this paper
• Genetic Variation in Resistance to Bacterial Kidney Disease within and between Two Strains of Coho Salmon from British Columbia

  1990cited by this paper
• Nonparametric Estimation from Incomplete Observations

  1958cited by this paper

• Genetic parameters for dermo challenge survival in a Virginia, U.S. eastern oyster breeding population

  2025cites this paper
• Survival, serum biochemical parameters, hepatic antioxidant status, and gene expression of three Nile tilapia strains under pathogenic Streptococcus agalactiae challenge.

  2024cites this paper
• Heritability of chronic thermal tolerance and genetic correlations with growth traits in the Pacific oyster (Crassostrea gigas)

  2023cites this paper
• Genetic and genomic analyses of resistance to yersiniosis in Atlantic salmon (Salmo salar) assessed by tank challenge

  2023cites this paper
• Heritability estimation of high salt tolerance in razor clam (Sinonovacula constricta)

  2022cites this paper
• Why Does Piscirickettsia salmonis Break the Immunological Paradigm in Farmed Salmon? Biological Context to Understand the Relative Control of Piscirickettsiosis

  2022cites this paper
• Genome-wide association study of VHSV-resistance trait in Paralichthys olivaceus.

  2022cites this paper
• GWAS meta-analysis of resistance against Piscirickettsia salmonis in Atlantic salmon

  2022cites this paper
• Genomic selection applications can improve the environmental performance of aquatics: A case study on the heat tolerance of abalone

  2022influential citation
• Resistance to Saprolegnia parasitica infection: A heritable trait in Atlantic salmon

  2022cites this paper
• Dissection of genotype × tissue interactions for immunological factors in turbot (Scophthalmus maximus) infected with Vibrio anguillarum.

  2021cites this paper
• The impact of Piscirickettsia Salmonis infection on genome-wide DNA methylation profile in Atlantic Salmon

  2021cites this paper
• Insights into the genetic covariation between harvest survival and growth rate in olive flounder (Paralichthys olivaceus) under commercial production environment

  2021cites this paper
• Genome-wide analysis of acute low salinity tolerance in the eastern oyster Crassostrea virginica and potential of genomic selection for trait improvement

  2021cites this paper
• Estimation of genetic parameters for resistance to Vibrio alginolyticus infection in the Pacific oyster (Crassostrea gigas)

  2021cites this paper
• Genome-Wide Association Analysis Reveals the Genetic Architecture of Parasite (Cryptocaryon irritans) Resistance in Large Yellow Croaker (Larimichthys crocea)

  2021cites this paper
• Genetics of growth and survival under chronic heat stress and trade-offs with growth- and robustness-related traits in rainbow trout

  2021cites this paper
• Genomic selection for parasitic ciliate Cryptocaryon irritans resistance in large yellow croaker

  2021cites this paper
• Selective breeding for juvenile survival in Chinese tongue sole (Cynoglossus semilaevis): Heritability and selection response

  2021cites this paper
• Heritability of disease resistance to Edwardsiella tarda in olive flounder (Paralichthys olivaceus)

  2020cites this paper
• Estimation of heritabilities of disease resistance to Edwardsiella tarda and genetic correlations between resistance and growth traits in Chinese tongue sole (Cynoglossus semilaevis)

  2020cites this paper
• Novel insights into the selective breeding for disease resistance to vibriosis by using natural outbreak survival data in Chinese tongue sole (Cynoglossus semilaevis)

  2020cites this paper
• Estimates of Autozygosity Through Runs of Homozygosity in Farmed Coho Salmon

  2020cites this paper
• Crossbreeding effects for White Spot Disease resistance in challenge tests and field pond performance in Pacific white shrimp Litopenaeus vannamei involving susceptible and resistance lines

  2020cites this paper
• Genetic Improvement of North American Atlantic Salmon and the Eastern Oyster Crassostrea virginica at the U.S. Department of Agriculture–Agricultural Research Service National Cold Water Marine Aquaculture Center

  2020cites this paper
• Quantitative genetic variation for resistance to the parasite Ichthyophthirius multifiliis in the Neotropical fish tambaqui (Colossoma macropomum)

  2020influential citation
• Genetic parameters for resistance to Tilapia Lake Virus (TiLV) in Nile tilapia (Oreochromis niloticus)

  2020cites this paper
• Investigating mechanisms underlying genetic resistance to Salmon Rickettsial Syndrome in Atlantic salmon using RNA sequencing

  2020cites this paper
• Genetic parameters for Piscirickettsia salmonis resistance, sea lice (Caligus rogercresseyi) susceptibility and harvest weight in rainbow trout (Oncorhynchus mykiss)

  2019cites this paper
• Genetic parameters for resistance against Vibrio anguillarum in turbot Scophthalmus maximus.

  2019cites this paper
• Genome-Wide Association Analysis for Resistance to Infectious Pancreatic Necrosis Virus Identifies Candidate Genes Involved in Viral Replication and Immune Response in Rainbow Trout (Oncorhynchus mykiss)

  2019cites this paper
• Genetic analysis of disease resistance to Vibrio harveyi by challenge test in Chinese tongue sole (Cynoglossus semilaevis)

  2019cites this paper
• Heritability estimates and selection response for resistance to Streptococcus agalactiae in red tilapia Oreochromis spp.

  2019cites this paper
• Single-Step Genome-Wide Association Study for Resistance to Piscirickettsia salmonis in Rainbow Trout (Oncorhynchus mykiss)

  2019cites this paper
• Comparative genomic analysis of three salmonid species identifies functional candidate genes involved in resistance to the intracellular bacteria Piscirickettsia salmonis

  2019cites this paper
• Eliciting expert judgements to estimate risk and protective factors for Piscirickettsiosis in Chilean salmon farming

  2019cites this paper
• Advances in genetic improvement for salmon and trout aquaculture: the Chilean situation and prospects

  2019cites this paper
• Novel insights into the genetic relationship between growth and disease resistance in an aquaculture strain of Coho salmon (Oncorhynchus kisutch)

  2019cites this paper
• Comparative Genomic Analysis of Three Salmonid Species Identifies Functional Candidate Genes Involved in Resistance to the Intracellular Bacterium Piscirickettsia salmonis

  2019cites this paper
• Selection response for Streptococcus agalactiae resistance in Nile tilapia Oreochromis niloticus.

  2019cites this paper
• Genetic parameters for resistance to Aeromonas hydrophila in the Neotropical fish pacu (Piaractus mesopotamicus)

  2019cites this paper
• Mapping quantitative trait loci for infectious salmon anaemia resistance in a North American strain of Atlantic salmon

  2019cites this paper
• Accuracy of genotype imputation and genomic predictions in a two-generation farmed Atlantic salmon population using high-density and low-density SNP panels

  2018cites this paper
• Estimation of genetic parameters for upper thermal tolerances and growth-related traits in turbot Scophthalmus maximus

  2018cites this paper
• Genomic Predictions and Genome-Wide Association Study of Resistance Against Piscirickettsia salmonis in Coho Salmon (Oncorhynchus kisutch) Using ddRAD Sequencing

  2018cites this paper
• Novel insights into the genetic relationship between growth and disease resistance in Pacific salmon

  2018cites this paper
• Genetic parameters for resistance against Flavobacterium columnare in Nile tilapia Oreochromis niloticus (Linnaeus, 1758).

  2018cites this paper
• Proceedings of the World Congress on Genetics Applied to Livestock Production, 11. 923 Using GBLUP selection for increased Piscirickettsia salmonis (SRS) resistance in Atlantic salmon (Salmo salar)

  2018cites this paper
• Population Genomic Structure and Genome-Wide Linkage Disequilibrium in Farmed Atlantic Salmon (Salmo salar L.) Using Dense SNP Genotypes

  2018cites this paper
• Genomic Prediction Accuracy for Resistance Against Piscirickettsia salmonis in Farmed Rainbow Trout

  2017cites this paper
• Vaccines for piscirickettsiosis (salmonid rickettsial septicaemia, SRS): the Chile perspective

  2017cites this paper
• Genome-wide association study and genomic predictions for resistance against Piscirickettsia salmonis in coho salmon (Oncorhynchus kisutch) using ddRAD sequencing

  2017influential citation
• Mate selection in aquaculture breeding using differential evolution algorithm.

  2017cites this paper
• Estimation of genetic parameters for resistance to Aeromonas hydrophila in blunt snout bream (Megalobrama amblycephala)

  2017cites this paper
• Additive genetic variation in resistance of Nile tilapia (Oreochromis niloticus) to Streptococcus iniae and S. agalactiae capsular type Ib: Is genetic resistance correlated?

  2017cites this paper
• Genetic variation in vibrio resistance in the clam Meretrix petechialis under the challenge of Vibrio parahaemolyticus

  2017cites this paper
• Bayesian genome-wide association analysis for body weight in farmed Atlantic salmon (Salmo salar L.).

  2017cites this paper
• Disease resistance in salmon IMPORTANCE OF DISEASE CONTROL IN SALMON FARMING

  2017cites this paper
• Genomic predictions can accelerate selection for resistance against Piscirickettsia salmonis in Atlantic salmon (Salmo salar)

  2017cites this paper
• Controlled challenge experiment demonstrates substantial additive genetic variation in resistance of Nile tilapia (Oreochromis niloticus) to Streptococcus iniae

  2016cites this paper
• Negative genetic correlation between resistance against Piscirickettsia salmonis and harvest weight in coho salmon (Oncorhynchus kisutch)

  2016influential citation
• Genomewide single nucleotide polymorphism discovery in Atlantic salmon (Salmo salar): validation in wild and farmed American and European populations

  2016cites this paper
• Ectoparasites and associated pathogens affecting farmed salmon during marine grow out in Chile and Australia

  2015cites this paper
• Effect of triploidy in the expression of immune-related genes in coho salmon Oncorhynchus kisutch (Walbaum) infected with Piscirickettsia salmonis

  2015cites this paper
• Rainbow trout (Oncorhynchus mykiss) resistance to columnaris disease is heritable and favorably correlated with bacterial cold water disease resistance.

  2015influential citation
• Transcriptional response of Atlantic salmon families to Piscirickettsia salmonis infection highlights the relevance of the iron-deprivation defence system

  2015cites this paper
• Potential Response to Selection of HSP70 as a Component of Innate Immunity in the Abalone Haliotis rufescens

  2015cites this paper
• Genome-wide association analysis reveals loci associated with resistance against Piscirickettsia salmonis in two Atlantic salmon (Salmo salar L.) chromosomes

  2015influential citation
• Genetic co-variation between resistance against both Caligus rogercresseyi and Piscirickettsia salmonis, and body weight in Atlantic salmon (Salmo salar)

  2014cites this paper
• Population genomic analyses of early-phase Atlantic Salmon (Salmo salar) domestication/captive breeding

  2014cites this paper
• Epidemiology of Piscirickettsiosis on selected Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss) salt water aquaculture farms in Chile

  2014cites this paper
• Disease Resistance in Atlantic Salmon (Salmo salar): Coinfection of the Intracellular Bacterial Pathogen Piscirickettsia salmonis and the Sea Louse Caligus rogercresseyi

  2014cites this paper
• Genetics and genomics of disease resistance in salmonid species

  2014cites this paper
• Estimates of

  year unknowncites this paper