A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2016-04-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1516604113PMID 27071083PMCID PMC4855616
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functions

  2018cited by this paper
• Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

  2017cited by this paper
• Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

  2015cited by this paper
• Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction.

  2015cited by this paper
• Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

  2015cited by this paper
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  2015cited by this paper
• The biology of proteostasis in aging and disease.

  2015cited by this paper
• Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases.

  2015cited by this paper
• REST and Stress Resistance in Aging and Alzheimer’s Disease

  2014cited by this paper
• A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease.

  2014cited by this paper
• The amyloid state and its association with protein misfolding diseases

  2014cited by this paper
• Heat of supersaturation-limited amyloid burst directly monitored by isothermal titration calorimetry

  2014cited by this paper
• Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration.

  2014cited by this paper
• The amyloid state and its association with protein misfolding diseases

  2014influential reference
• Gene Expression Profiles of Entorhinal Cortex in Alzheimer’s Disease

  2014cited by this paper
• Supersaturation-limited Amyloid Fibrillation of Insulin Revealed by Ultrasonication*

  2014cited by this paper
• A Conserved BDNF, Glutamate- and GABA-Enriched Gene Module Related to Human Depression Identified by Coexpression Meta-Analysis and DNA Variant Genome-Wide Association Studies

  2014cited by this paper
• Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.

  2013cited by this paper
• Genes and pathways underlying regional and cell type changes in Alzheimer's disease

  2013cited by this paper
• A preliminary study of the whole-genome expression profile of sporadic and monogenic early-onset Alzheimer's disease.

  2013cited by this paper
• Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins.

  2013influential reference
• Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study

  2013cited by this paper
• Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan

  2012cited by this paper
• Selection of novel reference genes for use in the human central nervous system: a BrainNet Europe Study

  2012cited by this paper
• Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

  2012cited by this paper
• Deciphering Alzheimer disease.

  2012cited by this paper
• Gene expression profiling in human neurodegenerative disease

  2012cited by this paper
• An Integrated Encyclopedia of DNA Elements in the Human Genome

  2012cited by this paper
• Protein homeostasis and aging: The importance of exquisite quality control.

  2011cited by this paper
• Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions.

  2011cited by this paper
• Alzheimer's disease.

  2011cited by this paper
• P3‐157: A novel microRNA interaction relevant to alzheimer's disease pathogenesis and drug target discovery: miR‐346 induces expression of amyloid precursor protein

  2011cited by this paper
• Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

  2010cited by this paper
• A dual function for chaperones SSB–RAC and the NAC nascent polypeptide–associated complex on ribosomes

  2010cited by this paper
• Alzheimer's disease.

  2010cited by this paper
• A negative regulator of MAP kinase causes depressive behavior.

  2010cited by this paper
• Mechanisms underlying inflammation in neurodegeneration.

  2010cited by this paper
• Mitochondrial ATP‐Synthase in the Entorhinal Cortex Is a Target of Oxidative Stress at Stages I/II of Alzheimer's Disease Pathology

  2010cited by this paper
• Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation

  2009cited by this paper
• Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease

  2009cited by this paper
• BIOPHYSICS AND COMPUTATIONAL BIOLOGY

  2009cited by this paper
• The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics

  2009cited by this paper
• Genetic control of human brain transcript expression in Alzheimer disease.

  2009cited by this paper
• Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

  2009cited by this paper
• Proteomic identification of novel proteins associated with Lewy bodies.

  2008cited by this paper
• Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

  2008cited by this paper
• Differential expression of oxidative phosphorylation genes in patients with Alzheimer’s disease

  2007cited by this paper
• Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.

  2007cited by this paper
• SERPINA3 (aka alpha-1-antichymotrypsin).

  2007cited by this paper
• Life on the edge: a link between gene expression levels and aggregation rates of human proteins.

  2007cited by this paper
• Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases

  2006cited by this paper
• Global aggregation of newly translated proteins in an Escherichia coli strain deficient of the chaperonin GroEL

  2006cited by this paper
• Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients.

  2006cited by this paper
• The roles of intracellular protein-degradation pathways in neurodegeneration

  2006cited by this paper
• Combining probability from independent tests: the weighted Z‐method is superior to Fisher's approach

  2005cited by this paper
• Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses

  2004cited by this paper
• Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders

  2004cited by this paper
• Proteomic Characterization of Postmortem Amyloid Plaques Isolated by Laser Capture Microdissection*[boxs]

  2004cited by this paper
• Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease.

  2003cited by this paper
• Association of atp synthase α-chain with neurofibrillary degeneration in alzheimer’s disease

  2003cited by this paper
• The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

  2002cited by this paper
• Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique.

  2001cited by this paper
• Expression profile of transcripts in Alzheimer's disease tangle‐bearing CA1 neurons

  2000cited by this paper
• Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease.

  1997cited by this paper
• Controlling the false discovery rate: a practical and powerful approach to multiple testing

  1995cited by this paper
• A Simple Sequentially Rejective Multiple Test Procedure

  1979cited by this paper
• Supersaturation in sickle cell hemoglobin solutions.

  1976cited by this paper
• The American soldier: Adjustment during army life. (Studies in social psychology in World War II), Vol. 1

  1949cited by this paper
• The American Soldier: Adjustment During Army Life.

  1949cited by this paper
• THE PROBABILITY INTEGRAL TRANSFORMATION FOR TESTING GOODNESS OF FIT AND COMBINING INDEPENDENT TESTS OF SIGNIFICANCE

  1938cited by this paper
• Statistical methods for research workers

  1927cited by this paper

• Examining the vulnerability of adult neuron subtypes to tau-mediated toxicity in Drosophila

  2025cites this paper
• The thermodynamic hypothesis of protein aggregation.

  2025cites this paper
• Molecular signatures of regional vulnerability to tauopathy in excitatory cortical neurons

  2025cites this paper
• Nuclear respiratory factor-1 (NRF1) induction drives mitochondrial biogenesis and attenuates amyloid beta-induced mitochondrial dysfunction and neurotoxicity

  2024cites this paper
• Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription

  2024cites this paper
• Monitoring and analysis of mitochondrial precursor protein aggregates in the cytosol.

  2024cites this paper
• Blood RNA transcripts show changes in inflammation and lipid metabolism in Alzheimer's disease and mitochondrial function in mild cognitive impairment

  2024cites this paper
• The ABC's of Alzheimer risk gene ABCA7

  2024cites this paper
• Mechanisms and pathology of protein misfolding and aggregation

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Integrative analysis of summary data from GWAS and eQTL studies implicates genes differentially expressed in Alzheimer’s disease

  2022cites this paper
• Vulnerability of the spinal motor neuron presynaptic terminal sub-proteome in ALS.

  2022cites this paper
• Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

  2022cites this paper
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  2022cites this paper
• Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice

  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Deep post-GWAS analysis identifies potential risk genes and risk variants for Alzheimer’s disease, providing new insights into its disease mechanisms

  2021cites this paper
• Cryptic amyloidogenic regions in intrinsically disordered proteins: Function and disease association

  2021cites this paper
• Interplay between mammalian heat shock factors 1 and 2 in physiology and pathology

  2021cites this paper
• Current Trends in Neurodegeneration: Cross Talks between Oxidative Stress, Cell Death, and Inflammation

  2021cites this paper
• Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

  2021cites this paper
• Mutations in the COPI coatomer subunit α-COP induce release of Aβ-42 and amyloid precursor protein intracellular domain and increase tau oligomerization and release.

  2021cites this paper
• Heterotypic interactions in amyloid function and disease

  2021cites this paper
• Exploring Common Therapeutic Targets for Neurodegenerative Disorders Using Transcriptome Study

  2021cites this paper
• CTRP9: An emerging potential anti-aging molecule in brain.

  2020cites this paper
• Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion.

  2020cites this paper
• Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration

  2020cites this paper
• Research Online Research Online The metastability of the proteome of spinal motor neurons underlies their The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS selective vulnerability in ALS

  2020cites this paper
• Transcriptomics in Alzheimer’s Disease: Aspects and Challenges

  2020cites this paper
• Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women With Alzheimer’s Disease

  2020cites this paper
• Locked in a vicious cycle: the connection between genomic instability and a loss of protein homeostasis

  2020cites this paper
• Telomeric alterations in the default mode network during the progression of Alzheimer’s disease: Selective vulnerability of the precuneus

  2020cites this paper
• Mitochondrial control of cellular protein homeostasis.

  2020cites this paper
• A Cell- and Tissue-Specific Weakness of the Protein Homeostasis System Underlies Brain Vulnerability to Protein Aggregation

  2020cites this paper
• rs4147929 variant minor allele increases ABCA7 gene expression and ABCA7 shows increased gene expression in Alzheimer’s disease patients compared with controls

  2020cites this paper
• Astrocyte regional diversity in ALS includes distinct aberrant phenotypes with common and causal pathological processes.

  2020cites this paper
• Melatonin and Melatonergic Influence on Neuronal Transcription Factors: Implications for the Development of Novel Therapies for Neurodegenerative Disorders

  2019cites this paper
• Exploring the selective vulnerability in Alzheimer disease using tissue specific variant analysis.

  2019cites this paper
• Network-based approach to identify molecular signatures and therapeutic agents in Alzheimer's disease

  2019cites this paper
• Brain aging: A Ianus‐faced player between health and neurodegeneration

  2019cites this paper
• Identification of exon skipping events associated with Alzheimer’s disease in the human hippocampus

  2019cites this paper
• The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS.

  2019cites this paper
• The Amyloid Phenomenon and Its Significance in Biology and Medicine.

  2019cites this paper
• Single-cell transcriptomic analysis of Alzheimer’s disease

  2019cites this paper
• Identification of Alzheimer's Disease Autoantibodies and Their Target Biomarkers by Phage Microarrays.

  2019cites this paper
• Cell Death and Neurodegeneration.

  2019cites this paper
• Genetic and Expression Analysis of COPI Genes and Alzheimer’s Disease Susceptibility

  2019cites this paper
• Escalating protein supersaturation underlies inclusion formation in muscle proteinopathies

  2019cites this paper
• Meta-Analysis of Gene Expression Changes in the Blood of Patients with Mild Cognitive Impairment and Alzheimer’s Disease Dementia

  2019cites this paper
• Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease

  2019cites this paper
• Benzoic acid derivative-modified chitosan-g-poly(N-isopropylacrylamide): Methoxylation effects and pharmacological treatments of Glaucoma-related neurodegeneration.

  2019cites this paper
• A metastable subproteome underlies inclusion formation in muscle proteinopathies

  2019cites this paper
• Failures in Protein Clearance Partly Underlie Late Onset Neurodegenerative Diseases and Link Pathology to Genetic Risk

  2019cites this paper
• A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

  2018cites this paper
• When pitch adds to volume: coregulation of transcript diversity predicts gene function

  2018cites this paper
• Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review

  2018cites this paper
• Selective vulnerability in neurodegenerative diseases

  2018cites this paper
• Identification of prefrontal cortex protein alterations in Alzheimer’s disease

  2018cites this paper
• SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS

  2018cites this paper
• Genetic variation within endolysosomal system is associated with late-onset Alzheimer’s disease

  2018cites this paper
• Kinetic Trapping of Folded Proteins Relative to Aggregates under Physiologically Relevant Conditions.

  2018cites this paper
• Proteomics studies of protein homeostasis and aggregation in ageing and neurodegeneration

  2018cites this paper
• HSF2 protects against proteotoxicity by maintaining cell-cell adhesion

  2018cites this paper
• Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics.

  2018cites this paper
• mPOS is a novel mitochondrial trigger of cell death – implications for neurodegeneration

  2018cites this paper
• Supersaturated proteins in ALS

  2017cites this paper
• Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

  2017cites this paper
• What have we learned on aging from omics studies?

  2017cites this paper
• Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade.

  2017cites this paper
• Three-way clustering of multi-tissue multi-individual gene expression data using constrained tensor decomposition

  2017cites this paper
• Homeostasis of metastable proteins in Alzheimer's disease

  2017influential citation
• Amyloid-like Fibrils from an α-Helical Transmembrane Protein

  2017cites this paper
• Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

  2017cites this paper
• Protein Folding Mediated by Trigger Factor and Hsp70: New Insights from Single-Molecule Approaches.

  2017cites this paper
• β-Amyloid and the Pathomechanisms of Alzheimer’s Disease: A Comprehensive View

  2017cites this paper
• Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology

  2017cites this paper
• SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS

  2017cites this paper
• Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system

  2017cites this paper
• Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS

  2017cites this paper
• A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease

  2016cites this paper